| R-Type III: The Third Lightning | Super Nintendo Entertainment System, Wii | 1993 | Irem |
| R.B.I. Baseball | Nintendo Entertainment System | 1986 | Namco |
| R.B.I. Baseball 2 | Nintendo Entertainment System | 1987 | — |
| R.B.I. Baseball 3 | Super Nintendo Entertainment System | 1991 | — |
| R.C. Pro-Am | Nintendo Entertainment System | 1988 | Rare Ltd. |
| R.C. Pro-Am II | Nintendo Entertainment System | 1992 | Rare Ltd. |
| R: Racing Evolution | Nintendo GameCube | 2003 | Namco |
| Rabbids Go Home | Wii | 2009 | Ubisoft Montpellier |
| Rabbids Rumble | Nintendo 3DS | 2012 | Kuju Ltd. |
| Race America | Nintendo Entertainment System | 1990 | Imagineering |
| Race Days | Game Boy | 1994 | Gremlin Interactive |
| Race Drivin' | Super Nintendo Entertainment System | 1990 | Atari Games |
| Racer Mini Yonku: Japan Cup | Nintendo Entertainment System | 1989 | Konami |
| Racing Damashii | Game Boy | 1991 | Irem |
| Racing Simulation 3 | Nintendo GameCube | 2002 | Ubisoft |
| Racket Attack | Nintendo Entertainment System | 1988 | Tose Co. |
| Racket Sports Party | Wii | 2010 | Asobo Studio |
| Rackets & Rivals | Nintendo Entertainment System | 1993 | Konami |
| Racquet Sports | Wii | 2010 | Nir |
| Rad Racer | Nintendo Entertainment System | 1987 | Square |
| Radia Senki: Reimeihen | Nintendo Entertainment System | 1991 | Tecmo |
| Radiant Historia: Perfect Chronology | Nintendo 3DS | 2017 | — |
| Radical Dreamers | Super Nintendo Entertainment System | 1996 | Square |
| Radical Rex | Super Nintendo Entertainment System | 1994 | Krome Studios Melbourne, Piko Interactive |
| Radiohammer | PlayStation Vita, Nintendo 3DS | 2014 | — |
| Radirgy | Nintendo GameCube | 2005 | Milestone |
| Radirgy Noa | Wii | 2010 | Milestone |
| Rage of the Gladiator | Nintendo 3DS, Wii | 2010 | Ghostfire Games |
| Raging Fighter | Game Boy | 1993 | Konami |
| Raid 2020 | Nintendo Entertainment System | 1989 | Color Dreams |
| Raid on Bungeling Bay | Nintendo Entertainment System | 1984 | Aackosoft, Will Wright |
| Raiden | Super Nintendo Entertainment System | 1991 | Seibu Kaihatsu |
| Rainbow Islands: The Story of Bubble Bobble 2 | Nintendo Entertainment System | 1987 | Taito |
| Rainbow Islands: Towering Adventure! | Wii | 2009 | Taito |
| Rainbow Snake | Nintendo 3DS | 2017 | — |
| Raishi | PlayStation Vita, Nintendo 3DS | 2015 | — |
| Rally Bike | Nintendo Entertainment System | 1988 | Toaplan |
| Rally Championship | Nintendo GameCube | 2002 | Warthog Games |
| Rambo | Nintendo Entertainment System | 1987 | Pack-In-Video |
| Rampage | Nintendo Entertainment System, Wii | 1986 | Midway Games |
| Rampage: Total Destruction | Nintendo GameCube, Wii | 2006 | Pipeworks Software |
| Rampart | Nintendo Entertainment System, Super Nintendo Entertainment System | 1990 | Atari Games |
| Rango | Wii | 2011 | Behaviour Interactive |
| Ranma ½ | Game Boy | 1990 | Banpresto |
| Ranma ½: Chougi Ranbu Hen | Super Nintendo Entertainment System | 1994 | — |
| Ranma ½: Chōnai Gekitōhen | Super Nintendo Entertainment System | 1992 | Nippon Computer Systems |
