| Rally Championship | Nintendo GameCube | 2002 | Warthog Games |
| Rambo | Nintendo Entertainment System | 1987 | Pack-In-Video |
| Rampage | Nintendo Entertainment System, Wii | 1986 | Midway Games |
| Rampage: Total Destruction | Nintendo GameCube, Wii | 2006 | Pipeworks Software |
| Rampart | Nintendo Entertainment System, Super Nintendo Entertainment System | 1990 | Atari Games |
| Rango | Wii | 2011 | Behaviour Interactive |
| Ranma ½ | Game Boy | 1990 | Banpresto |
| Ranma ½: Chougi Ranbu Hen | Super Nintendo Entertainment System | 1994 | — |
| Ranma ½: Chōnai Gekitōhen | Super Nintendo Entertainment System | 1992 | Nippon Computer Systems |
| Ranma ½: Hard Battle | Super Nintendo Entertainment System | 1992 | Nippon Computer Systems |
| Ranma ½: Hidden Treasures of the Crimson Cats | Super Nintendo Entertainment System | 1993 | — |
| Rapala Fishing Frenzy 2009 | Wii | 2008 | Modus Studios Bucharest |
| Rapala Pro Bass Fishing | Wii | 2010 | Modus Studios Bucharest |
| Rapala Tournament Fishing | Wii | 2006 | Modus Studios Bucharest |
| Rapala: We Fish | Wii | 2009 | Polygon Magic |
| Rasāru Ishii no Childs Quest | Nintendo Entertainment System | 1989 | Namco |
| Ratatouille | Nintendo GameCube, Wii | 2007 | Asobo Studio |
| Ratatouille | Wii | 2007 | Asobo Studio |
| Ratatouille | Nintendo GameCube, Wii | 2007 | Heavy Iron Studios |
| Rats! | Game Boy | 1998 | — |
| Rave Master | Nintendo GameCube | 2002 | Konami |
| Raving Rabbids: Travel in Time | Wii | 2010 | Ubisoft Paris |
| Rayman | Nintendo 3DS | 1995 | Ubisoft Montpellier |
| Rayman 3: Hoodlum Havoc | Nintendo GameCube | 2003 | Ubisoft, Ubisoft Shanghai |
| Rayman M | Nintendo GameCube | 2001 | Ubisoft Montpellier |
| Rayman Origins | PlayStation Vita, Nintendo 3DS, Wii | 2011 | Ubisoft Montpellier |
| Rayman Raving Rabbids | Wii | 2006 | Ubisoft Montpellier |
| Rayman Raving Rabbids 2 | Nintendo 3DS, Wii | 2007 | Ubisoft |
| Rayman Raving Rabbids: TV Party | Wii | 2008 | Ubisoft Paris |
| Reader Rabbit Kindergarten: Bounce Down in Balloon Town! | Wii | 2001 | Graffiti Entertainment, The Learning Company |
| Reader Rabbit Preschool: Sparkle Star Rescue | Wii | 2001 | The Learning Company |
| Ready 2 Rumble: Revolution | Wii | 2009 | Syn Sophia |
| Ready Set Word | Wii | — | Ubisoft |
| Real Heroes: Firefighter | Wii | 2009 | Epicenter Studios |
| Realm | Super Nintendo Entertainment System | 1997 | Titus Interactive |
| Rebel Raiders: Operation Nighthawk | Wii | 2006 | Kando Games |
| Rec Room Games | Wii | 2009 | Arcade Moon |
| Recca | Nintendo Entertainment System | 1992 | KID |
| Record of Lodoss War | Super Nintendo Entertainment System | 1995 | — |
| Recruit Simulation: Shuushoku Game | Super Nintendo Entertainment System | 1995 | — |
| Red Faction II | Nintendo GameCube | 2002 | Volition |
| Red Steel | Wii | 2006 | Ubisoft Paris |
| Red Steel 2 | Wii | 2010 | Ubisoft |
| RedCard 2003 | Nintendo GameCube | 2002 | Point of View, Inc. |
| Reel Fishing Challenge | Wii | 2009 | Marvelous Entertainment |
| Reel Fishing Paradise 3D | Nintendo 3DS | 2011 | Winning Entertainment Group |
| Reel Fishing: Angler's Dream | Wii | 2009 | Marvelous Entertainment |
| Regular Show: Mordecai and Rigby in 8-Bit Land | Nintendo 3DS | 2013 | WayForward Technologies |
| Rei Fighter Gekitsui Senki | Nintendo GameCube | 2003 | Global A Entertainment |
| Reign of Fire | Nintendo GameCube | 2002 | Kuju Ltd. |
| Rejoice: Aretha Ōkoku no Kanata | Super Nintendo Entertainment System | 1995 | Japan Art Media |
| Relief Pitcher | Super Nintendo Entertainment System | 1992 | — |
| Reload | Wii | 2010 | Mastiff LLC |
| Remington Super Slam Hunting: Alaska | Wii | 2011 | eV Interactive |
| Remington Super Slam Hunting: North America | Wii | 2010 | Jack of All Games |
| Remington: Great American Bird Hunt | Wii | 2009 | Kouyousha |
| Remote Control | Nintendo Entertainment System | 1990 | RSP, Inc. |
| Rendering Ranger: R2 | Super Nintendo Entertainment System | 1995 | Rainbow Arts |
| Renegade | Nintendo Entertainment System | 1986 | Technōs Japan |
| Resident Evil | Nintendo GameCube, Wii | 2002 | Capcom |