| D-Force | Super Nintendo Entertainment System | 1991 | Asmik Ace Entertainment |
| D-Pad Hero | Nintendo Entertainment System | 2009 | Destructoid |
| Daedalian Opus | Game Boy | 1990 | Tokai Communications |
| Daffy Duck | Game Boy | 1994 | Sunsoft |
| Daffy Duck: The Marvin Missions | Super Nintendo Entertainment System | 1994 | ICOM Simulations |
| Daibakushou!! Jinsei Gekijou | Super Nintendo Entertainment System | 1992 | — |
| Daibakushou!! Jinsei Gekijou: Dokidoki Seishun Hen | Super Nintendo Entertainment System | 1993 | — |
| Daibakushou!! Jinsei Gekijou: Ooedo Nikki | Super Nintendo Entertainment System | 1994 | — |
| Daibakushou!! Jinsei Gekijou: Zukkoke Salaryman Hen | Super Nintendo Entertainment System | 1995 | — |
| Daikaijuu Battle: Ultra Coliseum | Wii | 2008 | Bandai Namco Entertainment |
| Daikaijū Monogatari | Super Nintendo Entertainment System | 1994 | Birthday |
| Daikaijū Monogatari II | Super Nintendo Entertainment System | 1996 | Birthday |
| Daisenryaku | Nintendo Entertainment System | 1988 | Quest |
| Daisenryaku | Super Nintendo Entertainment System | 1991 | Sega, Genki, SystemSoft Alpha |
| Daisy Fuentes Pilates | Wii | 2009 | Collision Studios |
| Daiva Story 6: Imperial of Nirsartia | Nintendo Entertainment System | 1986 | D Wonderland Inc. |
| Dakar 2: The World's Ultimate Rally | Nintendo GameCube | 2003 | Acclaim Studios London |
| Danball Senki Wars | Nintendo 3DS | 2013 | Level-5 |
| Dance Aerobics | Nintendo Entertainment System | 1987 | Human Entertainment |
| Dance Dance Revolution | Wii | 2010 | Konami |
| Dance Dance Revolution Disney Grooves | Wii | 2009 | Konami |
| Dance Dance Revolution Hottest Party | Wii | 2007 | Konami |
| Dance Dance Revolution Hottest Party 2 | Wii | 2008 | Konami |
| Dance Dance Revolution Hottest Party 3 | Wii | 2009 | Konami |
| Dance Dance Revolution II | Wii | 2011 | Konami |
| Dance Dance Revolution Winx Club | Wii | 2009 | Konami |
| Dance Dance Revolution: Mario Mix | Nintendo GameCube | 2005 | Konami |
| Dance on Broadway | Wii | 2010 | Ubisoft Halifax |
| Dance Sensation! | Wii | 2010 | Alpine Studios |
| Dance! It's Your Stage | Wii | 2010 | Sproing Interactive Media |
| Dancing with the Stars | Wii | 2007 | Zoë Mode |
| Dancing with the Stars: We Dance! | Wii | 2008 | Zoë Mode |
| Dangan GB2 | Game Boy | 2023 | — |
| Dangeresque 3: The Criminal Projective | Wii | 2008 | Telltale Games |
| Dangerous Road | Nintendo 3DS | 2023 | — |
| Danny Sullivan's Indy Heat | Nintendo Entertainment System | 1991 | Leland Corporation |
| Darius | Game Boy | 1987 | Taito |
| Darius Force | Super Nintendo Entertainment System | 1993 | Taito |
| Darius Twin | Super Nintendo Entertainment System | 1991 | Taito |
| Dark Half | Super Nintendo Entertainment System | 1996 | — |
| Dark Kingdom | Super Nintendo Entertainment System | 1994 | — |
| Dark Law: Meaning of Death | Super Nintendo Entertainment System | 1997 | — |
| Dark Lord | Nintendo Entertainment System | 1991 | Data East |
| Dark Summit | Nintendo GameCube | 2001 | Radical Entertainment |
| Darkened Skye | Nintendo GameCube | 2002 | Simon & Schuster, Boston Animation |
| Darkman | Nintendo Entertainment System | 1991 | Painting by Numbers, Ltd. |
| Darkman | Game Boy | 1991 | Ocean Software, Twilight |
| Darkwing Duck | Nintendo Entertainment System, Game Boy | 1992 | Capcom |