| Ranma ½: Hard Battle | Super Nintendo Entertainment System | 1992 | Nippon Computer Systems |
| Ranma ½: Hidden Treasures of the Crimson Cats | Super Nintendo Entertainment System | 1993 | — |
| Rapala Fishing Frenzy 2009 | Wii | 2008 | Modus Studios Bucharest |
| Rapala Pro Bass Fishing | Wii | 2010 | Modus Studios Bucharest |
| Rapala Tournament Fishing | Wii | 2006 | Modus Studios Bucharest |
| Rapala: We Fish | Wii | 2009 | Polygon Magic |
| Rasāru Ishii no Childs Quest | Nintendo Entertainment System | 1989 | Namco |
| Ratatouille | Nintendo GameCube, Wii | 2007 | Asobo Studio |
| Ratatouille | Wii | 2007 | Asobo Studio |
| Ratatouille | Nintendo GameCube, Wii | 2007 | Heavy Iron Studios |
| Rats! | Game Boy | 1998 | — |
| Rave Master | Nintendo GameCube | 2002 | Konami |
| Raving Rabbids: Travel in Time | Wii | 2010 | Ubisoft Paris |
| Rayman | Nintendo 3DS | 1995 | Ubisoft Montpellier |
| Rayman 3: Hoodlum Havoc | Nintendo GameCube | 2003 | Ubisoft, Ubisoft Shanghai |
| Rayman M | Nintendo GameCube | 2001 | Ubisoft Montpellier |
| Rayman Origins | PlayStation Vita, Nintendo 3DS, Wii | 2011 | Ubisoft Montpellier |
| Rayman Raving Rabbids | Wii | 2006 | Ubisoft Montpellier |
| Rayman Raving Rabbids 2 | Nintendo 3DS, Wii | 2007 | Ubisoft |
| Rayman Raving Rabbids: TV Party | Wii | 2008 | Ubisoft Paris |
| Reader Rabbit Kindergarten: Bounce Down in Balloon Town! | Wii | 2001 | Graffiti Entertainment, The Learning Company |
| Reader Rabbit Preschool: Sparkle Star Rescue | Wii | 2001 | The Learning Company |
| Ready 2 Rumble: Revolution | Wii | 2009 | Syn Sophia |
| Ready Set Word | Wii | — | Ubisoft |
| Real Heroes: Firefighter | Wii | 2009 | Epicenter Studios |
| Realm | Super Nintendo Entertainment System | 1997 | Titus Interactive |
| Rebel Raiders: Operation Nighthawk | Wii | 2006 | Kando Games |
| Rec Room Games | Wii | 2009 | Arcade Moon |
| Recca | Nintendo Entertainment System | 1992 | KID |
| Record of Lodoss War | Super Nintendo Entertainment System | 1995 | — |
| Recruit Simulation: Shuushoku Game | Super Nintendo Entertainment System | 1995 | — |
| Red Faction II | Nintendo GameCube | 2002 | Volition |
| Red Steel | Wii | 2006 | Ubisoft Paris |
| Red Steel 2 | Wii | 2010 | Ubisoft |
| RedCard 2003 | Nintendo GameCube | 2002 | Point of View, Inc. |
| Reel Fishing Challenge | Wii | 2009 | Marvelous Entertainment |
| Reel Fishing Paradise 3D | Nintendo 3DS | 2011 | Winning Entertainment Group |
| Reel Fishing: Angler's Dream | Wii | 2009 | Marvelous Entertainment |
| Regular Show: Mordecai and Rigby in 8-Bit Land | Nintendo 3DS | 2013 | WayForward Technologies |
| Rei Fighter Gekitsui Senki | Nintendo GameCube | 2003 | Global A Entertainment |
| Reign of Fire | Nintendo GameCube | 2002 | Kuju Ltd. |
| Rejoice: Aretha Ōkoku no Kanata | Super Nintendo Entertainment System | 1995 | Japan Art Media |
| Relief Pitcher | Super Nintendo Entertainment System | 1992 | — |
| Reload | Wii | 2010 | Mastiff LLC |
| Remington Super Slam Hunting: Alaska | Wii | 2011 | eV Interactive |
| Remington Super Slam Hunting: North America | Wii | 2010 | Jack of All Games |
