| I Love Softball | Nintendo Entertainment System | 1989 | Marionette Co., Ltd. |
| I Spy Spooky Mansion | Wii | 1999 | Scholastic Corporation |
| I-Ninja | Nintendo GameCube | 2003 | Argonaut Games |
| I.F.O | Nintendo 3DS | 2017 | — |
| ICarly | Wii | 2009 | Blitz Games |
| ICarly 2: iJoin the Click! | Wii | 2010 | Big Blue Bubble |
| Ice Age 2: The Meltdown | Nintendo GameCube, Wii | 2006 | Eurocom |
| Ice Age: Continental Drift – Arctic Games | Nintendo 3DS, Wii | 2012 | Behaviour Interactive |
| Ice Age: Dawn of the Dinosaurs | Wii | 2009 | Eurocom |
| Ice Climber | Nintendo Entertainment System | 1985 | Nintendo Research & Development 1 |
| Ice Cream Surfer | PlayStation Vita, Nintendo 3DS | 2014 | Dolores Entertainment |
| Ice Hockey | Nintendo Entertainment System | 1988 | Nintendo Entertainment Analysis & Development, Nintendo Research & Development 2 |
| Ice Station Z | Nintendo 3DS | 2016 | Wobbly Tooth |
| Idea no Hi | Super Nintendo Entertainment System | 1994 | Office Koukan |
| Idol Hakkenden | Nintendo Entertainment System | 1989 | Winning Entertainment Group |
| Idol Janshi Suchie-Pai | Super Nintendo Entertainment System | 1993 | — |
| Igor: The Game | Wii | 2008 | Santa Cruz Games |
| Ihatovo Monogatari | Super Nintendo Entertainment System | 1993 | Hect |
| Ikari III: The Rescue | Nintendo Entertainment System | 1989 | SNK, SNK |
| Ikari Warriors | Nintendo Entertainment System | 1986 | SNK |
| Ikaruga | Nintendo GameCube | 2001 | Treasure |
| Ikenie no Yoru | Wii | 2011 | Marvelous Entertainment |
| Ikinari Musician | Nintendo Entertainment System | 1987 | Tokyo Shoseki |
| Ikki | Nintendo Entertainment System | 1985 | Tose Co. |
| Illuminated | Game Boy | 2023 | — |
| Illusion of Gaia | Super Nintendo Entertainment System | 1993 | Quintet |
| Illvelo | Wii | 2008 | Milestone |
| Imabikisō | Wii | 2007 | Chunsoft |
| Image Fight | Nintendo Entertainment System | 1990 | Irem |
| Imagine Babies 3D | Nintendo 3DS | 2012 | — |
| Imagine Babyz | Nintendo 3DS | 2007 | Ubisoft |
| Imagine Champion Rider 3D | Nintendo 3DS | 2013 | Neko Entertainment |
| Imagine Fashion Party | Wii | 2009 | Lexis Numérique |
| Imagine Fashion World 3D | Nintendo 3DS | 2012 | — |
| Imagine: Champion Rider | Wii | 2008 | Phoenix Studio |
| Imagine: Fashion Designer 3D | Nintendo 3DS | 2007 | — |
| Imperium | Super Nintendo Entertainment System | 1992 | Tokai Communications |
| Impossible Mission | Wii | 2007 | System 3 |
| Impossible Mission II | Nintendo Entertainment System | 1988 | Appaloosa Interactive |
| Inazuma Eleven | Nintendo 3DS | 2008 | Level-5 |
| Inazuma Eleven 1-2-3!! Endō Mamoru densetsu | Nintendo 3DS | 2012 | Level-5 |
| Inazuma Eleven 3 | Nintendo 3DS | 2010 | Level-5 |
| Inazuma Eleven GO | Nintendo 3DS | 2011 | Level-5 |
| Inazuma Eleven GO 2: Chrono Stone | Nintendo 3DS | 2012 | Level-5 |
| Inazuma Eleven GO 3: Galaxy | Nintendo 3DS | 2013 | Level-5 |
| Inazuma Eleven GO Strikers 2013 | Wii | 2012 | Level-5 |
| Inazuma Eleven Strikers | Wii | 2011 | Level-5 |
| Inazuma Eleven Strikers 2012 Xtreme | Wii | 2011 | Level-5 |
| Incantation | Super Nintendo Entertainment System | 1996 | Titus Interactive |
