| E-Motion | Game Boy | 1990 | The Assembly Line |
| E.V.O.: Search for Eden | Super Nintendo Entertainment System | 1992 | Givro |
| EA Playground | Wii | 2007 | EA Vancouver |
| EA Sports Active | Wii | 2009 | EA Vancouver |
| EA Sports Active 2 | Wii | 2010 | EA Vancouver |
| EA Sports Active NFL Training Camp | Wii | 2010 | EA Vancouver |
| EA Sports Active: More Workouts | Wii | 2009 | Jędrzej Kitowicz |
| Earth Defense Force | Super Nintendo Entertainment System | 1991 | Jaleco |
| Earth Light | Super Nintendo Entertainment System | 1992 | Hudson Soft |
| EARTH LIGHT LUNA STRIKE | Super Nintendo Entertainment System | 1996 | — |
| Earth Seeker | Wii | 2011 | Crafts & Meister |
| EarthBound | Super Nintendo Entertainment System | 1994 | HAL Laboratory, Creatures |
| EarthBound 64 | Super Nintendo Entertainment System | 2000 | Nintendo |
| EarthBound Halloween Hack | Super Nintendo Entertainment System | 2008 | — |
| Earthworm Jim | Super Nintendo Entertainment System, Game Boy | 1994 | Shiny Entertainment |
| Earthworm Jim 2 | Super Nintendo Entertainment System | 1995 | Shiny Entertainment |
| Earthworm Jim: Menace 2 the Galaxy | Game Boy | 1999 | — |
| Eastward: Octopia | Nintendo 3DS | 2024 | Pixpil |
| Eco Shooter: Plant 530 | Wii | 2009 | Intelligent Systems |
| Ed, Edd n Eddy: The Mis-Edventures | Nintendo GameCube | 2005 | Behaviour Interactive |
| Edo no Kiba | Super Nintendo Entertainment System | 1993 | Riot |
| Eduardo the Samurai Toaster | Wii | 2009 | Semnat Studios |
| Eek! The Cat | Super Nintendo Entertainment System | 1994 | — |
| Egg Mania: Eggstreme Madness | Nintendo GameCube | 2002 | HotGen |
| Eggerland – Revival of the Labyrinth | Nintendo Entertainment System | 1988 | HAL Laboratory |
| Egypt | Nintendo Entertainment System | 1991 | Human Entertainment |
| Eisei Meijin VI | Nintendo GameCube | 2002 | Konami |
| El Chavo | Wii | 2012 | Kaxan Games |
| Elebits | Wii | 2006 | Konami |
| Elevator Action | Nintendo Entertainment System, Game Boy | 1983 | Taito |
| Elfaria | Super Nintendo Entertainment System | 1993 | Hudson Soft, Red Entertainment |
| Elfaria II: The Quest of the Meld | Super Nintendo Entertainment System | 1995 | — |
| Eliminator Boat Duel | Nintendo Entertainment System | 1991 | Sculptured Software |
| Elite | Nintendo Entertainment System | 1984 | David Braben, Ian Bell |
| Elite Soccer | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Elite Soccer | Game Boy | 1994 | — |
| Elminage Original | Nintendo 3DS | 2012 | — |
| Emerald Dragon | Super Nintendo Entertainment System | 1995 | Alfa System |
| Emeraldia | Wii | 1993 | Namco |
| Emergency Heroes | Wii | 2008 | Ubisoft Reflections |
| Emergency Mayhem | Wii | 2008 | Supersonic Software |
| Emit | Super Nintendo Entertainment System | 1994 | Koei |
| Emmitt Smith Football | Super Nintendo Entertainment System | 1995 | — |
| Empire City: 1931 | Nintendo Entertainment System | 1987 | Seibu Kaihatsu |
| Endless Ocean | Wii | 2007 | Arika |
| Endless Ocean 2: Adventures of the Deep | Wii | 2009 | Arika |
| Energy Breaker | Super Nintendo Entertainment System | 1996 | Neverland |
| Ennichi no Tatsujin | Wii | 2006 | Bandai Namco Holdings |
| Enter the Matrix | Nintendo GameCube | 2003 | Shiny Entertainment |
| Epic Mickey | Wii | 2010 | Junction Point Studios |
