| S.C.A.T.: Special Cybernetic Attack Team | Nintendo Entertainment System | 1990 | Winning Entertainment Group |
| Sadness | Wii | — | Nibris |
| Safecracker: The Ultimate Puzzle Adventure | Wii | 2006 | Kheops Studio |
| Sailor Moon | Super Nintendo Entertainment System | 1993 | Bandai |
| Sailor Moon R | Super Nintendo Entertainment System | 1993 | — |
| Sailor Moon S: Jōgai rantō!? Shuyaku sōdatsusen | Super Nintendo Entertainment System | 1994 | Arc System Works |
| Saint Paradise | Game Boy | 1992 | — |
| Saint Seiya : Ougon Densetsu | Nintendo Entertainment System | 1987 | Tose Co. |
| Saint Seiya: Ougon Densetsu Kanketsu Hen | Nintendo Entertainment System | 1988 | Tose Co. |
| Saints Row: Money Shot | Nintendo 3DS | — | THQ |
| Saiyūki World | Nintendo Entertainment System | 1988 | NMK |
| Sakura Wars: So Long, My Love | Wii | 2005 | Sega, Idea Factory, Red Entertainment |
| Salamander | Nintendo Entertainment System | 1986 | Konami |
| Sam & Max Beyond Time and Space | Wii | 2007 | Telltale Games |
| Sam & Max Save the World | Wii | 2006 | Telltale Games |
| Sam & Max: Ice Station Santa | Wii | 2007 | Telltale Games |
| Samba de Amigo | Wii | 2000 | Sonic Team |
| SameGame | Wii | 1985 | Hudson Soft |
| Samurai Defender | Nintendo 3DS | 2013 | — |
| Samurai G | Nintendo 3DS | 2012 | UFO Interactive Games |
| Samurai Jack: The Shadow of Aku | Nintendo GameCube | 2004 | Amaze Entertainment |
| Samurai Shodown | Super Nintendo Entertainment System, Game Boy | 1993 | SNK |
| Samurai Shodown Anthology | Wii | 2008 | SNK |
| Samurai Shodown VI | Wii | 2005 | SNK |
| Samurai Warriors 3 | Wii | 2009 | Koei Tecmo Holdings |
| Samurai Warriors Chronicles 3 | PlayStation Vita, Nintendo 3DS | 2014 | — |
| Samurai Warriors: Chronicles | Nintendo 3DS | 2011 | Koei Tecmo Holdings |
| Samurai Warriors: Katana | Wii | 2007 | Koei Tecmo Holdings |
| San Francisco Rush 2049 | Nintendo GameCube | 1999 | Atari Games, Handheld Games |
| San Francisco Rush: Extreme Racing | Nintendo GameCube | 1997 | Atari Games, Midway Games, Climax Studios |
| Sandy Beach | Wii | 2009 | Frozen Codebase |
| Sangokushi | Nintendo Entertainment System | 1988 | Tose Co. |
| Sangokushi Eiketsuden | Super Nintendo Entertainment System | 1995 | — |
| Sanma no Meitantei | Nintendo Entertainment System | 1987 | Namco |
| Sanrio Characters Picross | Nintendo 3DS | 2018 | Jupiter |
| Sanrio Cup: Pon Pon Volley | Nintendo Entertainment System | 1992 | Character Soft |
| Sanrio World Smash Ball! | Super Nintendo Entertainment System | 1993 | — |
| Sansara Naga | Super Nintendo Entertainment System | 1990 | — |
| Sansara Naga 2 | Super Nintendo Entertainment System | 1994 | — |
| Sansū 2-nen: Keisan Game | Nintendo Entertainment System | 1986 | Tokyo Shoseki |
| Sasa | Nintendo Entertainment System | 1985 | MTL |
| Satoru Nakajima F-1 Hero 2 | Nintendo Entertainment System | 1991 | Human Entertainment |
| Satoru Nakajima F-1 Hero GB World Championship '91 | Game Boy | 1991 | — |
| Saturday Night Slam Masters | Super Nintendo Entertainment System | 1993 | Capcom |
| Sayonara Umihara Kawase | Nintendo 3DS | 2013 | Studio Saizensen |
| Scaler | Nintendo GameCube | 2004 | Behaviour Interactive |
| Scarface: The World Is Yours | Wii | 2006 | Radical Entertainment |
| Scene It? Bright Lights! Big Screen! | Wii | 2009 | Behaviour Interactive |
| Scene It? Twilight | Wii | 2009 | Paramount Digital Entertainment |
| Schlag den Raab | Wii | 2010 | Sproing Interactive Media |
| Schlag den Raab: Das 2. Spiel | Nintendo 3DS, Wii | 2011 | Sproing Interactive Media |
| Scooby-Doo Mystery | Super Nintendo Entertainment System | 1995 | Argonaut Games |
| Scooby-Doo Mystery | Super Nintendo Entertainment System | 1995 | Argonaut Games |
| Scooby-Doo! and the Spooky Swamp | Wii | 2010 | Torus Games |
| Scooby-Doo! First Frights | Wii | 2009 | Torus Games |
| Scooby-Doo! Mystery Mayhem | Nintendo GameCube | 2003 | Behaviour Interactive |
| Scooby-Doo! Night of 100 Frights | Nintendo GameCube | 2002 | Heavy Iron Studios |
| Scooby-Doo! Unmasked | Nintendo GameCube | 2005 | Behaviour Interactive |
| SCORE International Baja 1000 | Wii | 2008 | Left Field Productions |
| Scribblenauts Unlimited | Nintendo 3DS | 2012 | 5th Cell |
| SD Battle Oozumou: Heisei Hero Basho | Nintendo Entertainment System | 1990 | Banpresto |
| SD F-1 Grand Prix | Super Nintendo Entertainment System | 1995 | Video System |
| SD Gundam Gaiden 2: Entaku no Kishi | Super Nintendo Entertainment System | 1992 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari | Nintendo Entertainment System, Game Boy | 1990 | Tose Co. |
| SD Gundam Gaiden: Knight Gundam Monogatari - Ooinaru Isan | Super Nintendo Entertainment System | 1991 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari 2 - Hikari no Kishi | Nintendo Entertainment System | 1991 | Bandai |
| SD Gundam Gaiden: Knight Gundam Monogatari 3 - Densetsu no Kishi Dan | Nintendo Entertainment System, Game Boy | 1992 | Bandai |
| SD Gundam Gaiden: Lacroan Heroes | Game Boy | 1990 | Bandai |
| SD Gundam Gashapon Wars | Nintendo GameCube | 2005 | Bandai Visual |
| SD Gundam Generation: Axis Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Babylonia Kenkoku Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Colony Kaku Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Gryps Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Ichinen Sensouki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam Generation: Zanscare Senki | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam World: Gachapon Senshi - Scramble Wars | Wii | 1987 | Bandai |