| Incoming! | Wii | 2009 | JV Games |
| Indiana Jones and the Last Crusade | Nintendo Entertainment System | 1991 | Taito |
| Indiana Jones and the Last Crusade: The Action Game | Nintendo Entertainment System | 1989 | Tiertex Design Studios |
| Indiana Jones and the Staff of Kings | Wii | 2009 | Behaviour Interactive |
| Indiana Jones and the Temple of Doom | Nintendo Entertainment System | 1988 | Atari Games |
| Indiana Jones' Greatest Adventures | Super Nintendo Entertainment System | 1994 | Lucasfilm Games, Factor 5 |
| Indianapolis 500 Legends | Wii | 2007 | Torus Games |
| Infiltrator | Nintendo Entertainment System, Apple II series | 1985 | Aackosoft, Gray Matter Inc. |
| Inindo: Way of the Ninja | Super Nintendo Entertainment System | 1991 | Koei |
| Initial D: Perfect Shift Online | Nintendo 3DS | 2014 | — |
| Inkub | Wii | 2010 | Cosmonaut Games |
| Inmost | Nintendo 3DS | 2020 | — |
| Insect Planet TD | Nintendo 3DS | 2018 | RandomSpin Games |
| Insector X | Nintendo Entertainment System | 1988 | Taito |
| Inspector Gadget | Super Nintendo Entertainment System | 1993 | Fortyfive |
| Intellivision Lives! | Nintendo GameCube | 1998 | Realtime Associates |
| International Cricket | Nintendo Entertainment System | 1992 | Krome Studios Melbourne |
| International Sensible Soccer | Super Nintendo Entertainment System | 1993 | — |
| International Superstar Soccer | Super Nintendo Entertainment System | 1994 | Konami |
| International Superstar Soccer | Game Boy | 1998 | — |
| International Superstar Soccer 2 | Nintendo GameCube | 2002 | Konami |
| International Superstar Soccer 3 | Nintendo GameCube | 2003 | Konami |
| International Superstar Soccer Deluxe | Super Nintendo Entertainment System | 1995 | Konami |
| International Tennis Tour | Super Nintendo Entertainment System | 1993 | — |
| Intervilles | Wii | 2007 | Belle Productions |
| Ippatsu Gyakuten: Keiba Keirin Kyōtei | Super Nintendo Entertainment System | 1996 | — |
| Iron Chef America: Supreme Cuisine | Wii | 2008 | Black Lantern Studios, Inc. |
| Iron Combat: War in the Air | Nintendo 3DS | 2013 | Amzy |
| Iron Commando | Super Nintendo Entertainment System | 1995 | Arcade Zone |
| Iron Man | Wii | 2008 | Sega Studios San Francisco |
| Iron Man 2 | Wii | 2010 | Sega Studios San Francisco |
| Iron Tank | Nintendo Entertainment System | 1988 | SNK, SNK |
| IronFall: Invasion | Nintendo 3DS | 2015 | — |
| Ironsword: Wizards & Warriors II | Nintendo Entertainment System | 1989 | Rare Ltd. |
| Island Days | Nintendo 3DS | 2014 | Overflow, Klon |
| Isolated Warrior | Nintendo Entertainment System | 1991 | KID |
| Isozuri: Ritou Hen | Super Nintendo Entertainment System | 1996 | — |
| Itadaki Street 2: Neon Sign wa Bara Iro ni | Super Nintendo Entertainment System | 1994 | ASCII Corporation |
| Itadaki Street: Watashi no Omise ni Yottette | Nintendo Entertainment System | 1991 | Game Studio |
| Itoi Shigesato no Bass Tsuri No. 1 | Super Nintendo Entertainment System | 1997 | HAL Laboratory |
| Ivan 'Ironman' Stewart's Super Off Road | Nintendo Entertainment System, Super Nintendo Entertainment System | 1989 | Leland Corporation |
| Ivy the Kiwi? | Wii | 2009 | Prope |