| Doraemon 4 | Super Nintendo Entertainment System | 1995 | Agenda |
| Doraemon Wii | Wii | 2007 | Eighting |
| Doraemon: Giga Zombie no Gyakushū | Nintendo Entertainment System | 1990 | Epoch Co. |
| Doraemon: Minna de Asobō! Minidorando | Nintendo GameCube | 2003 | Epoch Co. |
| Doraemon: Nobita and the Island of Miracles ~Animal Adventure~ | Nintendo 3DS | 2012 | — |
| Doraemon: Nobita to Yousei no Kuni | Super Nintendo Entertainment System | 1993 | — |
| DoReMi Fantasy | Super Nintendo Entertainment System | 1996 | Hudson Soft |
| Dorke and Ymp | Super Nintendo Entertainment System | 2015 | — |
| Doshin the Giant | Nintendo GameCube | 1999 | Param |
| Dossun! Ganseki Battle | Super Nintendo Entertainment System | 1994 | — |
| Double Breakout | Nintendo 3DS | 2016 | nuGAME |
| Double Dare | Nintendo Entertainment System | 1988 | Rare Ltd. |
| Double Dragon | Nintendo Entertainment System, Nintendo 3DS | 1987 | Technōs Japan |
| Double Dragon 3: The Rosetta Stone | Game Boy | 1990 | East Technology Corp. |
| Double Dragon II | Game Boy | 1990 | Technōs Japan |
| Double Dragon II: The Revenge | Nintendo Entertainment System, Wii | 1989 | Technōs Japan |
| Double Dragon III: The Sacred Stones | Nintendo Entertainment System | 1991 | Technōs Japan |
| Double Dragon V: The Shadow Falls | Super Nintendo Entertainment System | 1994 | Leland Interactive Media |
| Double Dribble | Nintendo Entertainment System | 1987 | Konami |
| Double Moon Densetsu | Nintendo Entertainment System | 1992 | Nippon Computer Systems |
| Double Strike | Nintendo Entertainment System | 1990 | — |
| Doubutsu Kisoutengai | Wii | 2008 | Success |
| Dough Boy | Nintendo Entertainment System | 1985 | Synapse Software |
| Down the World: Mervil's Ambition | Super Nintendo Entertainment System | 1994 | — |
| Downtown Nekketsu Baseball Monogatari | Super Nintendo Entertainment System | 1993 | — |
| Downtown Nekketsu March: Super-Awesome Field Day! | Nintendo Entertainment System | 1990 | Technōs Japan |
| Downtown Run | Nintendo GameCube | 2003 | Ubisoft |
| Downtown Special: Kunio-kun's Historical Period Drama! | Nintendo Entertainment System, Game Boy, Nintendo 3DS | 1991 | Technōs Japan |
| Dr. Chaos | Nintendo Entertainment System | 1987 | Pony Canyon |
| Dr. Franken | Game Boy | 1992 | Motivetime Ltd. |
| Dr. Jekyll and Mr. Hyde | Nintendo Entertainment System | 1988 | Advance Communication |
| Dr. Mario | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1990 | Nintendo Research & Development 1 |
| Dr. Mario Online Rx | Wii | 2008 | Arika |
| Dr. Mario: Miracle Cure | Nintendo 3DS | 2015 | Arika |
| Dr. Muto | Nintendo GameCube | 2002 | Midway Games |
| Dr. Robotnik's Mean Bean Machine | Wii | 1993 | Sonic Team |
| Drac's Night Out | Nintendo Entertainment System | 1991 | — |
| Dracula: Undead Awakening | Wii | 2009 | Moregames Entertainment |
| Dragon Ball 3: Gokūden | Nintendo Entertainment System | 1989 | Tose Co. |
| Dragon Ball Fusions | Nintendo 3DS | 2016 | Ganbarion |
| Dragon Ball Z III: Ressen Jinzou Ningen | Nintendo Entertainment System | 1992 | Tose Co. |
| Dragon Ball Z Side Story: Plan to Eradicate the Saiyans | Nintendo Entertainment System | 1993 | Tose Co. |
| Dragon Ball Z: Budokai | Nintendo GameCube | 2002 | Dimps |
| Dragon Ball Z: Budokai 2 | Nintendo GameCube | 2003 | Dimps |
| Dragon Ball Z: Budokai Tenkaichi 3 | Wii | 2007 | Spike |
| Dragon Ball Z: Extreme Butōden | Nintendo 3DS | 2015 | Arc System Works |
| Dragon Ball Z: Hyper Dimension | Super Nintendo Entertainment System | 1996 | Bandai |
| Dragon Ball Z: Sagas | Nintendo GameCube | 2005 | Avalanche Software |
| Dragon Ball Z: Super Butōden | Super Nintendo Entertainment System | 1993 | Bandai |
| Dragon Ball Z: Super Butōden 2 | Super Nintendo Entertainment System | 1993 | Bandai |
| Dragon Ball Z: Super Butōden 3 | Super Nintendo Entertainment System | 1994 | Bandai |
| Dragon Ball Z: Super Gokuden - Kakusei-Hen | Super Nintendo Entertainment System | 1995 | — |
| Dragon Ball Z: Super Gokuden - Totsugeki-Hen | Super Nintendo Entertainment System | 1995 | — |
| Dragon Ball Z: Super Saiya Densetsu | Super Nintendo Entertainment System | 1992 | Tose Co. |
| Dragon Ball: Daimaō fukkatsu | Nintendo Entertainment System | 1988 | Bandai |
| Dragon Ball: Revenge of King Piccolo | Wii | 2009 | Media.Vision |
| Dragon Blade: Wrath of Fire | Wii | 2007 | D3 Publisher |
| Dragon Buster | Nintendo Entertainment System | 1985 | Namco |
| Dragon Drive: D-Masters Shot | Nintendo GameCube | 2003 | Treasure |
| Dragon Fighter | Nintendo Entertainment System | 1990 | Winning Entertainment Group |