| Mortal Kombat II | Super Nintendo Entertainment System, Game Boy | 1993 | Midway Games |
| Mortal Kombat II Special | Nintendo Entertainment System | 2000 | Hummer Team |
| Mortal Kombat: Armageddon | Wii | 2006 | Midway Games |
| Mortal Kombat: Deadly Alliance | Nintendo GameCube, Game Boy | 2002 | Midway Games |
| Mortal Kombat: Deception | Nintendo GameCube | 2004 | Midway Games |
| Mother | Nintendo Entertainment System | 1989 | Nintendo |
| Motocross Maniacs | Game Boy | 1989 | Konami |
| MotoGP '08 | Wii | 2008 | Milestone S.r.l. |
| MotoHeroz | Wii | 2011 | RedLynx |
| Motoko-chan no Wonder Kitchen | Super Nintendo Entertainment System | 1993 | Nintendo |
| Motor City Patrol | Nintendo Entertainment System | 1992 | Source Research & Development |
| MotoRace USA | Nintendo Entertainment System | 1983 | Irem |
| Mountain Bike Rally | Super Nintendo Entertainment System | 1994 | Radical Entertainment |
| Mountain Sports | Wii | 2009 | Sproing Interactive Media |
| Mouse Trap Hotel | Game Boy | 1992 | Imagineering |
| Mr Bean | Wii | 2009 | Beyond Reality Games |
| Mr. Chin's Gourmet Paradise | Game Boy | 1990 | Romstar |
| Mr. Do! | Super Nintendo Entertainment System, Game Boy | 1995 | Universal Entertainment |
| Mr. Driller Drill Land | Nintendo GameCube | 2002 | Namco |
| Mr. Nutz | Super Nintendo Entertainment System | 1994 | Ocean Software |
| Mr. Tuff | Super Nintendo Entertainment System | 2023 | The Sales Curve |
| Ms. Pac-Man | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1982 | Midway Games |
| Mujintō Monogatari | Super Nintendo Entertainment System | 1994 | — |
| Multidude | Nintendo Entertainment System | 2019 | Mega Cat Studios |
| Muppet Adventure: Chaos at the Carnival | Nintendo Entertainment System | 1990 | Minds Eye Entertainment |
| Muppets Party Cruise | Nintendo GameCube | 2003 | Mass Media Inc. |
| Muramasa: The Demon Blade | PlayStation Vita, Wii | 2009 | Vanillaware |
| Murder on the Mississippi | Nintendo Entertainment System | 1986 | Activision |
| Musashi no Bōken | Nintendo Entertainment System | 1990 | Quest |
| Musashi no Ken – Tadaima Shugyō Chū | Nintendo Entertainment System | 1986 | Taito |
| Muscle Champion: Kinnikujima no Kessen | Nintendo GameCube | 2002 | Konami |
| Muscle March | Wii | 2009 | Bandai Namco Entertainment |
| Mushroom Men: The Spore Wars | Wii | 2008 | Red Fly Studio |
| Musya | Super Nintendo Entertainment System | 1992 | Jorudan |
| Mutant Fighter | Super Nintendo Entertainment System | 1992 | Data East |
| Mutant Mudds | PlayStation Vita, Nintendo 3DS | 2012 | Renegade Kid |
| Mutant Mudds Super Challenge | PlayStation Vita, Nintendo 3DS | 2016 | Renegade Kid |
| Mutsu to Nohohon | Nintendo GameCube | 2002 | Tomy |
| MVP Baseball 2004 | Nintendo GameCube | 2004 | — |
| MVP Baseball 2005 | Nintendo GameCube | 2005 | EA Vancouver |
| MX Superfly | Nintendo GameCube | 2002 | Locomotive Games |
| MX vs. ATV Untamed | Wii | 2007 | Incinerator Studios |
| My Aquarium | Wii | 2008 | Hudson Soft |
| My Aquarium 2 | Wii | 2010 | Opus Studio Inc. |
| My Baby 2 | Wii | 2009 | Dancing Dots |
| My Baby Pet Hotel 3D | Nintendo 3DS | 2013 | Independent Arts Software |
| My Baby: First Steps | Wii | 2009 | Dancing Dots |
| My Ballet Studio | Wii | 2009 | 505 Games |
| My Body Coach | Wii | 2009 | Neko Entertainment |
| My Fitness Coach | Wii | 2008 | Ubisoft |
| My Fitness Coach 2: Exercise & Nutrition | Wii | 2010 | Ubisoft |
| My French Coach and My Spanish Coach | Wii | 2007 | Sensory Sweep Studios |
| My Hero Academia: Battle for All | Nintendo 3DS | 2016 | — |
| My Horse & Me 2 | Wii | 2008 | Tate Multimedia |
| My Horse and Me | Wii | 2007 | W!Games |
| My Life My Love: Boku no Yume: Watashi no Negai | Nintendo Entertainment System | 1991 | Winkysoft |
| My Nintendo Picross: The Legend of Zelda: Twilight Princess | Nintendo 3DS | 2016 | — |
| My Pokémon Ranch | Wii | 2008 | Ambrella |
| My Style Studio: Hair Salon | Nintendo 3DS | 2013 | Cypronia |
| My Vet Practice | Wii | 2008 | Sproing Interactive Media, Neopica |