| Robox | Wii | 2010 | DreamBox Games |
| Rock 'n Ball | Nintendo Entertainment System | 1989 | KID |
| Rock 'n' Roll Adventures | Wii | 2007 | Data Design Interactive |
| Rock Band | Wii | 2007 | Pi Studios, Harmonix Music Systems |
| Rock Band 2 | Wii | 2008 | Harmonix Music Systems |
| Rock Band 3 | Wii | 2010 | Harmonix Music Systems, Backbone Emeryville |
| Rock Band Metal Track Pack | Wii | 2009 | Harmonix Music Systems |
| Rock Band: Country Track Pack | Wii | 2009 | Harmonix Music Systems |
| Rock Band: Country Track Pack 2 | Wii | 2011 | Harmonix Music Systems |
| Rock Band: Track Pack - Volume 1 | Wii | 2008 | Harmonix Music Systems |
| Rock Band: Track Pack - Volume 2 | Wii | 2008 | Harmonix Music Systems |
| Rock n' Roll Racing | Super Nintendo Entertainment System | 1993 | Blizzard Entertainment |
| Rock Revolution | Wii | 2008 | Zoë Mode |
| Rocket Power: Beach Bandits | Nintendo GameCube | 2002 | — |
| Rocket Ranger | Nintendo Entertainment System | 1988 | Cinemaware |
| Rockin' Kats | Nintendo Entertainment System | 1991 | Atlus |
| Rocko's Modern Life: Spunky's Dangerous Day | Super Nintendo Entertainment System | 1994 | Viacom |
| Rockstar Games presents Table Tennis | Wii | 2006 | Rockstar San Diego |
| Rocky | Nintendo GameCube | 2002 | Rage Games |
| Rocky Rodent | Super Nintendo Entertainment System | 1993 | Irem |
| Rod Land | Nintendo Entertainment System | 1990 | Jaleco |
| Rodea the Sky Soldier | Wii | 2015 | Prope |
| Roger Clemens' MVP Baseball | Nintendo Entertainment System, Super Nintendo Entertainment System | 1991 | Sculptured Software |
| Rogue Ops | Nintendo GameCube | 2003 | Bits Studios |
| Rogue Trooper | Wii | 2006 | Rebellion Developments |
| Rolan's Curse | Game Boy | 1990 | Sammy Corporation |
| Rolan's Curse II | Game Boy | 1992 | — |
| Rollerball | Nintendo Entertainment System | 1984 | HAL Laboratory |
| Rollerblade Racer | Nintendo Entertainment System | 1993 | Radiance Software |
| RollerCoaster Tycoon 3D | Nintendo 3DS | 2012 | n-Space |
| RollerGames | Nintendo Entertainment System | 1990 | Konami |
| Rolling Stone: Drum King | Wii | 2009 | 505 Games |
| Rolling Thunder | Nintendo Entertainment System | 1986 | Namco |
| Romance of the Three Kingdoms II | Nintendo Entertainment System, Super Nintendo Entertainment System | 1989 | Koei |
| Romance of the Three Kingdoms III: Dragon of Destiny | Super Nintendo Entertainment System | 1992 | Koei |
| Romance of the Three Kingdoms IV: Wall of Fire | Super Nintendo Entertainment System | 1994 | Koei |
| Romance of the Three Kingdoms XI | Wii | 2006 | Koei |
| Romancia | Nintendo Entertainment System | 1986 | Nihon Falcom |
| Romancing SaGa | Super Nintendo Entertainment System | 1992 | Square |
| Romancing SaGa 2 | Super Nintendo Entertainment System | 1993 | Square |
| Romancing SaGa 3 | Super Nintendo Entertainment System | 1995 | Square |
| Rooms: The Main Building | Wii | 2008 | Hudson Soft |
| Rotohex | Wii | 2008 | skip Ltd. |
| Rotozoa | Wii | 2010 | skip Ltd. |
| Roundball: 2 on 2 Challenge | Nintendo Entertainment System | 1992 | MindSpan, Park Place Productions |
| Route-16 | Nintendo Entertainment System | 1981 | Tecmo, Sunsoft |
| RPG Jinsei Game | Nintendo Entertainment System | 1993 | Tomy |
| RPG Maker Fes | Nintendo 3DS | 2016 | — |
| RPG Maker Fes Players | Nintendo 3DS | 2016 | — |
| RPG Tsukūru 2 | Super Nintendo Entertainment System | 1996 | Success |
| RPG Tsukūru: Super Dante | Super Nintendo Entertainment System | 1995 | Kuusoukagaku |
| RPM Racing | Super Nintendo Entertainment System | 1992 | Blizzard Entertainment |
| RTO | Nintendo 3DS | 2017 | nuGAME |
| RTO 2 | Nintendo 3DS | 2018 | nuGAME |
| Rubik's Cube | Nintendo 3DS | 2016 | Cypronia |
| Rubik's Puzzle World | Wii | 2008 | Two Tribes |
| Ruby & Rusty – Save the Crows | Game Boy | 2021 | — |
| Rudolph the Red-Nosed Reindeer | Wii | 2010 | High Voltage Software |
| Rugby League 3 | Wii | 2010 | Sidhe |
| Rugrats: Royal Ransom | Nintendo GameCube | 2002 | Avalanche Software |