| Q15875495 | Game Boy | 1992 | — |
| Q17211177 | Nintendo 3DS | 2013 | — |
| Q17211187 | Nintendo 3DS | 2014 | — |
| Q17214683 | Nintendo 3DS | 2013 | — |
| Q17214744 | Nintendo 3DS | 2013 | — |
| Q17220972 | Nintendo 3DS | 2013 | — |
| Q18339159 | Nintendo 3DS | — | SmileBoom |
| Q3835890 | Nintendo 3DS | 2011 | — |
| Q4474402 | Nintendo 3DS | 2013 | — |
| Q65228476 | Game Boy | 1994 | — |
| Q65261320 | Nintendo 3DS | 2016 | — |
| Q84763790 | Nintendo 3DS | 2015 | — |
| Q86699163 | Nintendo 3DS | 2012 | — |
| QBillion | Game Boy | 1989 | SETA Corporation |
| Qix | Nintendo Entertainment System, Game Boy | 1981 | Taito |
| Quarters, Please! | Nintendo 3DS | 2019 | Nostatic Software |
| Quarters, Please! Vol. 2 | Nintendo 3DS | 2020 | Nostatic Software |
| Quattro Adventure | Nintendo Entertainment System | 1993 | — |
| Quattro Sports | Nintendo Entertainment System | 1993 | — |
| Quell Memento | Nintendo 3DS | 2015 | — |
| Quell Reflect | Nintendo 3DS | 2011 | — |
| Quest of Dungeons | Nintendo 3DS | 2014 | — |
| Quiz Party | Wii | 2012 | Wizarbox |
| R-Type III: The Third Lightning | Super Nintendo Entertainment System, Wii | 1993 | Irem |
| R.B.I. Baseball | Nintendo Entertainment System | 1986 | Namco |
| R.B.I. Baseball 2 | Nintendo Entertainment System | 1987 | — |
| R.B.I. Baseball 3 | Super Nintendo Entertainment System | 1991 | — |
| R.C. Pro-Am | Nintendo Entertainment System | 1988 | Rare Ltd. |
| R.C. Pro-Am II | Nintendo Entertainment System | 1992 | Rare Ltd. |
| R: Racing Evolution | Nintendo GameCube | 2003 | Namco |
| Rabbids Go Home | Wii | 2009 | Ubisoft Montpellier |
| Rabbids Rumble | Nintendo 3DS | 2012 | Kuju Ltd. |
| Race America | Nintendo Entertainment System | 1990 | Imagineering |
| Race Days | Game Boy | 1994 | Gremlin Interactive |
| Race Drivin' | Super Nintendo Entertainment System | 1990 | Atari Games |
| Racer Mini Yonku: Japan Cup | Nintendo Entertainment System | 1989 | Konami |
| Racing Damashii | Game Boy | 1991 | Irem |
| Racing Simulation 3 | Nintendo GameCube | 2002 | Ubisoft |
| Racket Attack | Nintendo Entertainment System | 1988 | Tose Co. |
| Racket Sports Party | Wii | 2010 | Asobo Studio |
| Rackets & Rivals | Nintendo Entertainment System | 1993 | Konami |
| Racquet Sports | Wii | 2010 | Nir |
| Rad Racer | Nintendo Entertainment System | 1987 | Square |
| Radia Senki: Reimeihen | Nintendo Entertainment System | 1991 | Tecmo |
| Radiant Historia: Perfect Chronology | Nintendo 3DS | 2017 | — |
| Radical Dreamers | Super Nintendo Entertainment System | 1996 | Square |
| Radical Rex | Super Nintendo Entertainment System | 1994 | Krome Studios Melbourne, Piko Interactive |
| Radiohammer | PlayStation Vita, Nintendo 3DS | 2014 | — |
| Radirgy | Nintendo GameCube | 2005 | Milestone |
| Radirgy Noa | Wii | 2010 | Milestone |
| Rage of the Gladiator | Nintendo 3DS, Wii | 2010 | Ghostfire Games |
| Raging Fighter | Game Boy | 1993 | Konami |
| Raid 2020 | Nintendo Entertainment System | 1989 | Color Dreams |
| Raid on Bungeling Bay | Nintendo Entertainment System | 1984 | Aackosoft, Will Wright |
| Raiden | Super Nintendo Entertainment System | 1991 | Seibu Kaihatsu |
| Rainbow Islands: The Story of Bubble Bobble 2 | Nintendo Entertainment System | 1987 | Taito |
| Rainbow Islands: Towering Adventure! | Wii | 2009 | Taito |
| Rainbow Snake | Nintendo 3DS | 2017 | — |
| Raishi | PlayStation Vita, Nintendo 3DS | 2015 | — |
| Rally Bike | Nintendo Entertainment System | 1988 | Toaplan |