| U-Sing | Wii | 2009 | Mindscape |
| U.N. Squadron | Super Nintendo Entertainment System | 1991 | Capcom |
| U.S. Championship V'Ball | Nintendo Entertainment System | 1989 | Technōs Japan |
| Uchuu Race: Astro Go! Go! | Super Nintendo Entertainment System | 1994 | KAZe |
| Uchū no Kishi: Tekkaman Blade | Super Nintendo Entertainment System, Game Boy | 1993 | — |
| Uchūsen: Cosmo Carrier | Nintendo Entertainment System | 1987 | Tose Co. |
| UDraw Pictionary | Wii | 2010 | Page 44 Studios |
| UDraw Studio | Wii | 2010 | Pipeworks Software |
| UEFA Champions League 2004-2005 | Nintendo GameCube | 2005 | — |
| UFC Personal Trainer | Wii | 2011 | Heavy Iron Studios |
| UFC: Throwdown | Nintendo GameCube | 2002 | Genki |
| UFO Kamen Yakisoban | Super Nintendo Entertainment System | 1994 | KID |
| Ufouria: The Saga | Nintendo Entertainment System, Nintendo 3DS, Wii | 1991 | Sunsoft, City Connection |
| Ultima III: Exodus | Nintendo Entertainment System | 1983 | Richard Garriott |
| Ultima IV: Quest of the Avatar | Nintendo Entertainment System | 1985 | Origin Systems |
| Ultima V: Warriors of Destiny | Nintendo Entertainment System | 1988 | Origin Systems |
| Ultima VI: The False Prophet | Super Nintendo Entertainment System | 1990 | Origin Systems |
| Ultima VII: The Black Gate | Super Nintendo Entertainment System | 1992 | Origin Systems |
| Ultima: Runes of Virtue | Game Boy | 1991 | Origin Systems |
| Ultima: Runes of Virtue II | Super Nintendo Entertainment System, Game Boy | 1994 | Origin Systems |
| Ultimate Air Combat | Nintendo Entertainment System | 1992 | Activision |
| Ultimate Band | Wii | 2008 | Fall Line Studios |
| Ultimate Basketball | Nintendo Entertainment System | 1990 | Aicom |
| Ultimate Duck Hunting | Wii | 2006 | Mid Carolina Media |
| Ultimate Fighter | Super Nintendo Entertainment System | 1992 | Culture Brain |
| Ultimate I Spy | Wii | 2008 | Gusto Games |
| Ultimate Mortal Kombat 3 | Super Nintendo Entertainment System, Game Boy | 1996 | Midway Games |
| Ultimate Muscle: Legends vs. New Generation | Nintendo GameCube | 2002 | Syn Sophia |
| Ultimate NES Remix | Nintendo 3DS | 2014 | — |
| Ultimate Shooting Collection | Wii | 2008 | Milestone |
| Ultimate Spider-Man | Nintendo GameCube | 2005 | Blizzard Albany, Treyarch, Beenox |
| Ultra Baseball Jitsumeiban | Super Nintendo Entertainment System | 1992 | — |
| Ultra Coliseum DX: Ultra Senshi Daishuketsu | Wii | 2010 | Bandai Namco Entertainment |
| Ultra Golf | Game Boy | 1991 | Ultra Games |
| Ultra Hand for Wii | Wii | 2010 | Nintendo |
| Ultra League | Super Nintendo Entertainment System | 1995 | — |
| Ultra Seven | Super Nintendo Entertainment System | 1993 | Bandai |
| Ultraman: Towards the Future | Super Nintendo Entertainment System | 1991 | — |
| Umi no Nushi Tsuri | Super Nintendo Entertainment System | 1996 | — |
| Unchained Blades | Nintendo 3DS | 2011 | Furyu Corporation |
| Unchained Blades Exiv | Nintendo 3DS | 2012 | Furyu Corporation |
| Uncharted Waters | Nintendo Entertainment System, Super Nintendo Entertainment System | 1990 | Koei |
| Uncharted Waters II: New Horizons | Super Nintendo Entertainment System | 1994 | Koei |
| Undead Bowling | Nintendo 3DS | 2013 | — |
| Undercover Cops | Super Nintendo Entertainment System | 1995 | Irem |
| Undercover Cops: Hakaishin Garumaa | Game Boy | 1993 | Irem |
| Unholy Night: The Darkness Hunter | Super Nintendo Entertainment System | 2017 | — |
| Uninvited | Nintendo Entertainment System | 1986 | ICOM Simulations |
| Uniracers | Super Nintendo Entertainment System | 1994 | Rockstar North |
| Unity | Nintendo GameCube | 2004 | Jeff Minter |
| Universal Soldier | Game Boy | 1992 | The Code Monkeys |
| Universal Studios Theme Parks Adventure | Nintendo GameCube | 2001 | Kemco |
| Up | Wii | 2009 | Heavy Iron Studios |
| Urban Champion | Nintendo Entertainment System | 1984 | Nintendo Research & Development 1 |
| Urban Extreme: Street Rage | Wii | 2008 | Data Design Interactive |
| Urban Strike | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Urban Trial Freestyle | PlayStation Vita, Nintendo 3DS | 2013 | Tate Multimedia |
| Urbanix | Wii | 2011 | Nordcurrent |
| Ushio to Tora: Shin'en no Daiyō | Nintendo Entertainment System | 1993 | Pixel |
| Utopia: The Creation of a Nation | Super Nintendo Entertainment System | 1991 | — |
| Utsurun Desu.: Kawauso Hawaii e Iku!!! | Nintendo Entertainment System | 1992 | Tomy |