| Darts Up 3D | Nintendo 3DS | 2013 | EnjoyUp |
| Dash Galaxy in the Alien Asylum | Nintendo Entertainment System | 1990 | Krome Studios Melbourne |
| Dasshutsu Adventure: Noroi no Sūretsu | Nintendo 3DS | 2015 | Intense Limited |
| Dastardly and Muttley | Game Boy | 1992 | — |
| Data East Arcade Classics | Wii | 2010 | G1M2 |
| Datach | Nintendo Entertainment System | 1992 | Bandai |
| Date Kimiko no Virtual Tennis | Super Nintendo Entertainment System | 1994 | Jorudan |
| Dave Mirra BMX Challenge | Wii | 2006 | Left Field Productions |
| Dave Mirra Freestyle BMX 2 | Nintendo GameCube | 2001 | Underground Development |
| David Crane's Amazing Tennis | Super Nintendo Entertainment System | 1992 | Absolute Entertainment |
| Day Dreamin' Davey | Nintendo Entertainment System | 1992 | Sculptured Software |
| Days of Thunder | Nintendo Entertainment System, Game Boy | 1990 | Krome Studios Melbourne, Argonaut Games, Creative Materials, Tiertex Design Studios |
| Daze Before Christmas | Super Nintendo Entertainment System | 1994 | Funcom |
| De Blob | Wii | 2006 | THQ Nordic, Universomo, Ronimo Games, Blue Tongue Entertainment |
| De Blob 2 | Wii | 2011 | Blue Tongue Entertainment |
| Dead Heat Scramble | Game Boy | 1990 | — |
| Dead Names | Game Boy | 2024 | — |
| Dead or Alive: Dimensions | Nintendo 3DS | 2011 | Team Ninja |
| Dead Rising | Wii | 2006 | Capcom |
| Dead Rising: Chop Till You Drop | Wii | 2009 | Tose Co. |
| Dead Space: Extraction | Wii | 2009 | Visceral Games |
| Dead to Rights | Nintendo GameCube | 2002 | Namco |
| Deadeus | Game Boy | 2019 | — |
| Deadliest Catch: Sea of Chaos | Wii | 2010 | Crave Entertainment |
| Deadly Creatures | Wii | 2009 | THQ |
| Deadly Towers | Nintendo Entertainment System | 1986 | Lenar |
| Deal or No Deal | Wii | 2006 | Cat Daddy Games, Imagination Games, Black Lantern Studios, Inc., Vimukti Technologies |
| Deal or No Deal: Special Edition | Wii | 2010 | Mad Monkey Studio |
| Death Jr. II: Root of Evil | Wii | 2006 | Backbone Entertainment |
| Death Race | Nintendo Entertainment System | 1990 | — |
| Deathbots | Nintendo Entertainment System | 1990 | Odyssey Software |
| Deca Sports | Wii | 2008 | Hudson Soft |
| Deca Sports 2 | Wii | 2009 | Hudson Soft |
| Deca Sports 3 | Wii | 2010 | Hudson Soft |
| Deca Sports Extreme | Nintendo 3DS | 2011 | Hudson Soft |
| Decathlon | Nintendo Entertainment System | 1992 | C&E |
| Dedede's Drum Dash Deluxe | Nintendo 3DS | 2014 | HAL Laboratory |
| Deep Dungeon III: Yūshi e no Tabi | Nintendo Entertainment System | 1988 | Hummingbird Soft |
| Deep Dungeon IV: Kuro no Yōjutsushi | Nintendo Entertainment System | 1990 | Hummingbird Soft |
| Deer Drive Legends | Nintendo 3DS, Wii | 2012 | Raylight Games |
| Deer hunting king | Nintendo 3DS | 2013 | Arc System Works |
| Def Jam Rapstar | Wii | 2010 | 4mm Games |
| Def Jam Vendetta | Nintendo GameCube | 2003 | Syn Sophia |
| Def Jam: Fight for NY | Nintendo GameCube | 2004 | Syn Sophia |
| Defend Your Castle | Wii | 2008 | XGen Studios |
| Defender | Nintendo GameCube | 1981 | WMS Industries |
| Defender | Nintendo GameCube | 2002 | WMS Industries |
| Defender of the Crown | Nintendo Entertainment System | 1986 | Cinemaware |
| Defenders of Dynatron City | Nintendo Entertainment System | 1992 | Lucasfilm Games |
| Defenders of Law, Inc.: Crime in Willburg | Wii | — | Gameinvest, S.A. |
