| Pro Yakyuu Famista Returns | Nintendo 3DS | 2015 | Bandai Namco Entertainment, Eighting |
| Pro Yakyū Family Stadium | Wii | 2008 | Bandai Namco Entertainment |
| Pro Yakyū Nettō: Puzzle Stadium | Super Nintendo Entertainment System | 1997 | — |
| Pro Yakyū Star | Super Nintendo Entertainment System | 1997 | Culture Brain |
| Professor Heinz Wolff's Gravity | Wii | 2008 | Deep Silver |
| Professor Layton and the Azran Legacy | Nintendo 3DS | 2013 | Level-5 |
| Professor Layton and the Miracle Mask | Nintendo 3DS | 2011 | Level-5 |
| Professor Layton vs. Ace Attorney | Nintendo 3DS | 2012 | Level-5 |
| Project Dream | Super Nintendo Entertainment System | 1998 | Rare Ltd. |
| Project H.A.M.M.E.R. | Wii | — | Nintendo Software Technology |
| Project Runway | Wii | 2010 | Tornado Studios |
| Project X Zone | Nintendo 3DS | 2012 | Banpresto |
| Project X Zone 2 | Nintendo 3DS | 2015 | Monolith Soft Inc., Banpresto |
| Project Zero 2: Wii Edition | Wii | 2012 | Koei Tecmo Holdings |
| Protöthea | Wii | 2005 | Digital Builders, Sabarasa Entertainment |
| Proun+ | Nintendo 3DS | 2015 | Engine Software |
| Psycho Dream | Super Nintendo Entertainment System | 1992 | Riot |
| Punch Club | Nintendo 3DS | 2016 | Lazy Bear Games |
| Punch-Out!! | Nintendo Entertainment System | 1987 | Nintendo development teams |
| Punch-Out!! | Wii | 2009 | Next Level Games |
| Puppy Luv | Wii | 2007 | Gogii Games |
| Purr Pals | Wii | 2007 | Crave Entertainment |
| Push-Over | Super Nintendo Entertainment System | 1992 | Red Rat Software |
| Pushmo | Nintendo 3DS | 2011 | Intelligent Systems |
| Puss 'n Boots: Pero's Great Adventure | Nintendo Entertainment System | 1990 | Shouei System |
| Puss in Boots | Wii | 2011 | Blitz Games |
| Putty | Super Nintendo Entertainment System | 1992 | System 3 |
| Putty Squad | Super Nintendo Entertainment System, PlayStation Vita | 1994 | System 3 |
| Puyo Pop Fever | Nintendo GameCube | 2004 | Sonic Team |
| Puyo Puyo | Nintendo Entertainment System, Super Nintendo Entertainment System | 1991 | Compile |
| Puyo Puyo 2 | Super Nintendo Entertainment System | 1994 | Compile |
| Puyo Puyo 7 | Wii | 2009 | Sonic Team |
| Puyo Puyo Chronicle | Nintendo 3DS | 2016 | Sonic Team |
| Puyo Puyo Tetris | PlayStation Vita, Nintendo 3DS | 2014 | Sonic Team |
| Puyo Puyo! 15th Anniversary | Wii | 2006 | Sonic Team |
| Puyo Puyo!! 20th Anniversary | Nintendo 3DS, Wii | 2011 | Sonic Team |
| Puzzle & Dragons Z | Nintendo 3DS | 2013 | GungHo Online Entertainment |
| Puzzle & Dragons Z + Super Mario Bros. Edition | Nintendo 3DS | 2015 | GungHo Online Entertainment |
| Puzzle & Dragons: Super Mario Bros. Edition | Nintendo 3DS | 2015 | GungHo Online Entertainment |
| Puzzle Balls | Wii | 2007 | System 3 |
| Puzzle Bobble | Super Nintendo Entertainment System | 1994 | Taito |
| Puzzle Bobble Plus! | Wii | 2009 | Taito |
| Puzzle Challenge: Crosswords and More | Wii | 2006 | Supersonic Software |
| Puzzle Kingdoms | Wii | 2009 | Infinity Plus Two |
| Puzzle Quest: Challenge of the Warlords | Wii | 2007 | 1st Playable Productions, Infinity Plus Two |
| Puzzle Series Vol. 2: Illust Logic + Colorful Logic | Wii | 2008 | Hudson Soft |
| Puzzle'N Desu! | Super Nintendo Entertainment System | 1995 | — |
| Puzznic | Nintendo Entertainment System | 1989 | Taito |
| Pyoro | Nintendo 3DS | 2003 | Intelligent Systems, Nintendo Software Planning & Development, Nintendo Research & Development 1 |
| Pyroblazer | Wii | 2008 | Eipix Entertainment |
| Q Boy | Nintendo Entertainment System | 1994 | — |
| Q*bert | Nintendo Entertainment System, Game Boy, PlayStation Vita | 1982 | Atari |
| Q*bert 3 | Super Nintendo Entertainment System | 1992 | — |
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| Q11335621 | Nintendo 3DS | 2013 | — |
| Q131426135 | Nintendo 3DS | 2018 | — |
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| Q136655576 | Nintendo Entertainment System | 1990 | GameTek |
| Q136702107 | Nintendo Entertainment System | 1992 | Ocean Software |
| Q141608067 | Nintendo 3DS | 2013 | Alchemist |