| Disney's Party | Nintendo GameCube | 2003 | Neverland |
| Disney's Pocahontas | Game Boy | 1996 | Tiertex Design Studios, Funcom |
| Disney's Tarzan: Untamed | Nintendo GameCube | 2001 | Disney Interactive Studios, Ubisoft Montreal |
| Diva Girls: Divas on Ice | Wii | 2009 | Arc System Works |
| Dive: The Medes Islands Secret | Wii | 2010 | Over the Top Games |
| Dizzy: Prince of the Yolkfolk | Nintendo Entertainment System | 1991 | Big Red Software |
| DJ Hero | Wii | 2009 | Ubisoft Leamington |
| DJ Hero 2 | Wii | 2010 | Ubisoft Leamington |
| Do I Pass | Game Boy | 2019 | Taylor McCue |
| Doc Louis's Punch-Out!! | Wii | 2009 | Next Level Games |
| Doctor Lautrec and the Forgotten Knights | Nintendo 3DS | 2011 | Konami |
| Doctor Who: Return to Earth | Wii | 2010 | Asylum Entertainment |
| Dodge Racing: Charger vs. Challenger | Nintendo 3DS, Wii | 2009 | Extra Mile Studios |
| Dokapon DX: Wataru Sekai wa Oni Darake | Nintendo GameCube | 2003 | Asmik Ace Entertainment |
| Dokapon Kingdom | Wii | 2007 | Sting |
| Doki! Doki! Yūenchi: Crazy Land Daisakusen | Nintendo Entertainment System | 1991 | KID |
| Doll Fashion Atelier | Nintendo 3DS | — | Studio Mebius |
| Dolucky no Kusayakiu | Super Nintendo Entertainment System | 1993 | Zoom |
| Dolucky no Puzzle Tour '94 | Super Nintendo Entertainment System | 1994 | Zoom |
| Dolucky's A-League Soccer | Super Nintendo Entertainment System | 1994 | Zoom |
| Don Doko Don | Nintendo Entertainment System | 1989 | Taito |
| Don Doko Don 2 | Nintendo Entertainment System | 1992 | Taito |
| Don King Boxing | Wii | 2009 | 2K China |
| Donald Duck: Goin' Quackers | Nintendo GameCube | 2000 | Ubisoft Montreal |
| Donald In the Magic Cap | Super Nintendo Entertainment System | 1995 | — |
| Donald Land | Nintendo Entertainment System | 1988 | Data East |
| Donkey Kong | Nintendo Entertainment System | 1981 | Nintendo Research & Development 1, Ikegami Tsushinki, Nintendo |
| Donkey Kong | Game Boy | 1994 | Nintendo Entertainment Analysis & Development |
| Donkey Kong 3 | Nintendo Entertainment System | 1984 | Nintendo |
| Donkey Kong Barrel Blast | Wii | 2007 | Paon DP |
| Donkey Kong Classics | Nintendo Entertainment System | 1988 | Nintendo Entertainment Analysis & Development, Nintendo |
| Donkey Kong Country | Super Nintendo Entertainment System, Wii | 1994 | Rare Ltd. |
| Donkey Kong Country 2: Diddy's Kong Quest | Super Nintendo Entertainment System | 1995 | Rare Ltd. |
| Donkey Kong Country 3: Dixie Kong's Double Trouble! | Super Nintendo Entertainment System | 1996 | Rare Ltd. |
| Donkey Kong Country Returns | Wii | 2010 | Retro Studios |
| Donkey Kong Country Returns 3D | Nintendo 3DS | 2013 | — |
| Donkey Kong Jr. | Nintendo Entertainment System | 1982 | Nintendo |
| Donkey Kong Jr. Math | Nintendo Entertainment System | 1983 | Nintendo Research & Development 2 |
| Donkey Kong Jungle Beat | Nintendo GameCube, Wii | 2004 | Nintendo Entertainment Analysis & Development |
| Donkey Kong Land | Game Boy | 1995 | Rare Ltd. |
| Donkey Kong Land 2 | Game Boy | 1996 | Rare Ltd. |
| Donkey Kong Land III | Game Boy | 1997 | Rare Ltd. |
| Donkey Konga | Nintendo GameCube | 2003 | Namco |
| Donkey Konga 2 | Nintendo GameCube | 2004 | Namco |
| Donkey Konga 3 | Nintendo GameCube | 2005 | Namco |
| Dood's Big Adventure | Wii | 2010 | Rainbow Studios |
| Doodle Jump | Nintendo 3DS | 2009 | Lima Sky |
| Doodle Jump Adventures | Nintendo 3DS | — | Smoking Gun Interactive |
| Dooly Bravo Land | Nintendo Entertainment System | 1992 | Daou Infosys |
| Doom | Super Nintendo Entertainment System | 1993 | Nerve Software, id Software |
| Doom Troopers: Mutant Chronicles | Super Nintendo Entertainment System | 1995 | — |
| Doomsday Warrior | Super Nintendo Entertainment System | 1992 | — |
| Door Door | Nintendo Entertainment System | 1983 | Koichi Nakamura |
| Dora the Explorer: Dora Saves the Crystal Kingdom | Wii | 2009 | High Voltage Software |
| Dora the Explorer: Dora Saves the Snow Princess | Wii | 2008 | High Voltage Software |
| Dora the Explorer: Dora's Big Birthday Adventure | Wii | 2010 | High Voltage Software |
| Dora the Explorer: Journey to the Purple Planet | Nintendo GameCube | 2005 | Monkey Bar Games |
| Doraemon | Nintendo Entertainment System | 1986 | Hudson Soft |
| Doraemon 2: Nobita no Toys Land Daibouken | Super Nintendo Entertainment System | 1993 | SAS Sakata |
| Doraemon 3 | Super Nintendo Entertainment System | 1994 | Fortyfive |