| Defendin' de Penguin | Wii | 2008 | Hijinx Studios, Brain Toys |
| Dekitate High School | Super Nintendo Entertainment System | 1995 | — |
| Dementium Remastered | Nintendo 3DS | 2015 | — |
| Demolition Man | Super Nintendo Entertainment System | 1994 | Virgin Interactive, Acclaim Entertainment |
| Demon Sword | Nintendo Entertainment System | 1988 | Tose Co. |
| Demon's Crest | Super Nintendo Entertainment System | 1994 | Capcom |
| Denjinmakai | Super Nintendo Entertainment System | 1993 | Winkysoft |
| Dennis the Menace | Super Nintendo Entertainment System | 1993 | Ocean Software |
| Desert Commander | Nintendo Entertainment System | 1988 | Kemco |
| Desert Strike | Super Nintendo Entertainment System, Game Boy | 1992 | Electronic Arts |
| Despicable Me: The Game | Wii | 2010 | Vicious Cycle Software |
| Destination Earthstar | Nintendo Entertainment System | 1990 | Imagineering |
| Destiny of an Emperor | Nintendo Entertainment System | 1989 | Capcom |
| Destroy All Humans! Big Willy Unleashed | Wii | 2008 | Locomotive Games |
| Detective Conan: Marionette Symphony | Nintendo 3DS | 2013 | Spike Chunsoft |
| Detective Conan: Phantom Rhapsody | Nintendo 3DS | 2014 | Spike Chunsoft |
| Detective Conan: The Suspicious Gorgeous Train | Game Boy | 1998 | Tom Create |
| Detective Pikachu | Nintendo 3DS | 2018 | Creatures |
| Devil Summoner: Soul Hackers | Nintendo 3DS | 1997 | Atlus |
| Devil World | Nintendo Entertainment System | 1984 | Nintendo |
| Dewy's Adventure | Wii | 2007 | Konami |
| Dexterity | Game Boy | 1990 | SNK |
| Dezaemon | Nintendo Entertainment System | 1991 | Athena |
| Dian Shi Mali | Nintendo Entertainment System | 1989 | — |
| Diatomic | Wii | 2009 | Grendel Games |
| Dick Tracy | Nintendo Entertainment System, Game Boy | 1990 | Realtime Associates |
| Die Hard | Nintendo Entertainment System | 1991 | Pack-In-Video |
| Die Hard: Vendetta | Nintendo GameCube | 2002 | Bits Studios |
| Dig & Spike Volleyball | Super Nintendo Entertainment System | 1992 | Tose Co. |
| Dig Dug | Nintendo Entertainment System, Game Boy | 1982 | Namco |
| Dig Dug II | Nintendo Entertainment System | 1985 | Namco |
| Digger T. Rock | Nintendo Entertainment System | 1990 | Rare Ltd. |
| Digimon Rumble Arena 2 | Nintendo GameCube | 2004 | Bandai Namco Entertainment |
| Digimon Universe: Appli Monsters | Nintendo 3DS | 2016 | Inti Creates |
| Digimon World 4 | Nintendo GameCube | 2005 | Bandai |
| Digimon World Re:Digitize Decode | Nintendo 3DS | 2013 | tri-Crescendo |
| Digital Devil Story: Megami Tensei | Nintendo Entertainment System | 1987 | Atlus |
| Digital Devil Story: Megami Tensei II | Nintendo Entertainment System | 1990 | Atlus |
| Dillon's Dead-Heat Breakers | Nintendo 3DS | 2018 | — |
| Dillon's Rolling Western | Nintendo 3DS | 2012 | Vanpool |
| Dillon's Rolling Western: The Last Ranger | Nintendo 3DS | 2013 | Vanpool |
| Diner Dash | Wii | 2003 | Gamelab |
| Diner Dash: Hometown Hero | Wii | 2007 | PlayFirst |
| Dino Breeder | Game Boy | 1997 | — |
| Dino Breeder 2 | Game Boy | 1998 | — |
| Dino Dini's Goal | Super Nintendo Entertainment System | 1993 | Dino Dini |
| Dino Dini's Soccer | Super Nintendo Entertainment System | 1994 | Dino Dini |
| Dino Strike | Wii | 2011 | N-Fusion Interactive |
| DinoCity | Super Nintendo Entertainment System | 1992 | Irem |
