| Marvelous: Mōhitotsu no Takarajima | Super Nintendo Entertainment System | 1996 | Nintendo Research & Development 2 |
| Mary Shelley's Frankenstein | Super Nintendo Entertainment System | 1994 | Bits Studios |
| Mary-Kate and Ashley: Sweet 16 Licensed to Drive | Nintendo GameCube | 2003 | — |
| Master Chu and the Drunkard Hu | Nintendo Entertainment System | 1989 | Thin Chen Enterprise |
| Master Takahashi's Adventure Island IV | Nintendo Entertainment System | 1994 | Hudson Soft |
| Masuzoe Youichi: Asa Made Famicom | Nintendo Entertainment System | 1992 | Coconuts Japan |
| Mat Hoffman's Pro BMX 2 | Nintendo GameCube | 2002 | THQ |
| Matchman | Wii | 2008 | — |
| Math Blaster Episode I: In Search of Spot | Super Nintendo Entertainment System | 1994 | Davidson & Associates |
| Mathews Bowhunting | Wii | 2010 | Zoo Corporation |
| Matsukata Hiroki no Super Trawling | Super Nintendo Entertainment System | 1995 | — |
| Matsumura Kunihiro Den: Saikyō no Rekishi o Nurikaero! | Super Nintendo Entertainment System | 1994 | — |
| Maui Mallard in Cold Shadow | Super Nintendo Entertainment System, Game Boy | 1995 | Disney Interactive Studios |
| Max & the Magic Marker | Wii | 2010 | Press Play |
| Maximum Racing: Drag & Stock Racer | Wii | 2010 | Brain in a Jar |
| Maximum Racing: GP Classic Racing | Wii | 2010 | Brain in a Jar |
| MaxPlay Classic Games Volume 1 | Nintendo GameCube | 2004 | Action Replay |
| Mazinger Z | Super Nintendo Entertainment System | 1993 | Winkysoft |
| MC Groovz Dance Craze | Nintendo GameCube | 2004 | Mad Catz |
| Mecarobot Golf | Super Nintendo Entertainment System | 1992 | — |
| Mechanized Attack | Nintendo Entertainment System | 1989 | SNK |
| MechWarrior | Super Nintendo Entertainment System | 1993 | Krome Studios Melbourne |
| MechWarrior 3050 | Super Nintendo Entertainment System | 1994 | EA Orlando |
| Medabots Infinity | Nintendo GameCube | 2003 | Victor Interactive Software |
| Medal of Honor: European Assault | Nintendo GameCube | 2005 | Danger Close Games |
| Medal of Honor: Frontline | Nintendo GameCube | 2002 | Danger Close Games |
| Medal of Honor: Heroes 2 | Wii | 2007 | Danger Close Games |
| Medal of Honor: Rising Sun | Nintendo GameCube | 2003 | Danger Close Games |
| Medal of Honor: Vanguard | Wii | 2007 | Budcat Creations |
| Medieval games | Wii | 2009 | N-Fusion Interactive |
| Meet the Robinsons | Nintendo GameCube, Wii | 2007 | Climax Studios |
| Mega Lo Mania | Super Nintendo Entertainment System | 1991 | Sensible Software |
| Mega Man | Nintendo Entertainment System, Nintendo 3DS, Wii | 1987 | Capcom |
| Mega Man & Bass | Super Nintendo Entertainment System | 1998 | Capcom |
| Mega Man 10 | Wii | 2010 | Inti Creates |
| Mega Man 2 | Nintendo Entertainment System | 1988 | Capcom |
| Mega Man 3 | Nintendo Entertainment System | 1990 | Capcom |
| Mega Man 4 | Nintendo Entertainment System | 1991 | Capcom |
| Mega Man 5 | Nintendo Entertainment System | 1992 | Capcom |
| Mega Man 6 | Nintendo Entertainment System | 1993 | Capcom |
| Mega Man 7 | Super Nintendo Entertainment System | 1995 | Capcom |
| Mega Man 9 | Wii | 2008 | Inti Creates |
| Mega Man Anniversary Collection | Nintendo GameCube | 2004 | Atomic Planet Entertainment |
| Mega Man II | Game Boy | 1991 | — |
| Mega Man III | Game Boy | 1992 | Capcom |
| Mega Man IV | Game Boy | 1993 | Capcom |
| Mega Man Legacy Collection | Nintendo 3DS | 2015 | Capcom |
| Mega Man Legends 3 | Nintendo 3DS | — | Capcom |
| Mega Man Network Transmission | Nintendo GameCube | 2010 | Arika |
| Mega Man Soccer | Super Nintendo Entertainment System | 1994 | Capcom |
| Mega Man V | Game Boy | 1994 | Capcom |
| Mega Man X | Super Nintendo Entertainment System, Wii | 1993 | Capcom |
| Mega Man X Collection | Nintendo GameCube | 2006 | Capcom |
| Mega Man X2 | Super Nintendo Entertainment System | 1994 | Capcom |
| Mega Man X3 | Super Nintendo Entertainment System | 1995 | Capcom |
| Mega Man X: Command Mission | Nintendo GameCube | 2004 | Capcom |
| Mega Man Xtreme | Nintendo 3DS | 2000 | Capcom |
| Mega Man: Dr. Wily's Revenge | Game Boy | 1991 | Capcom |
| Megalit | Game Boy | 1991 | ASCII Corporation |
| Megami Meguri | Nintendo 3DS | 2016 | Capcom |