| Megami Tensei Gaiden: Last Bible II | Game Boy, Nintendo 3DS | 1993 | — |
| Megamind: Mega Team Unite | Wii | 2010 | THQ Studio Australia |
| Megamind: Ultimate Showdown | Wii | 2010 | THQ |
| Meitantei Conan - Chika yūenchi satsujin jiken | Game Boy | 1996 | — |
| Meitantei Holmes: M-Kara no Chousenjou | Nintendo Entertainment System | 1989 | Another |
| Melfand Stories | Super Nintendo Entertainment System | 1994 | — |
| Men in Black II: Alien Escape | Nintendo GameCube | 2002 | Krome Studios Melbourne |
| Menace Beach | Nintendo Entertainment System | 1990 | Color Dreams |
| Mendel Palace | Nintendo Entertainment System | 1989 | Game Freak |
| Mercedes-Benz World Racing | Nintendo GameCube | 2003 | Synetic GmbH |
| Mercenary Force | Game Boy | 1990 | — |
| Mercury Meltdown Revolution | Wii | 2007 | UTV Ignition Games |
| Merv Griffin's Crosswords | Wii | 2008 | Pipeworks Software |
| Metal Arms: Glitch in the System | Nintendo GameCube | 2003 | Swingin' Ape Studios |
| Metal Combat: Falcon's Revenge | Super Nintendo Entertainment System | 1993 | Intelligent Systems |
| Metal Fighter | Nintendo Entertainment System | 1989 | Thin Chen Enterprise |
| Metal Gear | Nintendo Entertainment System, Nintendo GameCube, PlayStation Vita | 1987 | Konami |
| Metal Gear Solid: Snake Eater 3D | Nintendo 3DS | 2012 | Kojima Productions |
| Metal Gear Solid: The Twin Snakes | Nintendo GameCube | 2004 | Silicon Knights |
| Metal Marines | Super Nintendo Entertainment System | 1993 | Namco |
| Metal Masters | Game Boy | 1993 | Bit Managers |
| Metal Max | Nintendo Entertainment System, Super Nintendo Entertainment System | 1991 | Crea-Tech |
| Metal Max 2 | Super Nintendo Entertainment System | 1993 | Crea-Tech |
| Metal Max 4: Gekkō no Diva | Nintendo 3DS | 2013 | — |
| Metal Mech | Nintendo Entertainment System | 1990 | Sculptured Software |
| Metal Morph | Super Nintendo Entertainment System | 1994 | Origin Systems |
| Metal Slader Glory | Nintendo Entertainment System, Super Nintendo Entertainment System | 1991 | HAL Laboratory |
| Metal Slug Anthology | Wii | 2006 | Terminal Reality |
| Metal Storm | Nintendo Entertainment System | 1991 | GameFAQs |
| Metal Warriors | Super Nintendo Entertainment System | 1995 | Lucasfilm Games |
| Metro-Cross | Nintendo Entertainment System | 1985 | Namco |
| Metroid | Nintendo Entertainment System | 1986 | Nintendo Research & Development 1 |
| Metroid II: Return of Samus | Game Boy, Nintendo 3DS | 1991 | Nintendo Research & Development 1 |
| Metroid Prime | Nintendo GameCube, Wii | 2002 | Retro Studios |
| Metroid Prime 2: Echoes | Nintendo GameCube, Wii | 2004 | Retro Studios |
| Metroid Prime 3: Corruption | Wii | 2007 | Retro Studios |
| Metroid Prime: Federation Force | Nintendo 3DS | 2016 | Next Level Games |
| Metroid Prime: Trilogy | Wii | 2009 | Retro Studios |
| Metroid: Other M | Wii | 2010 | D-Rockets, Nintendo Software Planning & Development, Team Ninja |
| Metroid: Samus Returns | Nintendo 3DS | 2017 | Nintendo Entertainment Planning & Development, MercurySteam |
| Mezase! Top Pro: Green ni Kakeru Yume | Nintendo Entertainment System | 1993 | Tose Co. |
| MIB: Alien Crisis | Wii | 2012 | Modus Studios Bucharest |
| Miburi & Teburi | Wii | 2008 | Climax Entertainment |
| Michael Andretti's Indy Car Challenge | Super Nintendo Entertainment System | 1994 | Genki |
| Michael Andretti's World GP | Nintendo Entertainment System | 1988 | Human Entertainment |
| Michael Jackson: The Experience | PlayStation Vita, Nintendo 3DS, Wii | 2010 | Ubisoft Montpellier |
| Michael Jordan: Chaos in the Windy City | Super Nintendo Entertainment System | 1994 | Electronic Arts |
| Mickey Mania | Super Nintendo Entertainment System | 1994 | Traveller's Tales |
| Mickey Mouse: Magic Wands! | Game Boy | 1993 | Kemco |
| Mickey Mousecapade | Nintendo Entertainment System | 1987 | Hudson Soft |
| Mickey no Tokyo Disneyland Daibōken | Super Nintendo Entertainment System | 1994 | — |
| Mickey's Adventures in Numberland | Nintendo Entertainment System | 1994 | Krome Studios Melbourne |
| Mickey's Dangerous Chase | Game Boy | 1991 | Now Production |
| Mickey's Safari in Letterland | Nintendo Entertainment System | 1993 | Krome Studios Melbourne |
| Mickey's Ultimate Challenge | Super Nintendo Entertainment System | 1994 | Disney Interactive Studios |
| Micro Machines | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1991 | Codemasters |
| Micro Machines | Nintendo GameCube | 2002 | Gremlin Interactive |
| Micro Machines 2: Turbo Tournament | Super Nintendo Entertainment System, Game Boy | 1994 | Codemasters |
| Micro Mages | Nintendo Entertainment System | 2019 | Morphcat Games |
| MIDI Maze | Super Nintendo Entertainment System, Game Boy | 1987 | — |