| Remington: Great American Bird Hunt | Wii | 2009 | Kouyousha |
| Remote Control | Nintendo Entertainment System | 1990 | RSP, Inc. |
| Rendering Ranger: R2 | Super Nintendo Entertainment System | 1995 | Rainbow Arts |
| Renegade | Nintendo Entertainment System | 1986 | Technōs Japan |
| Resident Evil | Nintendo GameCube, Wii | 2002 | Capcom |
| Resident Evil 2 | Nintendo GameCube | 1998 | Tiger Electronics, Capcom, Factor 5, Rockstar San Diego |
| Resident Evil 3: Nemesis | Nintendo GameCube | 1999 | Capcom |
| Resident Evil 4 | Nintendo GameCube, Wii | 2005 | Capcom |
| Resident Evil 4: Wii Edition | Wii | 2007 | Capcom Production Studio 4 |
| Resident Evil Archives: Resident Evil | Wii | 2008 | Capcom |
| Resident Evil Zero | Nintendo GameCube, Wii | 2002 | Capcom |
| Resident Evil – Code: Veronica | Nintendo GameCube | 2000 | Capcom |
| Resident Evil: Code: Veronica X | Nintendo GameCube | — | Capcom |
| Resident Evil: Revelations | Nintendo 3DS | 2012 | Capcom, Tose Co. |
| Resident Evil: The Darkside Chronicles | Wii | 2009 | Capcom |
| Resident Evil: The Mercenaries 3D | Nintendo 3DS | 2011 | Capcom |
| Resident Evil: The Umbrella Chronicles | Wii | 2007 | Capcom |
| Retro City Rampage | PlayStation Vita, Wii | 2012 | Vblank Entertainment |
| Return to PopoloCrois: A Story of Seasons Fairytale | Nintendo 3DS | 2015 | — |
| Revelations: The Demon Slayer | Game Boy | 1992 | — |
| Revenge of the 'Gator | Game Boy | 1989 | HAL Laboratory |
| Revolution X | Super Nintendo Entertainment System | 1994 | Midway Games |
| Rex Ronan: Experimental Surgeon | Super Nintendo Entertainment System | 1994 | Sculptured Software |
| Rhythm Heaven Fever | Wii | 2011 | Nintendo Software Planning & Development |
| Rhythm Heaven Megamix | Nintendo 3DS | 2015 | Nintendo Software Planning & Development |
| Rhythm Thief & the Emperor’s Treasure | Nintendo 3DS | 2012 | Sega |
| Ribbit King | Nintendo GameCube | 2000 | Bandai |
| Riddick Bowe Boxing | Super Nintendo Entertainment System | 1994 | Malibu Comics |
| Ride! Equestrian Simulation | Wii | 2007 | Dancing Dots |
| Ridge Racer 3D | Nintendo 3DS | 2011 | Bandai Namco Entertainment |
| Rig Racer 2 | Wii | 2005 | Data Design Interactive |
| Ring King | Nintendo Entertainment System | 1987 | Namco |
| Ring ni Kakero | Super Nintendo Entertainment System | 1998 | — |
| Ringling Bros. and Barnum & Bailey Circus | Wii | 2009 | Cat Daddy Games |
| Ripple Island | Nintendo Entertainment System | 1988 | Sunsoft |
| Rise of the Guardians | Wii | 2012 | Torus Games |
| Rise of the Phoenix | Super Nintendo Entertainment System | 1993 | Koei |
| Rise of the Robots | Super Nintendo Entertainment System | 1994 | — |
| Rise: Race the Future | Nintendo 3DS | 2018 | — |
| Rival Turf! | Super Nintendo Entertainment System | 1992 | Jaleco |
| River City Ransom | Nintendo Entertainment System | 1989 | Technōs Japan |
| River City: Rival Showdown | Nintendo 3DS | 2016 | — |
| River City: Tokyo Rumble | Nintendo 3DS | 2013 | — |
| Road Fighter | Nintendo Entertainment System | 1984 | Konami |
