| Schlag den Raab | Wii | 2010 | Sproing Interactive Media |
| Schlag den Raab: Das 2. Spiel | Nintendo 3DS, Wii | 2011 | Sproing Interactive Media |
| Scooby-Doo Mystery | Super Nintendo Entertainment System | 1995 | Argonaut Games |
| Scooby-Doo Mystery | Super Nintendo Entertainment System | 1995 | Argonaut Games |
| Scooby-Doo! and the Spooky Swamp | Wii | 2010 | Torus Games |
| Scooby-Doo! First Frights | Wii | 2009 | Torus Games |
| Scooby-Doo! Mystery Mayhem | Nintendo GameCube | 2003 | Behaviour Interactive |
| Scooby-Doo! Night of 100 Frights | Nintendo GameCube | 2002 | Heavy Iron Studios |
| Scooby-Doo! Unmasked | Nintendo GameCube | 2005 | Behaviour Interactive |
| SCORE International Baja 1000 | Wii | 2008 | Left Field Productions |
| Scribblenauts Unlimited | Nintendo 3DS | 2012 | 5th Cell |
| SD Battle Oozumou: Heisei Hero Basho | Nintendo Entertainment System | 1990 | Banpresto |
| SD F-1 Grand Prix | Super Nintendo Entertainment System | 1995 | Video System |
| SD Gundam Gaiden 2: Entaku no Kishi | Super Nintendo Entertainment System | 1992 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari | Nintendo Entertainment System, Game Boy | 1990 | Tose Co. |
| SD Gundam Gaiden: Knight Gundam Monogatari - Ooinaru Isan | Super Nintendo Entertainment System | 1991 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari 2 - Hikari no Kishi | Nintendo Entertainment System | 1991 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari 3 - Densetsu no Kishi Dan | Nintendo Entertainment System, Game Boy | 1992 | Bandai |
| SD Gundam Gaiden: Lacroan Heroes | Game Boy | 1990 | Bandai |
| SD Gundam Gashapon Wars | Nintendo GameCube | 2005 | Bandai Visual |
| SD Gundam Generation: Axis Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Babylonia Kenkoku Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Colony Kaku Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Gryps Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Ichinen Sensouki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Zanscare Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam World: Gachapon Senshi - Scramble Wars | Wii | 1987 | Bandai |
| SD Gundam World: Gachapon Senshi - Scramble Wars - Map Collection | Nintendo Entertainment System | 1989 | Bandai |
| SD Gundam World: Gachapon Senshi 2 - Capsule Senki | Nintendo Entertainment System | 1989 | Opera House, Human Entertainment, Bandai |
| SD Gundam World: Gachapon Senshi 3 - Eiyuu Senki | Nintendo Entertainment System | 1990 | Opera House, Bandai |
| SD Gundam World: Gachapon Senshi 4 - New Type Story | Nintendo Entertainment System | 1991 | Tose Co., Bandai |
| SD Gundam World: Gachapon Senshi 5 - Battle of Universal Century | Nintendo Entertainment System | 1992 | Tose Co., Bandai |
| SD Gundam: G Generation Wars | Wii | 2009 | Bandai |
| SD Gundam: G Next | Super Nintendo Entertainment System | 1995 | Bandai |
| SD Gundam: G Next - Unit & map collection | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam: Gundam Wars | Nintendo Entertainment System | 1993 | Bandai |
| SD Gundam: GX | Super Nintendo Entertainment System | 1994 | Bandai |
| SD Gundam: Power Formation Puzzle | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam: Scad Hammers | Wii | 2006 | Bandai |
| SD Gundam: SD Sengokuden - Kunitori Monogatari | Game Boy | 1990 | Bandai |
| SD Gundam: SD Sengokuden 2 - Tenka Touitsu Hen | Game Boy | 1992 | Bandai |
| SD Gundam: SD Sengokuden 3 - Chijou Saikyou Hen | Game Boy | 1992 | Bandai |
| SD Hero Sōkessen: Taose Aku no Gundan | Nintendo Entertainment System | 1990 | Interlink Computer Sciences |
| SD Kidō Senshi Gundam 2 | Super Nintendo Entertainment System | 1993 | Bandai |
| SD Kidō Senshi Gundam: V Sakusen Shidō | Super Nintendo Entertainment System | 1992 | Bandai |
| SD Mobile Suit Gundam | Super Nintendo Entertainment System | 1992 | — |
| SD Rupan Sansei - Kinko yaburi daisakusen | Game Boy | 1990 | — |
| Sea Monsters: A Prehistoric Adventure | Wii | 2007 | Atomic Planet Entertainment |
| SeaQuest DSV | Super Nintendo Entertainment System | 1994 | Sculptured Software |
| Second Sight | Nintendo GameCube | 2004 | Crytek UK |
| Secret Files 2: Puritas Cordis | Wii | 2009 | Animation Arts |
| Secret Files: Tunguska | Wii | 2006 | Animation Arts |
| Secret Mysteries in Amsterdam | Nintendo 3DS | 2012 | Engine Software |
| Secret Mysteries in New York | Nintendo 3DS | 2012 | — |
| Secret of Evermore | Super Nintendo Entertainment System | 1995 | Square |
| Secret of Mana | Super Nintendo Entertainment System, Wii | 1993 | Square |
| Secret of the Stars | Super Nintendo Entertainment System | 1993 | Tecmo |
| Secret Scout in the Temple of Demise | Nintendo Entertainment System | — | Color Dreams |
| Section Z | Nintendo Entertainment System | 1985 | Capcom |
| Sega 3D Classics Collection | Nintendo 3DS | 2014 | M2 |