| Epic Mickey 2: The Power of Two | PlayStation Vita, Wii | 2012 | Junction Point Studios, Blitz Games Studios, Heavy Iron Studios |
| Epic Mickey: Power of Illusion | Nintendo 3DS | 2012 | DreamRift |
| Equilibrio | Wii | 2009 | DK-Games, Fishing Cactus |
| Equinox | Super Nintendo Entertainment System | 1993 | Software Creations |
| Erika to Satoru no Yume Bōken | Nintendo Entertainment System | 1988 | Atlus |
| Erunaaku no Zaihou | Nintendo Entertainment System | 1987 | Towa Chiki |
| Escape from Bug Island | Wii | 2006 | Spike |
| EscapeVektor | PlayStation Vita, Nintendo 3DS, Wii | 2011 | Nnooo |
| Esper Boukentai: Maou no Toride | Nintendo Entertainment System | 1987 | NMK |
| Esper Dream | Nintendo Entertainment System, Nintendo 3DS, Wii | 1987 | Konami |
| ESPN Baseball Tonight | Super Nintendo Entertainment System | 1994 | Park Place Productions |
| ESPN International Winter Sports 2002 | Nintendo GameCube | 2002 | Konami |
| ESPN MLS ExtraTime 2002 | Nintendo GameCube | 2001 | Konami |
| ESPN National Hockey Night | Super Nintendo Entertainment System | 1994 | Sony Imagesoft |
| ESPN SpeedWorld | Super Nintendo Entertainment System | 1994 | Park Place Productions |
| ESPN Sunday Night NFL | Super Nintendo Entertainment System | 1994 | Absolute Entertainment |
| ESWAT: City Under Siege | Wii | 1990 | Sega |
| Eternal Darkness: Sanity's Requiem | Nintendo GameCube | 2002 | Silicon Knights |
| Eternal Filena | Super Nintendo Entertainment System | 1995 | Tokuma Shoten |
| Eternity's Child | Wii | 2008 | SilverSphereStudios, Luc Bernard |
| Etrian Mystery Dungeon | Nintendo 3DS | 2015 | Spike Chunsoft, Atlus |
| Etrian Mystery Dungeon 2 | Nintendo 3DS | 2017 | Spike Chunsoft |
| Etrian Odyssey 2 Untold: The Fafnir Knight | Nintendo 3DS | 2014 | — |
| Etrian Odyssey IV | Nintendo 3DS | 2012 | Atlus |
| Etrian Odyssey Nexus | Nintendo 3DS | 2018 | Atlus |
| Etrian Odyssey Untold: The Millennium Girl | Nintendo 3DS | 2013 | Atlus |
| Etrian Odyssey V | Nintendo 3DS | 2016 | Atlus |
| Evasive Space | Wii | 2009 | High Voltage Software |
| Ever Oasis | Nintendo 3DS | 2017 | Grezzo |
| Everybody Votes Channel | Wii | 2007 | Nintendo |
| Everyone Sing | Wii | 2012 | Gusto Games |
| Evolution Skateboarding | Nintendo GameCube | 2002 | Konami |
| Evolution Snowboarding | Nintendo GameCube | 2002 | Konami |
| Evolution Worlds | Nintendo GameCube | 2002 | Sting |
| Excite Truck | Wii | 2006 | Monster Games |
| Excitebike | Nintendo Entertainment System, Wii | 1984 | Nintendo Research & Development 1 |
| Excitebike: World Rally | Wii | 2009 | Monster Games |
| ExciteBots: Trick Racing | Wii | 2009 | Monster Games |
| Exciting Boxing | Nintendo Entertainment System | 1987 | Human Entertainment |
| ExerBeat | Wii | 2011 | Bandai Namco Entertainment |
| Exerion | Nintendo Entertainment System | 1983 | Tose Co., Gotch Technology Corp. |
| Exodus | Nintendo Entertainment System | 1991 | Color Dreams |
| Exstetra | PlayStation Vita, Nintendo 3DS | 2013 | Studio Saizensen |
| Extra Innings | Super Nintendo Entertainment System | 1991 | Sting |
| Extreme-G 3 | Nintendo GameCube | 2001 | Acclaim Studios London |
| ExZeus | Wii | 2007 | HyperDevbox Japan |
| Eye of the Beholder | Super Nintendo Entertainment System | 1990 | Strategic Simulations, Westwood Studios |
| Eyeshield 21: Field Saikyō no Senshi Tachi | Wii | 2007 | Hiroki Tsurumoto |