| Ruin Arm | Super Nintendo Entertainment System | 1995 | Tose Co. |
| Run Saber | Super Nintendo Entertainment System | 1993 | GameFAQs |
| Runaway 2: The Dream of the Turtle | Wii | 2006 | Pendulo Studios, S.L. |
| Runbow | Nintendo 3DS | 2015 | — |
| Rune Factory 4 | Nintendo 3DS | 2012 | Neverland |
| Rune Factory Frontier | Wii | 2008 | Neverland |
| Rune Factory: Tides of Destiny | Wii | 2011 | Neverland |
| Rush'n Attack | Nintendo Entertainment System | 1985 | Konami |
| Rusty's Real Deal Baseball | Nintendo 3DS | 2013 | Nintendo |
| Rygar | Nintendo Entertainment System | 1987 | Tecmo |
| Rygar: The Legendary Adventure | Wii | 2002 | Tecmo |
| S.C.A.T.: Special Cybernetic Attack Team | Nintendo Entertainment System | 1990 | Winning Entertainment Group |
| Sadness | Wii | — | Nibris |
| Safecracker: The Ultimate Puzzle Adventure | Wii | 2006 | Kheops Studio |
| Sailor Moon | Super Nintendo Entertainment System | 1993 | Bandai |
| Sailor Moon R | Super Nintendo Entertainment System | 1993 | — |
| Sailor Moon S: Jōgai rantō!? Shuyaku sōdatsusen | Super Nintendo Entertainment System | 1994 | Arc System Works |
| Saint Paradise | Game Boy | 1992 | — |
| Saint Seiya : Ougon Densetsu | Nintendo Entertainment System | 1987 | Tose Co. |
| Saint Seiya: Ougon Densetsu Kanketsu Hen | Nintendo Entertainment System | 1988 | Tose Co. |
| Saints Row: Money Shot | Nintendo 3DS | — | THQ |
| Saiyūki World | Nintendo Entertainment System | 1988 | NMK |
| Sakura Wars: So Long, My Love | Wii | 2005 | Sega, Idea Factory, Red Entertainment |
| Salamander | Nintendo Entertainment System | 1986 | Konami |
| Sam & Max Beyond Time and Space | Wii | 2007 | Telltale Games |
| Sam & Max Save the World | Wii | 2006 | Telltale Games |
| Sam & Max: Ice Station Santa | Wii | 2007 | Telltale Games |
| Samba de Amigo | Wii | 2000 | Sonic Team |
| SameGame | Wii | 1985 | Hudson Soft |
| Samurai Defender | Nintendo 3DS | 2013 | — |
| Samurai G | Nintendo 3DS | 2012 | UFO Interactive Games |
| Samurai Jack: The Shadow of Aku | Nintendo GameCube | 2004 | Amaze Entertainment |
| Samurai Shodown | Super Nintendo Entertainment System, Game Boy | 1993 | SNK |
| Samurai Shodown Anthology | Wii | 2008 | SNK |
| Samurai Shodown VI | Wii | 2005 | SNK |
| Samurai Warriors 3 | Wii | 2009 | Koei Tecmo Holdings |
| Samurai Warriors Chronicles 3 | PlayStation Vita, Nintendo 3DS | 2014 | — |
| Samurai Warriors: Chronicles | Nintendo 3DS | 2011 | Koei Tecmo Holdings |
| Samurai Warriors: Katana | Wii | 2007 | Koei Tecmo Holdings |
| San Francisco Rush 2049 | Nintendo GameCube | 1999 | Atari Games, Handheld Games |
| San Francisco Rush: Extreme Racing | Nintendo GameCube | 1997 | Atari Games, Midway Games, Climax Studios |
| Sandy Beach | Wii | 2009 | Frozen Codebase |
| Sangokushi | Nintendo Entertainment System | 1988 | Tose Co. |
| Sangokushi Eiketsuden | Super Nintendo Entertainment System | 1995 | — |
| Sanma no Meitantei | Nintendo Entertainment System | 1987 | Namco |
| Sanrio Characters Picross | Nintendo 3DS | 2018 | Jupiter |
| Sanrio Cup: Pon Pon Volley | Nintendo Entertainment System | 1992 | Character Soft |
| Sanrio World Smash Ball! | Super Nintendo Entertainment System | 1993 | — |
| Sansara Naga | Super Nintendo Entertainment System | 1990 | — |
| Sansara Naga 2 | Super Nintendo Entertainment System | 1994 | — |
| Sansū 2-nen: Keisan Game | Nintendo Entertainment System | 1986 | Tokyo Shoseki |
| Sasa | Nintendo Entertainment System | 1985 | MTL |
| Satoru Nakajima F-1 Hero 2 | Nintendo Entertainment System | 1991 | Human Entertainment |
| Satoru Nakajima F-1 Hero GB World Championship '91 | Game Boy | 1991 | — |
| Saturday Night Slam Masters | Super Nintendo Entertainment System | 1993 | Capcom |
| Sayonara Umihara Kawase | Nintendo 3DS | 2013 | Studio Saizensen |
| Scaler | Nintendo GameCube | 2004 | Behaviour Interactive |
| Scarface: The World Is Yours | Wii | 2006 | Radical Entertainment |
| Scene It? Bright Lights! Big Screen! | Wii | 2009 | Behaviour Interactive |
| Scene It? Twilight | Wii | 2009 | Paramount Digital Entertainment |