| Resident Evil 2 | Nintendo GameCube | 1998 | Tiger Electronics, Capcom, Factor 5, Rockstar San Diego |
| Resident Evil 3: Nemesis | Nintendo GameCube | 1999 | Capcom |
| Resident Evil 4 | Nintendo GameCube, Wii | 2005 | Capcom |
| Resident Evil 4: Wii Edition | Wii | 2007 | Capcom Production Studio 4 |
| Resident Evil Archives: Resident Evil | Wii | 2008 | Capcom |
| Resident Evil Zero | Nintendo GameCube, Wii | 2002 | Capcom |
| Resident Evil – Code: Veronica | Nintendo GameCube | 2000 | Capcom |
| Resident Evil: Code: Veronica X | Nintendo GameCube | — | Capcom |
| Resident Evil: Revelations | Nintendo 3DS | 2012 | Capcom, Tose Co. |
| Resident Evil: The Darkside Chronicles | Wii | 2009 | Capcom |
| Resident Evil: The Mercenaries 3D | Nintendo 3DS | 2011 | Capcom |
| Resident Evil: The Umbrella Chronicles | Wii | 2007 | Capcom |
| Retro City Rampage | PlayStation Vita, Wii | 2012 | Vblank Entertainment |
| Return to PopoloCrois: A Story of Seasons Fairytale | Nintendo 3DS | 2015 | — |
| Revelations: The Demon Slayer | Game Boy | 1992 | — |
| Revenge of the 'Gator | Game Boy | 1989 | HAL Laboratory |
| Revolution X | Super Nintendo Entertainment System | 1994 | Midway Games |
| Rex Ronan: Experimental Surgeon | Super Nintendo Entertainment System | 1994 | Sculptured Software |
| Rhythm Heaven Fever | Wii | 2011 | Nintendo Software Planning & Development |
| Rhythm Heaven Megamix | Nintendo 3DS | 2015 | Nintendo Software Planning & Development |
| Rhythm Thief & the Emperor’s Treasure | Nintendo 3DS | 2012 | Sega |
| Ribbit King | Nintendo GameCube | 2000 | Bandai |
| Riddick Bowe Boxing | Super Nintendo Entertainment System | 1994 | Malibu Comics |
| Ride! Equestrian Simulation | Wii | 2007 | Dancing Dots |
| Ridge Racer 3D | Nintendo 3DS | 2011 | Bandai Namco Entertainment |
| Rig Racer 2 | Wii | 2005 | Data Design Interactive |
| Ring King | Nintendo Entertainment System | 1987 | Namco |
| Ring ni Kakero | Super Nintendo Entertainment System | 1998 | — |
| Ringling Bros. and Barnum & Bailey Circus | Wii | 2009 | Cat Daddy Games |
| Ripple Island | Nintendo Entertainment System | 1988 | Sunsoft |
| Rise of the Guardians | Wii | 2012 | Torus Games |
| Rise of the Phoenix | Super Nintendo Entertainment System | 1993 | Koei |
| Rise of the Robots | Super Nintendo Entertainment System | 1994 | — |
| Rise: Race the Future | Nintendo 3DS | 2018 | — |
| Rival Turf! | Super Nintendo Entertainment System | 1992 | Jaleco |
| River City Ransom | Nintendo Entertainment System | 1989 | Technōs Japan |
| River City: Rival Showdown | Nintendo 3DS | 2016 | — |
| River City: Tokyo Rumble | Nintendo 3DS | 2013 | — |
| Road Fighter | Nintendo Entertainment System | 1984 | Konami |
| Road Rash | Game Boy | 1994 | Electronic Arts |
| Road Riot 4WD | Super Nintendo Entertainment System | 1991 | — |
| Road Runner's Death Valley Rally | Super Nintendo Entertainment System | 1992 | ICOM Simulations |
| Road Trip: The Arcade Edition | Nintendo GameCube | 2002 | Hudson Soft |
| RoadBlasters | Nintendo Entertainment System | 1987 | Atari Games |
| RoadKill | Nintendo GameCube | 2003 | Terminal Reality |
| Roadster | Game Boy | 1990 | Tose Co. |
| Robin Hood: Prince of Thieves | Nintendo Entertainment System, Game Boy | 1991 | Sculptured Software |
| Robocalypse: Beaver Defense | Wii | 2010 | Vogster Entertainment |
| Robocco Wars | Nintendo Entertainment System | 1991 | Taito |
| RoboCop | Nintendo Entertainment System, Game Boy | 1988 | Data East, Nichibutsu |
| RoboCop | Nintendo GameCube | 2003 | Titus Interactive |
| RoboCop 2 | Nintendo Entertainment System | 1990 | Painting by Numbers, Ltd. |
| RoboCop 3 | Nintendo Entertainment System | 1992 | Acclaim Studios London |
| RoboCop 3 | Super Nintendo Entertainment System | 1992 | Ocean Software |
| RoboCop Versus The Terminator | Super Nintendo Entertainment System | 1993 | Virgin Interactive |
| Robodemons | Nintendo Entertainment System | 1990 | Color Dreams |
| Robotech: Battlecry | Nintendo GameCube | 2002 | Vicious Cycle Software |
| Robotrek | Super Nintendo Entertainment System | 1994 | Quintet |
| Robots | Nintendo GameCube | 2005 | Eurocom |
| RoboWarrior | Nintendo Entertainment System | 1987 | Hudson Soft |