| Midnight Bowling | Wii | 2008 | Gameloft |
| Midway Arcade Treasures | Nintendo GameCube | 2003 | Backbone Entertainment |
| Midway Arcade Treasures 2 | Nintendo GameCube | 2004 | Backbone Entertainment |
| Midway Arcade Treasures 3 | Nintendo GameCube | 2005 | Midway Games |
| MiG-29: Soviet Fighter | Nintendo Entertainment System | 1989 | Codemasters |
| Might and Magic Book One: The Secret of the Inner Sanctum | Nintendo Entertainment System | 1990 | New World Computing |
| Might and Magic II: Gates to Another World | Super Nintendo Entertainment System | 1988 | New World Computing |
| Might and Magic III: Isles of Terra | Super Nintendo Entertainment System | 1991 | New World Computing |
| Mighty Bomb Jack | Nintendo Entertainment System | 1986 | Tecmo |
| Mighty Final Fight | Nintendo Entertainment System | 1993 | Capcom |
| Mighty Gunvolt | PlayStation Vita, Nintendo 3DS | 2014 | Inti Creates |
| Mighty Gunvolt Burst | Nintendo 3DS | 2017 | Inti Creates |
| Mighty Morphin Power Rangers | Super Nintendo Entertainment System | 1994 | Winning Entertainment Group |
| Mighty Morphin Power Rangers: The Fighting Edition | Super Nintendo Entertainment System | 1995 | Winning Entertainment Group |
| Mighty Morphin Power Rangers: The Movie | Super Nintendo Entertainment System, Game Boy | 1995 | Winning Entertainment Group |
| Mighty No. 9 | PlayStation Vita, Nintendo 3DS | 2016 | Inti Creates |
| Mighty Switch Force! | Nintendo 3DS | 2011 | WayForward Technologies |
| Mighty Switch Force! 2 | Nintendo 3DS | 2013 | WayForward Technologies |
| Miitopia | Nintendo 3DS | 2016 | Nintendo Entertainment Planning & Development |
| Mikeneko Homuzu no Kishido | Game Boy | 1991 | — |
| Milestone Shooting Collection 2 | Wii | 2010 | Milestone |
| Military Madness: Nectaris | Wii | 2009 | Backbone Entertainment |
| Military Multipurpose Arcade Combat Simulator | Super Nintendo Entertainment System | 1990 | — |
| Millipede | Nintendo Entertainment System | 1982 | Atari, Inc. |
| Milon's Secret Castle | Nintendo Entertainment System, Game Boy | 1986 | Hudson Soft |
| Minecraft | PlayStation Vita, Nintendo 3DS | 2011 | Mojang Studios, Microsoft |
| Minelvaton Saga: Ragon no Fukkatsu | Nintendo Entertainment System | 1987 | Random House |
| Miner 2049er | Game Boy | 1982 | Big Five Software |
| Mini Desktop Racing | Wii | 2005 | Data Design Interactive |
| Mini Golf Resort | Wii | 2010 | Rambo: The Video Game |
| Mini Ninjas | Wii | 2008 | IO Interactive |
| Mini-Putt | Nintendo Entertainment System | 1987 | Artech Digital Entertainment |
| MiniCopter: Adventure Flight | Wii | 2007 | Sonic Powered |
| Minna no Jōshikiryoku Terebi | Wii | 2008 | HAL Laboratory |
| Minon: Everyday Hero | Wii | 2007 | Red Entertainment |
| Minority Report: Everybody Runs | Nintendo GameCube | 2002 | Treyarch, Torus Games |
| Minute to Win It | Wii | 2010 | Smack Down Productions |
| Miracle Girls | Super Nintendo Entertainment System | 1993 | Now Production |
| Miracle Piano Teaching System | Nintendo Entertainment System, Super Nintendo Entertainment System | 1990 | Mindscape |
| Miracle Ropitt: 2100-Nen no Daibōken | Nintendo Entertainment System | 1987 | Micronics |
| Miracle Warriors: Seal of the Dark Lord | Nintendo Entertainment System | 1986 | Kogado Studio |
| Missile Command | Game Boy | 1980 | Atari, Inc. |
| Mission Cobra | Nintendo Entertainment System | 1990 | Thin Chen Enterprise |
| Mission: Impossible | Nintendo Entertainment System | 1990 | Konami |
| Mission: Impossible – Operation Surma | Nintendo GameCube | 2003 | Paradigm Entertainment |
| Mitsume ga Tooru | Nintendo Entertainment System | 1992 | Winning Entertainment Group |
| MLB Power Pros | Wii | 2007 | Konami |
| MLB Power Pros 2008 | Wii | 2008 | Konami |
| MLB Slugfest 20-04 | Nintendo GameCube | 2003 | — |
| MLB Slugfest 2003 | Nintendo GameCube | 2002 | — |
| MLB Superstars | Wii | 2008 | Deep Fried Entertainment |
| MLBPA Baseball | Super Nintendo Entertainment System | 1995 | — |
| Moai-kun | Nintendo Entertainment System | 1990 | Konami |
| Mobile Fighter G Gundam | Super Nintendo Entertainment System | 1994 | — |
| Mobile Suit Gundam F91: Formula Report 0122 | Super Nintendo Entertainment System | 1991 | Bandai |
| Mobile Suit Gundam: Cross Dimension 0079 | Super Nintendo Entertainment System | 1995 | Bandai |
| Mobile Suit Gundam: Gundam vs. Zeta Gundam | Nintendo GameCube | 2004 | Capcom |
| Mobile Suit Gundam: MS Sensen 0079 | Wii | 2007 | Bandai |
| Mobile Suit V Gundam | Super Nintendo Entertainment System | 1994 | — |
| Mobile Suit Z Gundam: Hot Scramble | Nintendo Entertainment System | 1986 | Game Studio |