| SD Gundam World: Gachapon Senshi - Scramble Wars - Map Collection | Nintendo Entertainment System | 1989 | Bandai |
| SD Gundam World: Gachapon Senshi 2 - Capsule Senki | Nintendo Entertainment System | 1989 | Opera House, Human Entertainment, Bandai |
| SD Gundam World: Gachapon Senshi 3 - Eiyuu Senki | Nintendo Entertainment System | 1990 | Opera House, Bandai |
| SD Gundam World: Gachapon Senshi 4 - New Type Story | Nintendo Entertainment System | 1991 | Tose Co., Bandai |
| SD Gundam World: Gachapon Senshi 5 - Battle of Universal Century | Nintendo Entertainment System | 1992 | Tose Co., Bandai |
| SD Gundam: G Generation Wars | Wii | 2009 | Bandai |
| SD Gundam: G Next | Super Nintendo Entertainment System | 1995 | Bandai |
| SD Gundam: G Next - Unit & map collection | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam: Gundam Wars | Nintendo Entertainment System | 1993 | Bandai |
| SD Gundam: GX | Super Nintendo Entertainment System | 1994 | Bandai |
| SD Gundam: Power Formation Puzzle | Super Nintendo Entertainment System | 1996 | Bandai |
| SD Gundam: Scad Hammers | Wii | 2006 | Bandai |
| SD Gundam: SD Sengokuden - Kunitori Monogatari | Game Boy | 1990 | Bandai |
| SD Gundam: SD Sengokuden 2 - Tenka Touitsu Hen | Game Boy | 1992 | Bandai |
| SD Gundam: SD Sengokuden 3 - Chijou Saikyou Hen | Game Boy | 1992 | Bandai |
| SD Hero Sōkessen: Taose Aku no Gundan | Nintendo Entertainment System | 1990 | Interlink Computer Sciences |
| SD Kidō Senshi Gundam 2 | Super Nintendo Entertainment System | 1993 | Bandai |
| SD Kidō Senshi Gundam: V Sakusen Shidō | Super Nintendo Entertainment System | 1992 | Bandai |
| SD Mobile Suit Gundam | Super Nintendo Entertainment System | 1992 | — |
| SD Rupan Sansei - Kinko yaburi daisakusen | Game Boy | 1990 | — |
| Sea Monsters: A Prehistoric Adventure | Wii | 2007 | Atomic Planet Entertainment |
| SeaQuest DSV | Super Nintendo Entertainment System | 1994 | Sculptured Software |
| Second Sight | Nintendo GameCube | 2004 | Crytek UK |
| Secret Files 2: Puritas Cordis | Wii | 2009 | Animation Arts |
| Secret Files: Tunguska | Wii | 2006 | Animation Arts |
| Secret Mysteries in Amsterdam | Nintendo 3DS | 2012 | Engine Software |
| Secret Mysteries in New York | Nintendo 3DS | 2012 | — |
| Secret of Evermore | Super Nintendo Entertainment System | 1995 | Square |
| Secret of Mana | Super Nintendo Entertainment System, Wii | 1993 | Square |
| Secret of the Stars | Super Nintendo Entertainment System | 1993 | Tecmo |
| Secret Scout in the Temple of Demise | Nintendo Entertainment System | — | Color Dreams |
| Section Z | Nintendo Entertainment System | 1985 | Capcom |
| Sega 3D Classics Collection | Nintendo 3DS | 2014 | M2 |
| Sega Bass Fishing | Wii | 1999 | Sega Wow |
| Sega Soccer Slam | Nintendo GameCube | 2002 | EA Jawbreaker |
| Sega Superstars Tennis | Wii | 2008 | Sumo Digital |
| Seicross | Nintendo Entertainment System | 1984 | Nichibutsu |
| Seifuku Densetsu Pretty Fighter | Super Nintendo Entertainment System | 1994 | Genki |
| Seijuu Maden: Beasts & Blades | Super Nintendo Entertainment System | 1996 | — |
| Seikima II Akuma no Gyakushū! | Nintendo Entertainment System | 1986 | ISCO |
| Sekiryūō | Nintendo Entertainment System | 1989 | Sunsoft |
| Sengoku | Super Nintendo Entertainment System | 1991 | SNK |
| Sengoku Basara 2 | Wii | 2006 | Capcom |
| Sengoku Basara 3 Utage | Wii | 2011 | Capcom |
| Senran Kagura 2: Deep Crimson | Nintendo 3DS | 2014 | Tamsoft |
| Senran Kagura Burst | Nintendo 3DS | 2018 | Tamsoft |
| Senran Kagura: Skirting Shadows | Nintendo 3DS | 2011 | Tamsoft |
| Sensible Soccer | Super Nintendo Entertainment System | 1992 | Sensible Software |
| Serious Sam: Next Encounter | Nintendo GameCube | 2004 | Climax Studios |
| Serpent | Game Boy | 1990 | Kaga Create |
| Sesame Street Countdown | Nintendo Entertainment System | 1992 | Running with Scissors |
| Sesame Street Letters | Nintendo Entertainment System | 1989 | Rare Ltd. |
| Sesame Street: A-B-C/1-2-3 | Nintendo Entertainment System | 1991 | Rare Ltd. |
| Sesame Street: Numbers Count | Nintendo Entertainment System | 1989 | Rare Ltd. |
| Severed | PlayStation Vita, Nintendo 3DS | 2016 | Drinkbox Studios |
| Sexy Poker | Wii | 2009 | Gameloft |
| Sgt. Saunders' Combat! | Super Nintendo Entertainment System | 1995 | — |
| Shadow Brain | Nintendo Entertainment System | 1991 | Scitron & Art Inc. |
| Shadow of the Beast | Super Nintendo Entertainment System | 1989 | Ubisoft Reflections |
| Shadow of the Ninja | Nintendo Entertainment System | 1990 | Winning Entertainment Group |
| Shadow the Hedgehog | Nintendo GameCube | 2005 | Sega |
| Shadowgate | Nintendo Entertainment System | 1987 | ICOM Simulations |
| ShadowPlay | Wii | 2010 | Deep Fried Entertainment |
| Shadowrun | Super Nintendo Entertainment System | 1993 | Krome Studios Melbourne |
| Shake It Up | Wii | 2011 | Papaya Studio |
| Shake It Up 2: Groove It Up | Wii | 2012 | Papaya Studio |
| Shakedown: Hawaii | PlayStation Vita, Nintendo 3DS, Wii | 2019 | Vblank Entertainment |
| Shaman King: Soul Fight | Nintendo GameCube | 2003 | — |
| Shamu's Deep Sea Adventures | Nintendo GameCube | 2005 | Activision |
| Shamus | Game Boy | 1982 | — |
| Shanghai | Nintendo Entertainment System | 1986 | Sunsoft |
| Shanghai III | Super Nintendo Entertainment System | 1993 | Success, Kuusoukagaku, Sunsoft |