| Dinotopia: The Sunstone Odyssey | Nintendo GameCube | 2003 | Vicious Cycle Software |
| Dirt Trax FX | Super Nintendo Entertainment System | 1995 | Sculptured Software |
| Dirty Harry | Nintendo Entertainment System | 1990 | Mindscape |
| Dirty Racing | Game Boy | 1993 | Gremlin Interactive |
| Disaster: Day of Crisis | Wii | 2008 | Monolith Soft Inc. |
| Disney Art Academy | Nintendo 3DS | 2016 | Headstrong Games |
| Disney Channel All Star Party | Wii | 2010 | Page 44 Studios |
| Disney Infinity | Wii | 2013 | Avalanche Software |
| Disney Magical World | Nintendo 3DS | 2013 | h.a.n.d. |
| Disney Magical World 2 | Nintendo 3DS | 2015 | h.a.n.d. |
| Disney Princess: Enchanted Journey | Wii | 2007 | Papaya Studio |
| Disney Princess: Enchanting Storybooks | Wii | 2011 | Page 44 Studios |
| Disney Sing It | Wii | 2008 | Zoë Mode |
| Disney Sing It! – High School Musical 3: Senior Year | Wii | 2008 | Zoë Mode |
| Disney Sing It: Family Hits | Wii | 2010 | Zoë Mode |
| Disney Sing It: Party Hits | Wii | 2010 | Zoë Mode |
| Disney Sing It: Pop Hits | Wii | 2009 | Zoë Mode |
| Disney Sports Basketball | Nintendo GameCube | 2002 | Konami |
| Disney Sports Football | Nintendo GameCube | 2002 | Konami |
| Disney Sports Skateboarding | Nintendo GameCube | 2002 | Konami |
| Disney Sports Soccer | Nintendo GameCube | 2002 | Konami |
| Disney Think Fast | Wii | 2008 | Magenta Software |
| Disney Universe | Wii | 2011 | Eurocom |
| Disney's Aladdin | Nintendo Entertainment System, Game Boy | 1993 | Virgin Interactive |
| Disney's Aladdin | Super Nintendo Entertainment System | 1993 | Capcom |
| Disney's Beauty and the Beast | Super Nintendo Entertainment System | 1994 | — |
| Disney's Chicken Little: Ace in Action | Wii | 2006 | Avalanche Software |
| Disney's Extreme Skate Adventure | Nintendo GameCube | 2003 | Toys for Bob |
| Disney's Hide and Sneak | Nintendo GameCube | 2003 | Capcom |
| Disney's Magical Mirror Starring Mickey Mouse | Nintendo GameCube | 2002 | Capcom |
| Disney's Magical Quest 3 Starring Mickey & Donald | Super Nintendo Entertainment System | 1995 | Capcom |
| Disney's Mulan | Game Boy | — | Tiertex Design Studios |
| Disney's Party | Nintendo GameCube | 2003 | Neverland |
| Disney's Pocahontas | Game Boy | 1996 | Tiertex Design Studios, Funcom |
| Disney's Tarzan: Untamed | Nintendo GameCube | 2001 | Disney Interactive Studios, Ubisoft Montreal |
| Diva Girls: Divas on Ice | Wii | 2009 | Arc System Works |
| Dive: The Medes Islands Secret | Wii | 2010 | Over the Top Games |
| Dizzy: Prince of the Yolkfolk | Nintendo Entertainment System | 1991 | Big Red Software |
| DJ Hero | Wii | 2009 | Ubisoft Leamington |
| DJ Hero 2 | Wii | 2010 | Ubisoft Leamington |
| Do I Pass | Game Boy | 2019 | Taylor McCue |
| Doc Louis's Punch-Out!! | Wii | 2009 | Next Level Games |
| Doctor Lautrec and the Forgotten Knights | Nintendo 3DS | 2011 | Konami |
| Doctor Who: Return to Earth | Wii | 2010 | Asylum Entertainment |
| Dodge Racing: Charger vs. Challenger | Nintendo 3DS, Wii | 2009 | Extra Mile Studios |
| Dokapon DX: Wataru Sekai wa Oni Darake | Nintendo GameCube | 2003 | Asmik Ace Entertainment |
| Dokapon Kingdom | Wii | 2007 | Sting |
| Doki! Doki! Yūenchi: Crazy Land Daisakusen | Nintendo Entertainment System | 1991 | KID |
| Doll Fashion Atelier | Nintendo 3DS | — | Studio Mebius |
