| X | Game Boy | 1992 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| X-Kaliber 2097 | Super Nintendo Entertainment System | 1994 | — |
| X-Men Legends | Nintendo GameCube | 2004 | Raven Software, Barking Lizards Technologies |
| X-Men Legends II: Rise of Apocalypse | Nintendo GameCube | 2005 | Raven Software |
| X-Men Origins: Wolverine | Wii | 2009 | Raven Software |
| X-Men: Destiny | Wii | 2011 | Silicon Knights |
| X-Men: Mutant Apocalypse | Super Nintendo Entertainment System | 1994 | Capcom |
| X-Men: Next Dimension | Nintendo GameCube | 2002 | Midway Studios – Los Angeles |
| X-Men: The Official Game | Nintendo GameCube | 2006 | Underground Development |
| X-Zone | Super Nintendo Entertainment System | 1992 | Kemco |
| X2: Wolverine's Revenge | Nintendo GameCube | 2003 | — |
| Xak: The Art of Visual Stage | Super Nintendo Entertainment System | 1992 | Microcabin |
| Xandra no Daibōken: Valkyrie to no Deai | Super Nintendo Entertainment System | 1992 | — |
| Xardion | Super Nintendo Entertainment System | 1992 | Jorudan |
| Xeno Crisis | Nintendo GameCube | 2019 | Bitmap Bureau |
| Xenoblade Chronicles | Wii | 2010 | Monolith Soft Inc. |
| Xenoblade Chronicles 3D | Nintendo 3DS | 2015 | — |
| Xenophobe | Nintendo Entertainment System | 1987 | Midway Games, Sunsoft |
| Xevious | Nintendo Entertainment System | 1982 | Namco |
| Xexyz | Nintendo Entertainment System | 1988 | Hudson Soft |
| XGRA: Extreme G Racing Association | Nintendo GameCube | 2003 | Acclaim Studios London |
| XIII | Nintendo GameCube | 2003 | Ubisoft Paris |