| Shantae | Nintendo 3DS | 2002 | WayForward Technologies |
| Shantae and the Pirate's Curse | Nintendo 3DS | 2014 | WayForward Technologies |
| Shaq Fu | Super Nintendo Entertainment System, Game Boy | 1994 | Delphine Software International |
| Shark Tale | Nintendo GameCube | 2004 | Edge of Reality |
| Shatterhand | Nintendo Entertainment System | 1991 | Winning Entertainment Group |
| Shaun White Skateboarding | Wii | 2010 | Ubisoft Montreal |
| Shaun White Snowboarding | Wii | 2008 | Ubisoft Montreal |
| Shaun White Snowboarding: Road Trip | Wii | 2008 | 2K China |
| Shaun White Snowboarding: World Stage | Wii | 2009 | Ubisoft Montreal |
| Sherlock Holmes and the Mystery of the Frozen City | Nintendo 3DS | 2012 | Frogwares |
| Sherlock Holmes: Hakushaku Reijō Yūkai Jiken | Nintendo Entertainment System | 1986 | Towa Chiki |
| Sherlock Holmes: The Mystery of the Mummy | Wii | 2002 | Frogwares |
| Shien's Revenge | Super Nintendo Entertainment System | 1994 | Givro |
| Shifting World | Nintendo 3DS | 2012 | — |
| Shigetaka Kashiwagi's Top Water Bassing | Super Nintendo Entertainment System | 1995 | — |
| Shijō Saikyō League Serie A: Ace Striker | Super Nintendo Entertainment System | 1995 | — |
| Shikinjoh | Nintendo Entertainment System | 1991 | Sunsoft |
| Shimano Xtreme Fishing | Wii | 2009 | EV Interactive |
| Shin Kidō Senki Gundam Wing: Endless Duel | Super Nintendo Entertainment System | 1996 | Winning Entertainment Group |
| Shin Megami Tensei | Super Nintendo Entertainment System | 1992 | Atlus |
| Shin Megami Tensei If… | Super Nintendo Entertainment System | 1994 | Atlus |
| Shin Megami Tensei II | Super Nintendo Entertainment System | 1994 | Atlus |
| Shin Megami Tensei IV | Nintendo 3DS | 2013 | Atlus |
| Shin Megami Tensei IV: Apocalypse | Nintendo 3DS | 2016 | Atlus |
| Shin Megami Tensei: Devil Survivor 2 Record Breaker | Nintendo 3DS | 2015 | — |
| Shin Megami Tensei: Devil Survivor Overclocked | Nintendo 3DS | 2011 | — |
| Shin Megami Tensei: Strange Journey Redux | Nintendo 3DS | 2017 | Atlus |
| Shin Momotaro Densetsu | Super Nintendo Entertainment System | 1993 | — |
| Shin Nekketsu Kōha: Kunio-tachi no Banka | Super Nintendo Entertainment System | 1994 | Givro |
| Shin Onigashima | Super Nintendo Entertainment System | 1987 | Nintendo Entertainment Analysis & Development, Pax Softnica |
| Shin SD Gundam Gaiden | Game Boy | 1994 | — |
| Shin SD Gundam Gaiden: Knight Gundam Monogatari | Game Boy | 1994 | Bandai |
| Shin SD Sengokuden: Daishōgun Retsuden | Super Nintendo Entertainment System | — | Bandai |
| Shin Seikoku: La Wares | Super Nintendo Entertainment System | 1995 | — |
| Shingen the Ruler | Nintendo Entertainment System | 1989 | Another |
| Shinobi | Nintendo Entertainment System | 1987 | Sega |
| Shinobi | Nintendo 3DS | 2011 | Griptonite Games |
| Shinseiki GPX Cyber Formula: Road to the Evolution | Nintendo GameCube | 2004 | Sunrise Interactive |
| Shinseiki Odysselya | Super Nintendo Entertainment System | 1993 | — |
| Shinseiki Odysselya II | Super Nintendo Entertainment System | 1995 | — |
| Shippū! Iron Leaguer | Game Boy | 1994 | — |
| Shiren the Wanderer | Wii | 2008 | Chunsoft |
| Shiroi Ringu he | Super Nintendo Entertainment System | 1995 | — |
| Shockwave | Nintendo Entertainment System | 1990 | American Game Cartridges |
| Shodai Nekketsu Kouha Kunio-Kun | Super Nintendo Entertainment System | 1992 | — |
| Shoot the Ball | Nintendo 3DS | 2016 | RCMADIAX |
| Shooting Range | Nintendo Entertainment System | 1989 | Tose Co. |
| Short Order / Eggsplode! | Nintendo Entertainment System | 1989 | Tose Co. |
| Shovel Knight | PlayStation Vita, Nintendo 3DS | 2014 | Yacht Club Games |
| Shovel Knight: Specter of Torment | Nintendo 3DS | 2017 | Yacht Club Games |
| Shovel Knight: Treasure Trove | PlayStation Vita, Nintendo 3DS | 2014 | Yacht Club Games |
| Showtime Championship Boxing | Wii | 2007 | Nikitova Games |
| Shrek | Nintendo GameCube | 2001 | DICE |
| Shrek 2 | Nintendo GameCube | 2004 | KnowWonder |
| Shrek Extra Large | Nintendo GameCube | 2002 | DICE |
| Shrek Forever After | Wii | 2010 | XPEC Entertainment |
| Shrek Smash n' Crash Racing | Nintendo GameCube | 2006 | Torus Games |
| Shrek Super Party | Nintendo GameCube | 2002 | Mass Media Inc. |
| Shrek SuperSlam | Nintendo GameCube | 2005 | 7 Studios, Shaba Games |
| Shrek the Third | Wii | 2007 | Shaba Games |
| Shrek's Carnival Craze | Wii | 2008 | Nordcurrent |
| Shuffle Fight | Nintendo Entertainment System | 1992 | Pandora Box |
| Shufflepuck Café | Nintendo Entertainment System | 1989 | Broderbund |
| Shutokō Battle '94: Drift King Tsuchiya Keiichi & Bandō Masaaki | Super Nintendo Entertainment System | 1994 | Genki |
| Shuyaku Sentai Irem Fighter | Game Boy | 1993 | Irem |
| Shōgi Saikyō | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Shōnin yo Taishi wo Idake!! | Super Nintendo Entertainment System | 1995 | Fortyfive |
| Sid Meier's Pirates! | Wii | 2004 | Firaxis Games |
| Sid Meier's Pirates! | Nintendo Entertainment System, Apple II series | 1987 | MicroProse |
| Side Pocket | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1986 | Data East |
| Silent Assault | Nintendo Entertainment System | 1990 | Thin Chen Enterprise |
| Silent Hill: Shattered Memories | Wii | 2009 | Climax Studios |
| Silent Service | Nintendo Entertainment System | 1985 | MicroProse |
| Silk Worm | Nintendo Entertainment System | 1988 | Tecmo |