| Dolucky no Kusayakiu | Super Nintendo Entertainment System | 1993 | Zoom |
| Dolucky no Puzzle Tour '94 | Super Nintendo Entertainment System | 1994 | Zoom |
| Dolucky's A-League Soccer | Super Nintendo Entertainment System | 1994 | Zoom |
| Don Doko Don | Nintendo Entertainment System | 1989 | Taito |
| Don Doko Don 2 | Nintendo Entertainment System | 1992 | Taito |
| Don King Boxing | Wii | 2009 | 2K China |
| Donald Duck: Goin' Quackers | Nintendo GameCube | 2000 | Ubisoft Montreal |
| Donald In the Magic Cap | Super Nintendo Entertainment System | 1995 | — |
| Donald Land | Nintendo Entertainment System | 1988 | Data East |
| Donkey Kong | Nintendo Entertainment System | 1981 | Nintendo Research & Development 1, Ikegami Tsushinki, Nintendo |
| Donkey Kong | Game Boy | 1994 | Nintendo Entertainment Analysis & Development |
| Donkey Kong 3 | Nintendo Entertainment System | 1984 | Nintendo |
| Donkey Kong Barrel Blast | Wii | 2007 | Paon DP |
| Donkey Kong Classics | Nintendo Entertainment System | 1988 | Nintendo Entertainment Analysis & Development, Nintendo |
| Donkey Kong Country | Super Nintendo Entertainment System, Wii | 1994 | Rare Ltd. |
| Donkey Kong Country 2: Diddy's Kong Quest | Super Nintendo Entertainment System | 1995 | Rare Ltd. |
| Donkey Kong Country 3: Dixie Kong's Double Trouble! | Super Nintendo Entertainment System | 1996 | Rare Ltd. |
| Donkey Kong Country Returns | Wii | 2010 | Retro Studios |
| Donkey Kong Country Returns 3D | Nintendo 3DS | 2013 | — |
| Donkey Kong Jr. | Nintendo Entertainment System | 1982 | Nintendo |
| Donkey Kong Jr. Math | Nintendo Entertainment System | 1983 | Nintendo Research & Development 2 |
| Donkey Kong Jungle Beat | Nintendo GameCube, Wii | 2004 | Nintendo Entertainment Analysis & Development |
| Donkey Kong Land | Game Boy | 1995 | Rare Ltd. |
| Donkey Kong Land 2 | Game Boy | 1996 | Rare Ltd. |
| Donkey Kong Land III | Game Boy | 1997 | Rare Ltd. |
| Donkey Konga | Nintendo GameCube | 2003 | Namco |
| Donkey Konga 2 | Nintendo GameCube | 2004 | Namco |
| Donkey Konga 3 | Nintendo GameCube | 2005 | Namco |
| Dood's Big Adventure | Wii | 2010 | Rainbow Studios |
| Doodle Jump | Nintendo 3DS | 2009 | Lima Sky |
| Doodle Jump Adventures | Nintendo 3DS | — | Smoking Gun Interactive |
| Dooly Bravo Land | Nintendo Entertainment System | 1992 | Daou Infosys |
| Doom | Super Nintendo Entertainment System | 1993 | Nerve Software, id Software |
| Doom Troopers: Mutant Chronicles | Super Nintendo Entertainment System | 1995 | — |
| Doomsday Warrior | Super Nintendo Entertainment System | 1992 | — |
| Door Door | Nintendo Entertainment System | 1983 | Koichi Nakamura |
| Dora the Explorer: Dora Saves the Crystal Kingdom | Wii | 2009 | High Voltage Software |
| Dora the Explorer: Dora Saves the Snow Princess | Wii | 2008 | High Voltage Software |
| Dora the Explorer: Dora's Big Birthday Adventure | Wii | 2010 | High Voltage Software |
| Dora the Explorer: Journey to the Purple Planet | Nintendo GameCube | 2005 | Monkey Bar Games |
| Doraemon | Nintendo Entertainment System | 1986 | Hudson Soft |
| Doraemon 2: Nobita no Toys Land Daibouken | Super Nintendo Entertainment System | 1993 | SAS Sakata |
| Doraemon 3 | Super Nintendo Entertainment System | 1994 | Fortyfive |
| Doraemon 4 | Super Nintendo Entertainment System | 1995 | Agenda |