| Road Rash | Game Boy | 1994 | Electronic Arts |
| Road Riot 4WD | Super Nintendo Entertainment System | 1991 | — |
| Road Runner's Death Valley Rally | Super Nintendo Entertainment System | 1992 | ICOM Simulations |
| Road Trip: The Arcade Edition | Nintendo GameCube | 2002 | Hudson Soft |
| RoadBlasters | Nintendo Entertainment System | 1987 | Atari Games |
| RoadKill | Nintendo GameCube | 2003 | Terminal Reality |
| Roadster | Game Boy | 1990 | Tose Co. |
| Robin Hood: Prince of Thieves | Nintendo Entertainment System, Game Boy | 1991 | Sculptured Software |
| Robocalypse: Beaver Defense | Wii | 2010 | Vogster Entertainment |
| Robocco Wars | Nintendo Entertainment System | 1991 | Taito |
| RoboCop | Nintendo Entertainment System, Game Boy | 1988 | Data East, Nichibutsu |
| RoboCop | Nintendo GameCube | 2003 | Titus Interactive |
| RoboCop 2 | Nintendo Entertainment System | 1990 | Painting by Numbers, Ltd. |
| RoboCop 3 | Nintendo Entertainment System | 1992 | Acclaim Studios London |
| RoboCop 3 | Super Nintendo Entertainment System | 1992 | Ocean Software |
| RoboCop Versus The Terminator | Super Nintendo Entertainment System | 1993 | Virgin Interactive |
| Robodemons | Nintendo Entertainment System | 1990 | Color Dreams |
| Robotech: Battlecry | Nintendo GameCube | 2002 | Vicious Cycle Software |
| Robotrek | Super Nintendo Entertainment System | 1994 | Quintet |
| Robots | Nintendo GameCube | 2005 | Eurocom |
| RoboWarrior | Nintendo Entertainment System | 1987 | Hudson Soft |
| Robox | Wii | 2010 | DreamBox Games |
| Rock 'n Ball | Nintendo Entertainment System | 1989 | KID |
| Rock 'n' Roll Adventures | Wii | 2007 | Data Design Interactive |
| Rock Band | Wii | 2007 | Pi Studios, Harmonix Music Systems |
| Rock Band 2 | Wii | 2008 | Harmonix Music Systems |
| Rock Band 3 | Wii | 2010 | Harmonix Music Systems, Backbone Emeryville |
| Rock Band Metal Track Pack | Wii | 2009 | Harmonix Music Systems |
| Rock Band: Country Track Pack | Wii | 2009 | Harmonix Music Systems |
| Rock Band: Country Track Pack 2 | Wii | 2011 | Harmonix Music Systems |
| Rock Band: Track Pack - Volume 1 | Wii | 2008 | Harmonix Music Systems |
| Rock Band: Track Pack - Volume 2 | Wii | 2008 | Harmonix Music Systems |
| Rock n' Roll Racing | Super Nintendo Entertainment System | 1993 | Blizzard Entertainment |
| Rock Revolution | Wii | 2008 | Zoë Mode |
| Rocket Power: Beach Bandits | Nintendo GameCube | 2002 | — |
| Rocket Ranger | Nintendo Entertainment System | 1988 | Cinemaware |
| Rockin' Kats | Nintendo Entertainment System | 1991 | Atlus |
| Rocko's Modern Life: Spunky's Dangerous Day | Super Nintendo Entertainment System | 1994 | Viacom |
| Rockstar Games presents Table Tennis | Wii | 2006 | Rockstar San Diego |
| Rocky | Nintendo GameCube | 2002 | Rage Games |
| Rocky Rodent | Super Nintendo Entertainment System | 1993 | Irem |
| Rod Land | Nintendo Entertainment System | 1990 | Jaleco |
| Rodea the Sky Soldier | Wii | 2015 | Prope |
| Roger Clemens' MVP Baseball | Nintendo Entertainment System, Super Nintendo Entertainment System | 1991 | Sculptured Software |