| Silva Saga II: The Legend of Light and Darkness | Super Nintendo Entertainment System | 1993 | SETA Corporation |
| Silver Star Chess | Wii | 2008 | Agetec |
| Silver Star Reversi | Wii | 2008 | Agetec |
| Silver Surfer | Nintendo Entertainment System | 1990 | Software Creations |
| Sim City | Nintendo Entertainment System, Super Nintendo Entertainment System, Wii | 1991 | Electronic Arts |
| SimAnimals | Wii | 2009 | Electronic Arts |
| SimAnt | Super Nintendo Entertainment System | 1991 | Maxis |
| SimCity | Super Nintendo Entertainment System, Wii | 1989 | Nintendo Entertainment Analysis & Development, Maxis |
| SimCity 2000 | Super Nintendo Entertainment System | 1993 | Maxis, Full Fat |
| SimCity Creator | Wii | 2008 | Hudson Soft |
| SimEarth | Super Nintendo Entertainment System, Wii | 1990 | Maxis |
| Simple Series Vol. 4: The Misshitsu kara no Dasshutsu | Wii | 2009 | INTENSE |
| SimTown | Super Nintendo Entertainment System | 1995 | Maxis |
| Simulation Pro Yakyū | Super Nintendo Entertainment System | 1995 | Hect |
| Sin & Punishment: Star Successor | Wii | 2009 | Treasure |
| Sink or Swim | Super Nintendo Entertainment System | 1993 | Eutechnyx |
| Sir Ababol | Nintendo Entertainment System | 2012 | — |
| Skate It | Wii | 2008 | EA Montreal |
| Skate or Die 2: The Search for Double Trouble | Nintendo Entertainment System | 1990 | Electronic Arts |
| Skate or Die! | Nintendo Entertainment System | 1987 | Electronic Arts |
| Skate or Die: Bad 'N Rad | Game Boy | — | Konami |
| Skate or Die: Tour de Thrash | Game Boy | 1991 | Electronic Arts |
| Ski or Die | Nintendo Entertainment System | 1990 | Electronic Arts |
| Ski-Doo: Snowmobile Challenge | Wii | 2009 | Coldwood Interactive |
| Skies of Arcadia | Nintendo GameCube | 2000 | Sega Wow |
| Skull & Crossbones | Nintendo Entertainment System | 1987 | Atari Games |
| Sky Destroyer | Nintendo Entertainment System | 1985 | Magical Company |
| Sky Kid | Nintendo Entertainment System | 1985 | Namco |
| Sky Mission | Super Nintendo Entertainment System | 1992 | — |
| Skyblazer | Super Nintendo Entertainment System | 1994 | Ukiyotei |
| Skylanders: Giants | Nintendo 3DS, Wii | 2012 | Toys for Bob |
| Skylanders: Spyro's Adventure | Nintendo 3DS, Wii | 2011 | Toys for Bob |
| Skylanders: Swap Force | Nintendo 3DS, Wii | 2013 | Blizzard Albany |
| Skylanders: Trap Team | Nintendo 3DS | 2014 | Toys for Bob |
| Sküljagger: Revolt of the Westicans | Super Nintendo Entertainment System | 1992 | ASC Games |
| Slalom | Nintendo Entertainment System | 1987 | Rare Ltd. |
| Slam Dunk | Super Nintendo Entertainment System, Game Boy | 1994 | Tose Co. |
| Slam Dunk 2: IH Yosen Kanzenban!! | Super Nintendo Entertainment System, Game Boy | 1995 | — |
| Slayers | Super Nintendo Entertainment System | 1994 | — |
| Sled Shred featuring the Jamaican Bobsled Team | Wii | 2010 | — |
| Slice It! | Nintendo 3DS | — | Com2uS |
| Slime Mori Mori Dragon Quest 3 | Nintendo 3DS | 2011 | Square Enix |
| Small Soldiers | Game Boy | 1998 | — |
| Smart Ball | Super Nintendo Entertainment System | 1991 | Game Freak |
| Smarty Pants | Wii | 2007 | Planet Moon Studios |
| Smash Tennis | Super Nintendo Entertainment System | 1993 | Namco |
| Smash TV | Nintendo Entertainment System, Super Nintendo Entertainment System | 1990 | WMS Industries |
| Smashing Drive | Nintendo GameCube | 2002 | Gaelco |
| Smuggler's Run | Nintendo GameCube | 2000 | Rebellion Developments, Rockstar San Diego |
| Smuggler's Run: Warzones | Nintendo GameCube | 2002 | Rockstar San Diego |
| Snake Rattle 'n' Roll | Nintendo Entertainment System | 1990 | Rare Ltd. |
| Snake's Revenge | Nintendo Entertainment System | 1990 | Konami |
| Sneaky Snakes | Game Boy | — | Rare Ltd. |
| Sniper Elite | Wii | 2005 | Rebellion Developments |
| SNK Arcade Classics Vol. 1 | Wii | 2008 | Terminal Reality |
| Snoopy Concert | Super Nintendo Entertainment System | 1995 | Pax Softnica |
| Snoopy's Magic Show | Game Boy | 1990 | Kemco |
| Snoopy's Silly Sports Spectacular | Nintendo Entertainment System | 1988 | Kemco |
| Snow Bros.: Nick and Tom | Nintendo Entertainment System, Game Boy | 1990 | Toaplan |
| Snow White: Happily Ever After | Super Nintendo Entertainment System | 1994 | ASC Games |
| Snowboard Riot | Wii | 2009 | Hudson Soft |
| Snowpack Park | Wii | 2010 | skip Ltd. |
| So Blonde | Wii | 2008 | Wizarbox |
| So Blonde: Back to the Island | Wii | 2010 | Wizarbox |
| Soccer | Nintendo Entertainment System | 1985 | Intelligent Systems |
| Soccer | Game Boy | 1991 | Tose Co. |
| Soccer Kid | Super Nintendo Entertainment System | 1993 | Krisalis Software |
| Soccer Mania | Game Boy | 1990 | — |
| Socks the Cat Rocks the Hill | Super Nintendo Entertainment System | 1993 | Kaneko |
| Solar Jetman | Nintendo Entertainment System | 1990 | Zippo Games |
| Solar Striker | Game Boy | 1990 | Nintendo Research & Development 1 |
| Soldam | Game Boy | 1992 | Jaleco |
| Solid Runner | Super Nintendo Entertainment System | 1997 | Sting |
| Solomon's Club | Game Boy | 1991 | — |
| Solomon's Key | Nintendo Entertainment System | 1986 | Tecmo |
| Solomon's Key 2 | Nintendo Entertainment System | 1992 | Tecmo |
| Solstice | Nintendo Entertainment System | 1990 | Software Creations |
| Solvalou | Wii | 1991 | Namco |
| Somari | Nintendo Entertainment System | 1994 | Hummer Team, Dendy |
| Song Master | Super Nintendo Entertainment System | 1992 | Japan Art Media |
| Sonic & All-Stars Racing Transformed | PlayStation Vita, Nintendo 3DS | 2012 | Sumo Digital |