| Doraemon Wii | Wii | 2007 | Eighting |
| Doraemon: Giga Zombie no Gyakushū | Nintendo Entertainment System | 1990 | Epoch Co. |
| Doraemon: Minna de Asobō! Minidorando | Nintendo GameCube | 2003 | Epoch Co. |
| Doraemon: Nobita and the Island of Miracles ~Animal Adventure~ | Nintendo 3DS | 2012 | — |
| Doraemon: Nobita to Yousei no Kuni | Super Nintendo Entertainment System | 1993 | — |
| DoReMi Fantasy | Super Nintendo Entertainment System | 1996 | Hudson Soft |
| Dorke and Ymp | Super Nintendo Entertainment System | 2015 | — |
| Doshin the Giant | Nintendo GameCube | 1999 | Param |
| Dossun! Ganseki Battle | Super Nintendo Entertainment System | 1994 | — |
| Double Breakout | Nintendo 3DS | 2016 | nuGAME |
| Double Dare | Nintendo Entertainment System | 1988 | Rare Ltd. |
| Double Dragon | Nintendo Entertainment System, Nintendo 3DS | 1987 | Technōs Japan |
| Double Dragon 3: The Rosetta Stone | Game Boy | 1990 | East Technology Corp. |
| Double Dragon II | Game Boy | 1990 | Technōs Japan |
| Double Dragon II: The Revenge | Nintendo Entertainment System, Wii | 1989 | Technōs Japan |
| Double Dragon III: The Sacred Stones | Nintendo Entertainment System | 1991 | Technōs Japan |
| Double Dragon V: The Shadow Falls | Super Nintendo Entertainment System | 1994 | Leland Interactive Media |
| Double Dribble | Nintendo Entertainment System | 1987 | Konami |
| Double Moon Densetsu | Nintendo Entertainment System | 1992 | Nippon Computer Systems |
| Double Strike | Nintendo Entertainment System | 1990 | — |
| Doubutsu Kisoutengai | Wii | 2008 | Success |
| Dough Boy | Nintendo Entertainment System | 1985 | Synapse Software |
| Down the World: Mervil's Ambition | Super Nintendo Entertainment System | 1994 | — |
| Downtown Nekketsu Baseball Monogatari | Super Nintendo Entertainment System | 1993 | — |
| Downtown Nekketsu March: Super-Awesome Field Day! | Nintendo Entertainment System | 1990 | Technōs Japan |
| Downtown Run | Nintendo GameCube | 2003 | Ubisoft |
| Downtown Special: Kunio-kun's Historical Period Drama! | Nintendo Entertainment System, Game Boy, Nintendo 3DS | 1991 | Technōs Japan |
| Dr. Chaos | Nintendo Entertainment System | 1987 | Pony Canyon |
| Dr. Franken | Game Boy | 1992 | Motivetime Ltd. |
| Dr. Jekyll and Mr. Hyde | Nintendo Entertainment System | 1988 | Advance Communication |
| Dr. Mario | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1990 | Nintendo Research & Development 1 |
| Dr. Mario Online Rx | Wii | 2008 | Arika |
| Dr. Mario: Miracle Cure | Nintendo 3DS | 2015 | Arika |
| Dr. Muto | Nintendo GameCube | 2002 | Midway Games |
| Dr. Robotnik's Mean Bean Machine | Wii | 1993 | Sonic Team |
| Drac's Night Out | Nintendo Entertainment System | 1991 | — |
| Dracula: Undead Awakening | Wii | 2009 | Moregames Entertainment |
| Dragon Ball 3: Gokūden | Nintendo Entertainment System | 1989 | Tose Co. |
| Dragon Ball Fusions | Nintendo 3DS | 2016 | Ganbarion |
| Dragon Ball Z III: Ressen Jinzou Ningen | Nintendo Entertainment System | 1992 | Tose Co. |
| Dragon Ball Z Side Story: Plan to Eradicate the Saiyans | Nintendo Entertainment System | 1993 | Tose Co. |
| Dragon Ball Z: Budokai | Nintendo GameCube | 2002 | Dimps |
| Dragon Ball Z: Budokai 2 | Nintendo GameCube | 2003 | Dimps |
| Dragon Ball Z: Budokai Tenkaichi 3 | Wii | 2007 | Spike |