| Rogue Ops | Nintendo GameCube | 2003 | Bits Studios |
| Rogue Trooper | Wii | 2006 | Rebellion Developments |
| Rolan's Curse | Game Boy | 1990 | Sammy Corporation |
| Rolan's Curse II | Game Boy | 1992 | — |
| Rollerball | Nintendo Entertainment System | 1984 | HAL Laboratory |
| Rollerblade Racer | Nintendo Entertainment System | 1993 | Radiance Software |
| RollerCoaster Tycoon 3D | Nintendo 3DS | 2012 | n-Space |
| RollerGames | Nintendo Entertainment System | 1990 | Konami |
| Rolling Stone: Drum King | Wii | 2009 | 505 Games |
| Rolling Thunder | Nintendo Entertainment System | 1986 | Namco |
| Romance of the Three Kingdoms II | Nintendo Entertainment System, Super Nintendo Entertainment System | 1989 | Koei |
| Romance of the Three Kingdoms III: Dragon of Destiny | Super Nintendo Entertainment System | 1992 | Koei |
| Romance of the Three Kingdoms IV: Wall of Fire | Super Nintendo Entertainment System | 1994 | Koei |
| Romance of the Three Kingdoms XI | Wii | 2006 | Koei |
| Romancia | Nintendo Entertainment System | 1986 | Nihon Falcom |
| Romancing SaGa | Super Nintendo Entertainment System | 1992 | Square |
| Romancing SaGa 2 | Super Nintendo Entertainment System | 1993 | Square |
| Romancing SaGa 3 | Super Nintendo Entertainment System | 1995 | Square |
| Rooms: The Main Building | Wii | 2008 | Hudson Soft |
| Rotohex | Wii | 2008 | skip Ltd. |
| Rotozoa | Wii | 2010 | skip Ltd. |
| Roundball: 2 on 2 Challenge | Nintendo Entertainment System | 1992 | MindSpan, Park Place Productions |
| Route-16 | Nintendo Entertainment System | 1981 | Tecmo, Sunsoft |
| RPG Jinsei Game | Nintendo Entertainment System | 1993 | Tomy |
| RPG Maker Fes | Nintendo 3DS | 2016 | — |
| RPG Maker Fes Players | Nintendo 3DS | 2016 | — |
| RPG Tsukūru 2 | Super Nintendo Entertainment System | 1996 | Success |
| RPG Tsukūru: Super Dante | Super Nintendo Entertainment System | 1995 | Kuusoukagaku |
| RPM Racing | Super Nintendo Entertainment System | 1992 | Blizzard Entertainment |
| RTO | Nintendo 3DS | 2017 | nuGAME |
| RTO 2 | Nintendo 3DS | 2018 | nuGAME |
| Rubik's Cube | Nintendo 3DS | 2016 | Cypronia |
| Rubik's Puzzle World | Wii | 2008 | Two Tribes |
| Ruby & Rusty – Save the Crows | Game Boy | 2021 | — |
| Rudolph the Red-Nosed Reindeer | Wii | 2010 | High Voltage Software |
| Rugby League 3 | Wii | 2010 | Sidhe |
| Rugrats: Royal Ransom | Nintendo GameCube | 2002 | Avalanche Software |
| Ruin Arm | Super Nintendo Entertainment System | 1995 | Tose Co. |
| Run Saber | Super Nintendo Entertainment System | 1993 | GameFAQs |
| Runaway 2: The Dream of the Turtle | Wii | 2006 | Pendulo Studios, S.L. |
| Runbow | Nintendo 3DS | 2015 | — |
| Rune Factory 4 | Nintendo 3DS | 2012 | Neverland |
| Rune Factory Frontier | Wii | 2008 | Neverland |
| Rune Factory: Tides of Destiny | Wii | 2011 | Neverland |
| Rush'n Attack | Nintendo Entertainment System | 1985 | Konami |
| Rusty's Real Deal Baseball | Nintendo 3DS | 2013 | Nintendo |
| Rygar | Nintendo Entertainment System | 1987 | Tecmo |
| Rygar: The Legendary Adventure | Wii | 2002 | Tecmo |