| Sonic & Knuckles | Nintendo GameCube, Wii | 1994 | Sonic Team |
| Sonic & Sega All-Stars Racing | Wii | 2010 | Sumo Digital |
| Sonic 3 & Knuckles | Nintendo GameCube | 1994 | Sonic Team |
| Sonic Adventure | Nintendo GameCube | 1998 | Sonic Team, Now Production |
| Sonic Adventure 2 | Nintendo GameCube | 2001 | Sonic Team |
| Sonic Adventure 2: Battle | Nintendo GameCube | 2002 | Sonic Team |
| Sonic Adventure DX: Director's Cut | Nintendo GameCube | 2003 | Sonic Team |
| Sonic and the Black Knight | Wii | 2009 | Sonic Team |
| Sonic and the Secret Rings | Wii | 2007 | Sonic Team |
| Sonic Blast Man | Super Nintendo Entertainment System | 1992 | Taito |
| Sonic Blast Man II | Super Nintendo Entertainment System | 1994 | — |
| Sonic Boom | Nintendo 3DS | 2014 | — |
| Sonic Boom: Fire & Ice | Nintendo 3DS | 2016 | Sanzaru Games |
| Sonic Boom: Shattered Crystal | Nintendo 3DS | 2014 | Sanzaru Games |
| Sonic Colors | Wii | 2010 | Sonic Team |
| Sonic Gems Collection | Nintendo GameCube | 2005 | Sonic Team |
| Sonic Generations | Nintendo 3DS | 2011 | Sonic Team, Dimps |
| Sonic Heroes | Nintendo GameCube | 2003 | Sonic Team |
| Sonic Lost World | Nintendo 3DS | 2013 | Sonic Team |
| Sonic Mega Collection | Nintendo GameCube | 2002 | Sonic Team |
| Sonic Riders | Nintendo GameCube | 2006 | Sonic Team |
| Sonic Riders: Zero Gravity | Wii | 2008 | Sonic Team |
| Sonic the Fighters | Nintendo GameCube | 1996 | Sega AM2 |
| Sonic the Hedgehog | Nintendo GameCube, Nintendo 3DS, Wii | 1991 | Sonic Team, Konami |
| Sonic the Hedgehog 2 | Nintendo GameCube, Nintendo 3DS | 1992 | Sonic Team |
| Sonic the Hedgehog 3 | Nintendo 3DS | 1994 | Sonic Team |
| Sonic the Hedgehog 4 | Super Nintendo Entertainment System | 1996 | — |
| Sonic the Hedgehog 4: Episode I | Wii | 2010 | Sonic Team |
| Sonic the Hedgehog CD | Nintendo GameCube | 1993 | Sonic Team |
| Sonic Unleashed | Wii | 2008 | Sonic Team |
| SonSon | Nintendo Entertainment System | 1984 | Capcom |
| Sorcerian | Wii | 1987 | Aeria, Nihon Falcom, Sega, G-Mode |
| Sorcery Blade | Wii | 2008 | WorldWideSoftware |
| Soreyuke Ebisumaru Karakuri: Meiro Kieta Goemon no Nazo | Super Nintendo Entertainment System | 1996 | — |
| SOS | Super Nintendo Entertainment System | 1993 | Human Entertainment |
| Sougou Kakutougi Rings: Astral Bout 3 | Super Nintendo Entertainment System | 1995 | — |
| Sougou Kakutougi: Astral Bout 2 - The Total Fighters | Super Nintendo Entertainment System | 1994 | — |
| Soukou Kihei Votoms: The Battling Road | Super Nintendo Entertainment System | 1993 | — |
| Soul & Sword | Super Nintendo Entertainment System | 1993 | — |
| Soul Blazer | Super Nintendo Entertainment System | 1992 | Quintet |
| Soul Eater: Monotone Princess | Wii | 2008 | Square Enix |
| Soulcalibur II | Nintendo GameCube | 2002 | Project Soul |
| Soulcalibur Legends | Wii | 2007 | Project Soul |
| Sound Fantasy | Super Nintendo Entertainment System | — | Nintendo |
| Sound Novel Tsukūru | Super Nintendo Entertainment System | 1996 | Success, ASCII Corporation |
| Space Ace | Super Nintendo Entertainment System | 1984 | RDI Video Systems |
| Space Ace | Super Nintendo Entertainment System | 1994 | Oxford Digital Enterprises Ltd |
| Space Chimps | Wii | 2008 | Redtribe |
| Space Football: One on One | Super Nintendo Entertainment System | 1992 | Bits Studios |
| Space Harrier | Nintendo Entertainment System, Nintendo 3DS | 1985 | Sega AM2 |
| Space Hunter | Nintendo Entertainment System | 1986 | Kemco |
| Space Intervention | Nintendo 3DS | 2021 | — |
| Space Invaders | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1978 | Taito |
| Space Invaders DX | Super Nintendo Entertainment System | 1994 | — |
| Space Invaders Get Even | Wii | 2008 | Taito |
| Space Invaders: Fukkatsu no Hi | Wii | 1990 | Taito |
| Space Megaforce | Super Nintendo Entertainment System | 1992 | Compile |
| Space Raiders | Nintendo GameCube | 2002 | Taito |
| Space Shuttle Project | Nintendo Entertainment System | 1991 | Imagineering |
| Space Station Tycoon | Wii | — | Wahoo Studios |
| Spaceball Revolution | Wii | 2009 | Virtual Toys |
| Spanky's Quest | Super Nintendo Entertainment System, Game Boy | 1991 | Winning Entertainment Group |
| Sparkster | Super Nintendo Entertainment System | 1994 | Konami |
| Sparkster: Rocket Knight Adventures 2 | Super Nintendo Entertainment System | 1994 | Konami |
| Spartan X 2 | Nintendo Entertainment System | 1991 | Irem |
| Spartan: Total Warrior | Nintendo GameCube | 2005 | Creative Assembly |
| Spawn: Armageddon | Nintendo GameCube | 2003 | Point of View, Inc. |
| Spear of Destiny | Super Nintendo Entertainment System | 1992 | id Software |
| Special Jinsei Game | Nintendo GameCube | 2003 | Takara |
| Spectre | Super Nintendo Entertainment System | 1991 | — |
| Spectrobes: Origins | Wii | 2009 | Genki |
| Speed Challenge: Jacques Villeneuve's Racing Vision | Nintendo GameCube | 2002 | Ubisoft |
| Speed Kings | Nintendo GameCube | 2003 | Climax Studios |
| Speed Racer in My Most Dangerous Adventures | Super Nintendo Entertainment System | 1994 | Radical Entertainment |
| Speed Racer: The Videogame | Wii | 2008 | Sidhe |
| Speedball | Game Boy | 1988 | The Bitmap Brothers |
| Speedy Gonzales | Game Boy | 1993 | — |
| Speedy Gonzales: Aztec Adventure | Game Boy | 1999 | Sunsoft |
| Speedy Gonzales: Los Gatos Bandidos | Super Nintendo Entertainment System | 1995 | Sunsoft |
| Spellcraft: Aspects of Valor | Super Nintendo Entertainment System | 1992 | — |
