| Dexterity | Game Boy | 1990 | SNK |
| Dezaemon | Nintendo Entertainment System | 1991 | Athena |
| Dian Shi Mali | Nintendo Entertainment System | 1989 | — |
| Diatomic | Wii | 2009 | Grendel Games |
| Dick Tracy | Nintendo Entertainment System, Game Boy | 1990 | Realtime Associates |
| Die Hard | Nintendo Entertainment System | 1991 | Pack-In-Video |
| Die Hard: Vendetta | Nintendo GameCube | 2002 | Bits Studios |
| Dig & Spike Volleyball | Super Nintendo Entertainment System | 1992 | Tose Co. |
| Dig Dug | Nintendo Entertainment System, Game Boy | 1982 | Namco |
| Dig Dug II | Nintendo Entertainment System | 1985 | Namco |
| Digger T. Rock | Nintendo Entertainment System | 1990 | Rare Ltd. |
| Digimon Rumble Arena 2 | Nintendo GameCube | 2004 | Bandai Namco Entertainment |
| Digimon Universe: Appli Monsters | Nintendo 3DS | 2016 | Inti Creates |
| Digimon World 4 | Nintendo GameCube | 2005 | Bandai |
| Digimon World Re:Digitize Decode | Nintendo 3DS | 2013 | tri-Crescendo |
| Digital Devil Story: Megami Tensei | Nintendo Entertainment System | 1987 | Atlus |
| Digital Devil Story: Megami Tensei II | Nintendo Entertainment System | 1990 | Atlus |
| Dillon's Dead-Heat Breakers | Nintendo 3DS | 2018 | — |
| Dillon's Rolling Western | Nintendo 3DS | 2012 | Vanpool |
| Dillon's Rolling Western: The Last Ranger | Nintendo 3DS | 2013 | Vanpool |
| Diner Dash | Wii | 2003 | Gamelab |
| Diner Dash: Hometown Hero | Wii | 2007 | PlayFirst |
| Dino Breeder | Game Boy | 1997 | — |
| Dino Breeder 2 | Game Boy | 1998 | — |
| Dino Dini's Goal | Super Nintendo Entertainment System | 1993 | Dino Dini |
| Dino Dini's Soccer | Super Nintendo Entertainment System | 1994 | Dino Dini |
| Dino Strike | Wii | 2011 | N-Fusion Interactive |
| DinoCity | Super Nintendo Entertainment System | 1992 | Irem |
| Dinotopia: The Sunstone Odyssey | Nintendo GameCube | 2003 | Vicious Cycle Software |
| Dirt Trax FX | Super Nintendo Entertainment System | 1995 | Sculptured Software |
| Dirty Harry | Nintendo Entertainment System | 1990 | Mindscape |
| Dirty Racing | Game Boy | 1993 | Gremlin Interactive |
| Disaster: Day of Crisis | Wii | 2008 | Monolith Soft Inc. |
| Disney Art Academy | Nintendo 3DS | 2016 | Headstrong Games |
| Disney Channel All Star Party | Wii | 2010 | Page 44 Studios |
| Disney Infinity | Wii | 2013 | Avalanche Software |
| Disney Magical World | Nintendo 3DS | 2013 | h.a.n.d. |
| Disney Magical World 2 | Nintendo 3DS | 2015 | h.a.n.d. |
| Disney Princess: Enchanted Journey | Wii | 2007 | Papaya Studio |
| Disney Princess: Enchanting Storybooks | Wii | 2011 | Page 44 Studios |
| Disney Sing It | Wii | 2008 | Zoë Mode |
| Disney Sing It! – High School Musical 3: Senior Year | Wii | 2008 | Zoë Mode |
| Disney Sing It: Family Hits | Wii | 2010 | Zoë Mode |
| Disney Sing It: Party Hits | Wii | 2010 | Zoë Mode |
| Disney Sing It: Pop Hits | Wii | 2009 | Zoë Mode |
| Disney Sports Basketball | Nintendo GameCube | 2002 | Konami |
| Disney Sports Football | Nintendo GameCube | 2002 | Konami |
| Disney Sports Skateboarding | Nintendo GameCube | 2002 | Konami |
| Disney Sports Soccer | Nintendo GameCube | 2002 | Konami |
| Disney Think Fast | Wii | 2008 | Magenta Software |
| Disney Universe | Wii | 2011 | Eurocom |
| Disney's Aladdin | Nintendo Entertainment System, Game Boy | 1993 | Virgin Interactive |
| Disney's Aladdin | Super Nintendo Entertainment System | 1993 | Capcom |
| Disney's Beauty and the Beast | Super Nintendo Entertainment System | 1994 | — |
| Disney's Chicken Little: Ace in Action | Wii | 2006 | Avalanche Software |
| Disney's Extreme Skate Adventure | Nintendo GameCube | 2003 | Toys for Bob |
| Disney's Hide and Sneak | Nintendo GameCube | 2003 | Capcom |
| Disney's Magical Mirror Starring Mickey Mouse | Nintendo GameCube | 2002 | Capcom |
| Disney's Magical Quest 3 Starring Mickey & Donald | Super Nintendo Entertainment System | 1995 | Capcom |
| Disney's Mulan | Game Boy | — | Tiertex Design Studios |