| Dragon Ball Z: Extreme Butōden | Nintendo 3DS | 2015 | Arc System Works |
| Dragon Ball Z: Hyper Dimension | Super Nintendo Entertainment System | 1996 | Bandai |
| Dragon Ball Z: Sagas | Nintendo GameCube | 2005 | Avalanche Software |
| Dragon Ball Z: Super Butōden | Super Nintendo Entertainment System | 1993 | Bandai |
| Dragon Ball Z: Super Butōden 2 | Super Nintendo Entertainment System | 1993 | Bandai |
| Dragon Ball Z: Super Butōden 3 | Super Nintendo Entertainment System | 1994 | Bandai |
| Dragon Ball Z: Super Gokuden - Kakusei-Hen | Super Nintendo Entertainment System | 1995 | — |
| Dragon Ball Z: Super Gokuden - Totsugeki-Hen | Super Nintendo Entertainment System | 1995 | — |
| Dragon Ball Z: Super Saiya Densetsu | Super Nintendo Entertainment System | 1992 | Tose Co. |
| Dragon Ball: Daimaō fukkatsu | Nintendo Entertainment System | 1988 | Bandai |
| Dragon Ball: Revenge of King Piccolo | Wii | 2009 | Media.Vision |
| Dragon Blade: Wrath of Fire | Wii | 2007 | D3 Publisher |
| Dragon Buster | Nintendo Entertainment System | 1985 | Namco |
| Dragon Drive: D-Masters Shot | Nintendo GameCube | 2003 | Treasure |
| Dragon Fighter | Nintendo Entertainment System | 1990 | Winning Entertainment Group |
| Dragon Knight 4 | Super Nintendo Entertainment System | 1994 | ELF Corporation |
| Dragon Lapis | Nintendo 3DS | 2020 | Exe-Create |
| Dragon Power | Nintendo Entertainment System | 1986 | Bandai |
| Dragon Quest | Nintendo Entertainment System, Super Nintendo Entertainment System, Nintendo 3DS, Wii | 1986 | Chunsoft |
| Dragon Quest 25 Shuunen Kinen: Famicom & Super Famicom Dragon Quest I-II-III | Wii | 2011 | Square Enix |
| Dragon Quest 25 Shūnen Kinen Famicom & Super Famicom Dragon Quest I・II・III | Wii | 2011 | Square Enix |
| Dragon Quest II | Nintendo Entertainment System, Super Nintendo Entertainment System | 1987 | Chunsoft |
| Dragon Quest III | Nintendo Entertainment System, Super Nintendo Entertainment System | 1988 | Chunsoft |
| Dragon Quest IV | Nintendo Entertainment System | 1990 | Chunsoft |
| Dragon Quest Monsters: Joker 3 | Nintendo 3DS | 2016 | Tose Co. |
| Dragon Quest Swords | Wii | 2007 | Genius Sonority |
| Dragon Quest V | Super Nintendo Entertainment System | 1992 | Chunsoft |
| Dragon Quest VI | Super Nintendo Entertainment System | 1995 | Heartbeat |
| Dragon Quest VIII | Nintendo 3DS | 2004 | Level-5 |
| Dragon Quest X | Nintendo 3DS, Wii | 2012 | Square Enix, Yuji Horii |
| Dragon Quest XI | Nintendo 3DS | 2017 | Square Enix |
| Dragon Quest: Monster Battle Road | Wii | 2008 | Eighting |
| Dragon Saber | Wii | 1990 | Namco |
| Dragon Scroll | Nintendo Entertainment System | 1987 | Konami |
| Dragon Slayer | Game Boy | 1984 | Nihon Falcom |
| Dragon Slayer: The Legend of Heroes | Super Nintendo Entertainment System | 1989 | Nihon Falcom |
| Dragon Slayer: The Legend of Heroes II | Super Nintendo Entertainment System | 1992 | Nihon Falcom |
| Dragon Spirit: The New Legend | Nintendo Entertainment System | 1989 | Namco |
| Dragon Squadron: Danzarb | Super Nintendo Entertainment System | 1993 | — |
| Dragon View | Super Nintendo Entertainment System | 1994 | Atari |
| Dragon Wars | Nintendo Entertainment System, Apple II series | 1991 | Interplay Entertainment |
| Dragon's Earth | Super Nintendo Entertainment System | 1993 | Human Entertainment |
| Dragon's Lair | Super Nintendo Entertainment System | 1992 | — |