| Spelunker | Nintendo Entertainment System | 1985 | MicroGraphic Image |
| Spelunker II: Yūsha e no Chōsen | Nintendo Entertainment System | 1987 | Now Production |
| Sphinx and the Cursed Mummy | Nintendo GameCube | 2003 | THQ Nordic, Eurocom |
| Spider-Man | Nintendo GameCube | 2002 | Treyarch, Gray Matter Interactive |
| Spider-Man 2 | Nintendo GameCube | 2004 | Treyarch |
| Spider-Man 3 | Wii | 2007 | Blizzard Albany, Treyarch |
| Spider-Man 3: Invasion of the Spider-Slayers | Game Boy | 1993 | Bits Studios |
| Spider-Man and the X-Men in Arcade's Revenge | Super Nintendo Entertainment System, Game Boy | 1993 | Software Creations |
| Spider-Man and Venom: Maximum Carnage | Super Nintendo Entertainment System | 1994 | Software Creations |
| Spider-Man Animated Series | Super Nintendo Entertainment System | 1995 | — |
| Spider-Man: Edge of Time | Nintendo 3DS, Wii | 2011 | Beenox |
| Spider-Man: Friend or Foe | Wii | 2007 | Next Level Games |
| Spider-Man: Return of the Sinister Six | Nintendo Entertainment System | 1992 | Bits Studios |
| Spider-Man: Shattered Dimensions | Wii | 2010 | Beenox |
| Spider-Man: Web of Shadows | Wii | 2008 | Shaba Games |
| Spindizzy Worlds | Super Nintendo Entertainment System | 1992 | — |
| Spirit Camera: The Cursed Memoir | Nintendo 3DS | 2012 | Koei Tecmo Holdings |
| Spirou | Super Nintendo Entertainment System | 1995 | Infogrames |
| Splatterhouse: Wanpaku Graffiti | Nintendo Entertainment System | 1989 | Now Production |
| SPOGS Racing | Wii | 2008 | Pronto Games |
| SpongeBob HeroPants | PlayStation Vita, Nintendo 3DS | 2015 | Behaviour Interactive |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | Wii | 2008 | Incinerator Studios |
| SpongeBob SquarePants: Battle for Bikini Bottom | Nintendo GameCube | 2003 | Heavy Iron Studios |
| SpongeBob SquarePants: Creature from the Krusty Krab | Nintendo GameCube, Wii | 2006 | Blitz Games |
| SpongeBob SquarePants: Lights, Camera, Pants! | Nintendo GameCube | 2005 | THQ |
| SpongeBob SquarePants: Plankton's Robotic Revenge | Nintendo 3DS, Wii | 2013 | Behaviour Interactive |
| SpongeBob SquarePants: Revenge of the Flying Dutchman | Nintendo GameCube | 2002 | Blizzard Albany |
| SpongeBob SquigglePants | Nintendo 3DS, Wii | 2011 | WayForward Technologies |
| SpongeBob's Atlantis SquarePantis | Wii | 2007 | Blitz Games |
| SpongeBob's Boating Bash | Wii | 2010 | Firebrand Games |
| SpongeBob's Truth or Square | Wii | 2009 | Heavy Iron Studios |
| Spore Hero | Wii | 2009 | EA Montreal |
| Sports Collection | Game Boy | 1996 | Tose Co. |
| Sports Illustrated: Championship Football & Baseball | Super Nintendo Entertainment System | 1993 | Malibu Comics |
| Sports Island 3D | Nintendo 3DS | 2011 | — |
| Spot: The Cool Adventure | Game Boy | 1994 | Visual Concepts |
| Spot: The Video Game | Nintendo Entertainment System, Game Boy | 1990 | Visual Concepts, Virgin Interactive |
| SPRay | Wii | 2008 | Eko Software |
| Spriggan Powered | Super Nintendo Entertainment System | 1996 | Micronics |
| Springdale: Riding Adventures | Wii | 2010 | Pixel Tales, Hidden Entertainment |
| Sprinter Monogatari: Mezase!! Ikkaku Senkin | Super Nintendo Entertainment System | 1995 | VAP Inc. |
| Spud's Adventure | Game Boy | 1991 | Atlus |
| Spy Fox in "Dry Cereal" | Wii | 1997 | Humongous Entertainment |
| Spy Games: Elevator Mission | Wii | 2007 | Dreams Co., Ltd. |
| Spy Hunter | Nintendo Entertainment System, Nintendo GameCube | 1983 | Midway Games |
| Spy Hunter | Nintendo GameCube | 2001 | Paradigm Entertainment |
| Spy Hunter | PlayStation Vita, Nintendo 3DS | 2012 | TT Fusion |
| Spy vs. Spy | Nintendo Entertainment System, Game Boy | 1984 | Aackosoft, First Star Software |
| Spy vs. Spy: The Island Caper | Nintendo Entertainment System | 1985 | Aackosoft |
| Spyborgs | Wii | 2009 | Bionic Games |
| Spyro: A Hero's Tail | Nintendo GameCube | 2004 | Eurocom |
| Spyro: Enter the Dragonfly | Nintendo GameCube | 2002 | — |
| Sqoon | Nintendo Entertainment System | 1986 | Magical Company |
| Square Deal: The Game of Two Dimensional Poker | Nintendo Entertainment System, Game Boy | 1990 | Human Engineered Software, Hect |
| Square's Tom Sawyer | Nintendo Entertainment System | 1989 | Square |
| Squids Odyssey | Nintendo 3DS | 2014 | The Game Bakers |
| SSX 3 | Nintendo GameCube | 2003 | EA Vancouver |
| SSX Blur | Wii | 2007 | EA Montreal |
| SSX On Tour | Nintendo GameCube | 2005 | EA Vancouver |
| SSX Tricky | Nintendo GameCube | 2001 | EA Vancouver |
| St Andrews: Eikō to Rekishi no Old Course | Super Nintendo Entertainment System | 1995 | — |
| Stack-Up | Nintendo Entertainment System | 1985 | Nintendo Research & Development 1 |
| Stadium Events | Nintendo Entertainment System | 1986 | Bandai |
| Stanley: The Search for Dr. Livingston | Nintendo Entertainment System | 1992 | Sculptured Software |
| Star Force | Nintendo Entertainment System | 1984 | Koei Tecmo Holdings |
| Star Fox | Super Nintendo Entertainment System | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| Star Fox 2 | Super Nintendo Entertainment System | 2017 | Nintendo |
| Star Fox 64 | Wii | 1997 | Nintendo Entertainment Analysis & Development |
| Star Fox 64 3D | Nintendo 3DS | 2011 | Q-Games, Nintendo Entertainment Analysis & Development |
| Star Fox Adventures | Nintendo GameCube | 2002 | Rare Ltd. |
| Star Fox: Assault | Nintendo GameCube | 2005 | Bandai Namco Entertainment |
