| Dragon Knight 4 | Super Nintendo Entertainment System | 1994 | ELF Corporation |
| Dragon Lapis | Nintendo 3DS | 2020 | Exe-Create |
| Dragon Power | Nintendo Entertainment System | 1986 | Bandai |
| Dragon Quest | Nintendo Entertainment System, Super Nintendo Entertainment System, Nintendo 3DS, Wii | 1986 | Chunsoft |
| Dragon Quest 25 Shuunen Kinen: Famicom & Super Famicom Dragon Quest I-II-III | Wii | 2011 | Square Enix |
| Dragon Quest 25 Shūnen Kinen Famicom & Super Famicom Dragon Quest I・II・III | Wii | 2011 | Square Enix |
| Dragon Quest II | Nintendo Entertainment System, Super Nintendo Entertainment System | 1987 | Chunsoft |
| Dragon Quest III | Nintendo Entertainment System, Super Nintendo Entertainment System | 1988 | Chunsoft |
| Dragon Quest IV | Nintendo Entertainment System | 1990 | Chunsoft |
| Dragon Quest Monsters: Joker 3 | Nintendo 3DS | 2016 | Tose Co. |
| Dragon Quest Swords | Wii | 2007 | Genius Sonority |
| Dragon Quest V | Super Nintendo Entertainment System | 1992 | Chunsoft |
| Dragon Quest VI | Super Nintendo Entertainment System | 1995 | Heartbeat |
| Dragon Quest VIII | Nintendo 3DS | 2004 | Level-5 |
| Dragon Quest X | Nintendo 3DS, Wii | 2012 | Square Enix, Yuji Horii |
| Dragon Quest XI | Nintendo 3DS | 2017 | Square Enix |
| Dragon Quest: Monster Battle Road | Wii | 2008 | Eighting |
| Dragon Saber | Wii | 1990 | Namco |
| Dragon Scroll | Nintendo Entertainment System | 1987 | Konami |
| Dragon Slayer | Game Boy | 1984 | Nihon Falcom |
| Dragon Slayer: The Legend of Heroes | Super Nintendo Entertainment System | 1989 | Nihon Falcom |
| Dragon Slayer: The Legend of Heroes II | Super Nintendo Entertainment System | 1992 | Nihon Falcom |
| Dragon Spirit: The New Legend | Nintendo Entertainment System | 1989 | Namco |
| Dragon Squadron: Danzarb | Super Nintendo Entertainment System | 1993 | — |
| Dragon View | Super Nintendo Entertainment System | 1994 | Atari |
| Dragon Wars | Nintendo Entertainment System, Apple II series | 1991 | Interplay Entertainment |
| Dragon's Earth | Super Nintendo Entertainment System | 1993 | Human Entertainment |
| Dragon's Lair | Super Nintendo Entertainment System | 1992 | — |
| Dragon's Lair | Nintendo Entertainment System | 1990 | Motivetime Ltd. |
| Dragon's Lair 3D: Return to the Lair | Nintendo GameCube | 2002 | Dragonstone Software |
| Dragon's Lair Trilogy | Wii | 2010 | Digital Leisure, Dimitrij |
| Dragon: The Bruce Lee Story | Super Nintendo Entertainment System | 1994 | Virgin Interactive |
| DragonHeart: Fire & Steel | Game Boy | 1996 | Funcom |
| Dragons of Flame | Nintendo Entertainment System | 1989 | U.S. Gold |
| DragonStrike | Nintendo Entertainment System | 1992 | Westwood Studios, Pony Canyon |
| Drakkhen | Super Nintendo Entertainment System | 1989 | Infogrames |
| Drawn to Life: The Next Chapter | Wii | 2009 | Planet Moon Studios |
| Dream Basketball: Dunk & Hoop | Super Nintendo Entertainment System | 1994 | — |
| Dream Dance & Cheer | Wii | 2009 | indiePub |
| Dream Master | Nintendo Entertainment System | 1992 | Birthday |
| Dream Pinball 3D | Wii | 2008 | TopWare Interactive |
| Dream Salon | Wii | 2009 | CyberPlanet Interactive |
| Dream Trigger 3D | Nintendo 3DS | 2011 | Art Co., Ltd |
| Dream TV | Super Nintendo Entertainment System | 1994 | — |
| DreamMix TV World Fighters | Nintendo GameCube | 2003 | Hudson Soft |
| Dreamworld Pogie | Nintendo Entertainment System | 2016 | Oliver Twins |
| Driift Mania | Wii | 2009 | Konami |
| Drill Sergeant Mindstrong | Wii | 2009 | Xseed Games |
| Driven | Nintendo GameCube | 2001 | BAM! Entertainment |
| Driver: Parallel Lines | Wii | 2006 | Ubisoft Reflections |
| Driver: Renegade | Nintendo 3DS | 2011 | Ubisoft |
| Driver: San Francisco | Wii | 2011 | Ubisoft Reflections |
| Drome Racers | Nintendo GameCube | 2002 | — |
| Drone Fight | Nintendo 3DS | 2016 | SilverStarJapan Co., Ltd. |
| Dropzone | Nintendo Entertainment System | 1984 | Archer Maclean |
| DSiWare | Nintendo 3DS | 2009 | Nintendo |
| DT: Lords of Genomes | Game Boy | 2001 | — |
| Dual Orb | Super Nintendo Entertainment System | 1993 | — |
| Dual Orb II | Super Nintendo Entertainment System | 1994 | Nippon Ichi Software |
| DualPenSports | Nintendo 3DS | 2011 | indieszero |