| Madden NFL 10 | Wii | 2009 | EA Orlando |
| Madden NFL 11 | Wii | 2010 | EA Orlando |
| Madden NFL 12 | Wii | 2011 | EA Orlando |
| Madden NFL 13 | PlayStation Vita, Wii | 2012 | EA Orlando |
| Madden NFL 2002 | Nintendo GameCube | 2001 | EA Orlando |
| Madden NFL 2003 | Nintendo GameCube | 2002 | EA Orlando |
| Madden NFL 2004 | Nintendo GameCube | 2003 | EA Orlando |
| Madden NFL 2005 | Nintendo GameCube | 2004 | EA Orlando |
| Madden NFL 97 | Super Nintendo Entertainment System, Game Boy | 1996 | EA Orlando |
| Madden NFL 98 | Super Nintendo Entertainment System | 1997 | EA Orlando |
| Madden NFL Football | Nintendo 3DS | 2011 | EA Sports |
| MadStone | Wii | 2008 | RiverMan Media |
| MadWorld | Wii | 2009 | PlatinumGames |
| Madō Monogatari: Hanamaru Daiyōchienji | Super Nintendo Entertainment System | 1996 | Compile |
| Magic Boy | Super Nintendo Entertainment System | 1993 | Empire Interactive |
| Magic Darts | Nintendo Entertainment System | 1991 | Romstar |
| Magic Jewelry | Nintendo Entertainment System | 1990 | Hwang Shinwei |
| Magic Johnson's Fast Break | Nintendo Entertainment System | 1988 | Arcadia Systems |
| Magic Knight Rayearth | Super Nintendo Entertainment System | 1995 | — |
| Magic Sword: Heroic Fantasy | Super Nintendo Entertainment System | 1990 | Capcom |
| Magical Drop | Super Nintendo Entertainment System | 1995 | Data East |
| Magical Drop II | Super Nintendo Entertainment System | 1996 | — |
| Magical Pop'n | Super Nintendo Entertainment System | 1995 | — |
| Magical Tarurūto-kun: Magic Adventure | Super Nintendo Entertainment System | 1992 | Game Freak |
| Magician | Nintendo Entertainment System | 1991 | Eurocom |
| MagMax | Nintendo Entertainment System | 1986 | Nichibutsu |
| Magna Braban: Henreki no Yusha | Super Nintendo Entertainment System | 1994 | — |
| Magnetic Soccer | Game Boy | 1992 | — |
| Mahjong 3D Essentials | Nintendo 3DS | 2013 | YipYip |
| Mahjong 3D Warriors of the Emperor | Nintendo 3DS | 2012 | YipYip |
| Mahjong Cub3d | Nintendo 3DS | 2011 | Sunsoft |
| Mahjong Taikai Wii | Wii | 2007 | Koei |
| Mahjong Wii | Wii | 2007 | Koei |
| Mahōjin Guru Guru | Super Nintendo Entertainment System | 1995 | — |
| Mahōjin Guru Guru 2 | Super Nintendo Entertainment System | 1996 | — |
| Majin Bone: Jikan to Kūkan no Majin | Nintendo 3DS | 2014 | — |
| Majin Tensei | Super Nintendo Entertainment System | 1994 | Atlus |
| Majin Tensei II: Spiral Nemesis | Super Nintendo Entertainment System, Wii | 1995 | Atlus |
| Majo-tachi no Nemuri | Super Nintendo Entertainment System | 1995 | — |
| Major Dream: Major Wii Nagero! Gyroball!! | Wii | 2008 | DreamFactory |
| Major League Baseball | Nintendo Entertainment System | 1988 | Atlus |
| Major League Baseball 2K10 | Wii | 2010 | Visual Concepts |
| Major League Baseball 2K11 | Wii | 2011 | Visual Concepts |
| Major League Baseball 2K12 | Wii | 2012 | Visual Concepts |
| Major League Baseball 2K6 | Nintendo GameCube | 2006 | Visual Concepts |
| Major League Baseball 2K8 | Wii | 2008 | 2K Los Angeles |
| Major League Baseball 2K9 | Wii | 2009 | Visual Concepts |
| Major Minor's Majestic March | Wii | 2009 | NanaOn-Sha |
| Major Title | Super Nintendo Entertainment System | 1992 | Irem |
| Major Wii: Perfect Closer | Wii | 2008 | DreamFactory |
| Majyūō | Super Nintendo Entertainment System | 1995 | KSS |
| Majō Densetsu II: Daimashikyō Galious | Nintendo Entertainment System | 1987 | Konami |
| Maka Maka | Super Nintendo Entertainment System | 1992 | Shōei System, Office Koukan |
| Makeruna! Makendō 2: Kimero Youkai Souri | Super Nintendo Entertainment System | 1995 | Success |
| Man vs. Wild | Wii | 2011 | Scientifically Proven |
| Manchester United Championship Soccer | Super Nintendo Entertainment System | — | Krisalis Software |
| Manhunt 2 | Wii | 2007 | Rockstar London |
| Maniac Mansion | Nintendo Entertainment System, Apple II series | 1987 | Lucasfilm Games |
| Mappy | Nintendo Entertainment System | 1984 | Namco |
| Mappy Kids | Nintendo Entertainment System | 1989 | Namco |