| Star Fox: Super Weekend | Super Nintendo Entertainment System | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| Star Luster | Nintendo Entertainment System | 1985 | Namco |
| Star Ocean | Super Nintendo Entertainment System | 1996 | tri-Ace |
| Star Soldier | Nintendo Entertainment System | 1986 | Hudson Soft |
| Star Trek Prodigy: Supernova | Game Boy | 2022 | Tessera Studios |
| Star Trek: 25th Anniversary | Nintendo Entertainment System | 1991 | Interplay Entertainment |
| Star Trek: 25th Anniversary | Game Boy | 1992 | Visual Concepts |
| Star Trek: Conquest | Wii | 2007 | 4J Studios |
| Star Trek: Deep Space Nine – Crossroads of Time | Super Nintendo Entertainment System | 1995 | Appaloosa Interactive |
| Star Trek: Starfleet Academy – Starship Bridge Simulator | Super Nintendo Entertainment System | 1994 | High Voltage Software |
| Star Trek: Tactical Assault | Game Boy | 2006 | Quicksilver Software |
| Star Trek: The Next Generation | Nintendo Entertainment System, Game Boy | 1993 | Absolute Entertainment |
| Star Trek: The Next Generation: Future's Past | Super Nintendo Entertainment System | 1994 | Spectrum HoloByte |
| Star Voyager | Nintendo Entertainment System | 1986 | ASCII Corporation |
| Star Wars | Nintendo Entertainment System | 1987 | Namco |
| Star Wars | Nintendo Entertainment System, Game Boy | 1991 | Lucasfilm Games, Krome Studios Melbourne, NMS Software, Tiertex Design Studios |
| Star Wars Jedi Knight II: Jedi Outcast | Nintendo GameCube | 2002 | Raven Software |
| Star Wars Rogue Squadron II: Rogue Leader | Nintendo GameCube | 2001 | Factor 5 |
| Star Wars Rogue Squadron III: Rebel Strike | Nintendo GameCube | 2003 | Factor 5 |
| Star Wars: Bounty Hunter | Nintendo GameCube | 2002 | Lucasfilm Games |
| Star Wars: The Clone Wars | Nintendo GameCube | 2002 | Pandemic Studios |
| Star Wars: The Clone Wars – Lightsaber Duels | Wii | 2008 | Krome Studios |
| Star Wars: The Clone Wars – Republic Heroes | Wii | 2009 | Krome Studios |
| Star Wars: The Empire Strikes Back | Nintendo Entertainment System, Game Boy | 1992 | Lucasfilm Games, Sculptured Software |
| Star Wars: The Force Unleashed | Wii | 2008 | Lucasfilm Games |
| Star Wars: The Force Unleashed II | Wii | 2010 | Lucasfilm Games |
| Stardew Valley | PlayStation Vita, Nintendo 3DS | 2016 | ConcernedApe LLC, Eric Barone |
| Stargate | Super Nintendo Entertainment System | 1994 | Acclaim Studios London |
| Stargate | Nintendo Entertainment System | 1981 | Vid Kidz |
| Stargate | Game Boy | 1994 | — |
| Starship Hector | Nintendo Entertainment System | 1987 | Hudson Soft |
| Starsky & Hutch | Nintendo GameCube | 2003 | Mind's Eye Productions |
| Starsweep | Game Boy | 1997 | — |
| StarTropics | Nintendo Entertainment System | 1990 | Nintendo Integrated Research & Development |
| Stealth | Super Nintendo Entertainment System | 1992 | — |
| Stealth ATF | Nintendo Entertainment System | 1989 | Imagineering |
| SteamWorld Dig | PlayStation Vita, Nintendo 3DS | 2013 | Image & Form |
| SteamWorld Dig 2 | Nintendo 3DS | 2017 | Image & Form |
| SteamWorld Heist | PlayStation Vita, Nintendo 3DS | 2015 | Image & Form |
| Steel Diver | Nintendo 3DS | 2011 | Nintendo Entertainment Analysis & Development |
| Steel Diver: Sub Wars | Nintendo 3DS | 2014 | Nintendo |
| Steel Talons | Super Nintendo Entertainment System | 1991 | Atari Games |
| Stella Glow | Nintendo 3DS | 2015 | Imageepoch |
| Sterling Sharpe: End 2 End | Super Nintendo Entertainment System | 1995 | Tose Co. |
| Stinger | Nintendo Entertainment System | 1986 | Konami |
| Stone Protectors | Super Nintendo Entertainment System | 1994 | Eurocom |
| Stop That Roach! | Game Boy | 1994 | — |
| Storm Chaser: Tornado Alley | Game Boy, Nintendo 3DS | 2018 | Skunk Software |
| Story of Seasons | Nintendo 3DS | 2014 | Marvelous |
| Story of Seasons: Trio of Towns | Nintendo 3DS | 2016 | Marvelous |
| Streemerz | Nintendo Entertainment System | 2010 | — |
| Street Cop | Nintendo Entertainment System | 1987 | Human Entertainment |
| Street Fighter 2010: The Final Fight | Nintendo Entertainment System, Nintendo 3DS | 1990 | Capcom |
| Street Fighter Alpha 2 | Super Nintendo Entertainment System | 1996 | Capcom |
| Street Fighter II | Super Nintendo Entertainment System, Game Boy, Wii | 1991 | Capcom |
| Street Fighter II Turbo | Super Nintendo Entertainment System | 1992 | Capcom |
| Street Fighter II: Champion Edition | Super Nintendo Entertainment System | 1992 | Capcom |
| Street Football 2 | Wii | 2009 | Dehon Games |
| Street Hockey '95 | Super Nintendo Entertainment System | 1994 | GTE Interactive Media |
| Street Hoops | Nintendo GameCube | 2002 | Black Ops Entertainment |
| Street Racer | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Street Racing Syndicate | Nintendo GameCube | 2004 | Eutechnyx |
| StreetPass Mii Plaza | Nintendo 3DS | 2011 | Nintendo Software Planning & Development |
| Stretchmo | Nintendo 3DS | 2015 | Intelligent Systems |
| Strider | Wii | 1989 | Capcom |
| Strider | Nintendo Entertainment System | 1989 | Capcom |
| Strike Force Bowling | Nintendo GameCube | 2004 | — |
| Strike Gunner S.T.G | Super Nintendo Entertainment System | 1992 | Athena |
| Striker | Super Nintendo Entertainment System | 1992 | Rage Games |
| Strong Bad's Cool Game for Attractive People: Season 1 | Wii | 2008 | Telltale Games |
| Strong Badia the Free | Wii | 2008 | Telltale Games |
| Stubbs the Zombie in Rebel Without a Pulse | Wii | 2005 | Wideload Games |
| Stunt Flyer: Hero of the Skies | Wii | 2010 | Nice Ideas |