| Dragon's Lair | Nintendo Entertainment System | 1990 | Motivetime Ltd. |
| Dragon's Lair 3D: Return to the Lair | Nintendo GameCube | 2002 | Dragonstone Software |
| Dragon's Lair Trilogy | Wii | 2010 | Digital Leisure, Dimitrij |
| Dragon: The Bruce Lee Story | Super Nintendo Entertainment System | 1994 | Virgin Interactive |
| DragonHeart: Fire & Steel | Game Boy | 1996 | Funcom |
| Dragons of Flame | Nintendo Entertainment System | 1989 | U.S. Gold |
| DragonStrike | Nintendo Entertainment System | 1992 | Westwood Studios, Pony Canyon |
| Drakkhen | Super Nintendo Entertainment System | 1989 | Infogrames |
| Drawn to Life: The Next Chapter | Wii | 2009 | Planet Moon Studios |
| Dream Basketball: Dunk & Hoop | Super Nintendo Entertainment System | 1994 | — |
| Dream Dance & Cheer | Wii | 2009 | indiePub |
| Dream Master | Nintendo Entertainment System | 1992 | Birthday |
| Dream Pinball 3D | Wii | 2008 | TopWare Interactive |
| Dream Salon | Wii | 2009 | CyberPlanet Interactive |
| Dream Trigger 3D | Nintendo 3DS | 2011 | Art Co., Ltd |
| Dream TV | Super Nintendo Entertainment System | 1994 | — |
| DreamMix TV World Fighters | Nintendo GameCube | 2003 | Hudson Soft |
| Dreamworld Pogie | Nintendo Entertainment System | 2016 | Oliver Twins |
| Driift Mania | Wii | 2009 | Konami |
| Drill Sergeant Mindstrong | Wii | 2009 | Xseed Games |
| Driven | Nintendo GameCube | 2001 | BAM! Entertainment |
| Driver: Parallel Lines | Wii | 2006 | Ubisoft Reflections |
| Driver: Renegade | Nintendo 3DS | 2011 | Ubisoft |
| Driver: San Francisco | Wii | 2011 | Ubisoft Reflections |
| Drome Racers | Nintendo GameCube | 2002 | — |
| Drone Fight | Nintendo 3DS | 2016 | SilverStarJapan Co., Ltd. |
| Dropzone | Nintendo Entertainment System | 1984 | Archer Maclean |
| DSiWare | Nintendo 3DS | 2009 | Nintendo |
| DT: Lords of Genomes | Game Boy | 2001 | — |
| Dual Orb | Super Nintendo Entertainment System | 1993 | — |
| Dual Orb II | Super Nintendo Entertainment System | 1994 | Nippon Ichi Software |
| DualPenSports | Nintendo 3DS | 2011 | indieszero |
| Duck | Nintendo Entertainment System | 1987 | Bit Corporation |
| Duck Hunt | Nintendo Entertainment System | 1984 | Nintendo Research & Development 1 |
| DuckTales | Nintendo Entertainment System, Game Boy | 1989 | Capcom |
| DuckTales 2 | Nintendo Entertainment System, Game Boy | 1993 | Capcom |
| Duel Masters Nettou! Battle Arena | Nintendo GameCube | 2003 | Takara |
| Dungeon Kid | Nintendo Entertainment System | 1990 | Quest |
| Dungeon Land | Game Boy | 1992 | — |
| Dungeon Magic: Sword of the Elements | Nintendo Entertainment System | 1989 | Winning Entertainment Group |
| Dungeon Master | Super Nintendo Entertainment System, Apple II series | 1987 | FTL Games |
| Dungeon Savior | Game Boy | 2000 | — |
| Dusty Diamond's All-Star Softball | Nintendo Entertainment System | 1989 | Tose Co. |
| Dynamite Bowl | Nintendo Entertainment System | 1987 | Soft Vision International |
| DynamiTracer | Super Nintendo Entertainment System | 1996 | Square |
| Dynasty Warriors VS | Nintendo 3DS | 2012 | — |
| Dynowarz: Destruction of Spondylus | Nintendo Entertainment System | 1990 | Advance Communication |
| Déjà Vu | Nintendo Entertainment System | 1985 | ICOM Simulations |
| Dōkyūsei 2 | Super Nintendo Entertainment System | 1995 | ELF Corporation |