| Stunt Kids | Nintendo Entertainment System | — | Codemasters |
| Stunt Race FX | Super Nintendo Entertainment System | 1994 | Nintendo Entertainment Analysis & Development |
| Style Savvy: Fashion Forward | Nintendo 3DS | 2015 | Syn Sophia |
| Style Savvy: Styling Star | Nintendo 3DS | 2017 | Syn Sophia |
| Style Savvy: Trendsetters | Nintendo 3DS | 2012 | Syn Sophia |
| Sudoku Challenge! | Wii | 2008 | Digital Leisure |
| Sudokuball Detective | Wii | 2009 | White Bear BV, CreaVate |
| Sugoi Hebereke | Super Nintendo Entertainment System | 1994 | Sunsoft, OLM, Inc. |
| Sugoro Quest++: Dicenics | Super Nintendo Entertainment System | 1994 | — |
| Sugoro Quest: Dice Heroes | Nintendo Entertainment System | 1991 | Technōs Japan |
| Sugoroku Ginga Senki | Super Nintendo Entertainment System | 1996 | Bottom Up |
| Sukeban Shachou Rena | Wii | 2009 | Jorudan |
| Summer Athletics | Wii | 2008 | 49Games |
| Summer Athletics 2009 | Wii | 2009 | 49Games |
| Summer Sports: Paradise Island | Wii | 2008 | Destineer |
| Summoner 2 | Nintendo GameCube | 2002 | Volition |
| Sumo Fighter: Tōkaidō Basho | Game Boy | 1991 | KID |
| Sunday Funday | Nintendo Entertainment System | 1995 | Color Dreams |
| Sunman | Nintendo Entertainment System | 1992 | EIM |
| Sunny Garcia Surfing | Nintendo GameCube | 2001 | Krome Studios |
| Sunset Riders | Super Nintendo Entertainment System | 1991 | Konami |
| Sunsoft Grand Prix | Game Boy | 1990 | — |
| Super 3D Noah's Ark | Super Nintendo Entertainment System | 1994 | Wisdom Tree |
| Super Adventure Island | Super Nintendo Entertainment System | 1992 | Produce! |
| Super Adventure Island II | Super Nintendo Entertainment System | 1994 | Hudson Soft |
| Super Air Diver | Super Nintendo Entertainment System | 1993 | — |
| Super Back to the Future Part II | Super Nintendo Entertainment System | 1993 | GameFAQs |
| Super Baseball Simulator 1.000 | Super Nintendo Entertainment System | 1991 | Culture Brain |
| Super Bases Loaded | Super Nintendo Entertainment System | 1991 | Tose Co. |
| Super Bases Loaded 2 | Super Nintendo Entertainment System | 1993 | Tose Co. |
| Super Bases Loaded 3 | Super Nintendo Entertainment System | 1994 | Tose Co. |
| Super Batter Up | Super Nintendo Entertainment System | 1992 | — |
| Super Battleship | Super Nintendo Entertainment System | 1993 | — |
| Super Battletank | Super Nintendo Entertainment System | 1992 | Imagineering |
| Super Battletank 2 | Super Nintendo Entertainment System | 1994 | Imagineering |
| Super Bikkuriman | Super Nintendo Entertainment System | 1993 | Bandai |
| Super Birdie Rush | Super Nintendo Entertainment System | 1992 | — |
| Super Bomberman | Super Nintendo Entertainment System | 1993 | Hudson Soft |
| Super Bomberman 2 | Super Nintendo Entertainment System | 1994 | Hudson Soft |
| Super Bomberman 3 | Super Nintendo Entertainment System | 1995 | Hudson Soft |
| Super Bomberman 4 | Super Nintendo Entertainment System | 1996 | Produce! |
| Super Bomberman 5 | Super Nintendo Entertainment System | 1997 | Hudson Soft |
| Super Bomberman: Panic Bomber W | Super Nintendo Entertainment System | 1995 | — |
| Super Bombliss | Super Nintendo Entertainment System, Game Boy | 1995 | — |
| Super Bonk | Super Nintendo Entertainment System | 1994 | Red Entertainment |
| Super Bowling | Super Nintendo Entertainment System | 1992 | KID |
| Super Bubble Pop | Nintendo GameCube | 2002 | Zombie Studios |
| Super Buster Bros. | Super Nintendo Entertainment System | 1990 | Capcom |
| Super Caesars Palace | Super Nintendo Entertainment System | 1993 | Majesco Entertainment |
| Super Cars | Nintendo Entertainment System | 1990 | Gremlin Interactive |
| Super Casino 2 | Super Nintendo Entertainment System | 1994 | — |
| Super Castlevania IV | Super Nintendo Entertainment System | 1991 | Konami |
| Super Chase H.Q. | Super Nintendo Entertainment System | 1992 | Taito |
| Super Chinese 3 | Nintendo Entertainment System | 1991 | Culture Brain |
| Super Chinese Fighter | Super Nintendo Entertainment System | 1995 | Culture Brain |
| Super Chinese Fighter GB | Game Boy | 1996 | Culture Brain |
| Super Chinese Land 1-2-3 Dash | Game Boy | 1995 | Culture Brain |
| Super Chinese Land 3 | Game Boy | 1995 | Culture Brain |
| Super Chinese World 2 | Super Nintendo Entertainment System | 1993 | Culture Brain |
| Super Chinese World 3 | Super Nintendo Entertainment System | 1995 | Culture Brain |
| Super Conflict | Super Nintendo Entertainment System | 1993 | EA Seattle |
| Super Contra | Nintendo Entertainment System | 1988 | Konami |
| Super Dany | Super Nintendo Entertainment System | 1995 | Cryo Interactive |
| Super Dimension Fortress Macross: Scrambled Valkyrie | Super Nintendo Entertainment System | 1993 | Winkysoft |
| Super Dodge Ball | Nintendo Entertainment System | 1988 | Technōs Japan |
| Super Double Dragon | Super Nintendo Entertainment System | 1992 | Technōs Japan |
| Super Drift Out: World Rally Championships | Super Nintendo Entertainment System | 1995 | — |
| Super Dropzone | Super Nintendo Entertainment System | 1994 | — |
| Super F-1 Hero | Super Nintendo Entertainment System | 1992 | Varie |
| Super F1 Circus | Super Nintendo Entertainment System | 1992 | — |
| Super Famicom Wars | Super Nintendo Entertainment System, Wii | 1998 | Intelligent Systems |
| Super Family Gerende | Super Nintendo Entertainment System | 1998 | — |
| Super Famista 2 | Super Nintendo Entertainment System | 1993 | — |