| Duck | Nintendo Entertainment System | 1987 | Bit Corporation |
| Duck Hunt | Nintendo Entertainment System | 1984 | Nintendo Research & Development 1 |
| DuckTales | Nintendo Entertainment System, Game Boy | 1989 | Capcom |
| DuckTales 2 | Nintendo Entertainment System, Game Boy | 1993 | Capcom |
| Duel Masters Nettou! Battle Arena | Nintendo GameCube | 2003 | Takara |
| Dungeon Kid | Nintendo Entertainment System | 1990 | Quest |
| Dungeon Land | Game Boy | 1992 | — |
| Dungeon Magic: Sword of the Elements | Nintendo Entertainment System | 1989 | Winning Entertainment Group |
| Dungeon Master | Super Nintendo Entertainment System, Apple II series | 1987 | FTL Games |
| Dungeon Savior | Game Boy | 2000 | — |
| Dusty Diamond's All-Star Softball | Nintendo Entertainment System | 1989 | Tose Co. |
| Dynamite Bowl | Nintendo Entertainment System | 1987 | Soft Vision International |
| DynamiTracer | Super Nintendo Entertainment System | 1996 | Square |
| Dynasty Warriors VS | Nintendo 3DS | 2012 | — |
| Dynowarz: Destruction of Spondylus | Nintendo Entertainment System | 1990 | Advance Communication |
| Déjà Vu | Nintendo Entertainment System | 1985 | ICOM Simulations |
| Dōkyūsei 2 | Super Nintendo Entertainment System | 1995 | ELF Corporation |
| E-Motion | Game Boy | 1990 | The Assembly Line |
| E.V.O.: Search for Eden | Super Nintendo Entertainment System | 1992 | Givro |
| EA Playground | Wii | 2007 | EA Vancouver |
| EA Sports Active | Wii | 2009 | EA Vancouver |
| EA Sports Active 2 | Wii | 2010 | EA Vancouver |
| EA Sports Active NFL Training Camp | Wii | 2010 | EA Vancouver |
| EA Sports Active: More Workouts | Wii | 2009 | Jędrzej Kitowicz |
| Earth Defense Force | Super Nintendo Entertainment System | 1991 | Jaleco |
| Earth Light | Super Nintendo Entertainment System | 1992 | Hudson Soft |
| EARTH LIGHT LUNA STRIKE | Super Nintendo Entertainment System | 1996 | — |
| Earth Seeker | Wii | 2011 | Crafts & Meister |
| EarthBound | Super Nintendo Entertainment System | 1994 | HAL Laboratory, Creatures |
| EarthBound 64 | Super Nintendo Entertainment System | 2000 | Nintendo |
| EarthBound Halloween Hack | Super Nintendo Entertainment System | 2008 | — |
| Earthworm Jim | Super Nintendo Entertainment System, Game Boy | 1994 | Shiny Entertainment |
| Earthworm Jim 2 | Super Nintendo Entertainment System | 1995 | Shiny Entertainment |
| Earthworm Jim: Menace 2 the Galaxy | Game Boy | 1999 | — |
| Eastward: Octopia | Nintendo 3DS | 2024 | Pixpil |
| Eco Shooter: Plant 530 | Wii | 2009 | Intelligent Systems |
| Ed, Edd n Eddy: The Mis-Edventures | Nintendo GameCube | 2005 | Behaviour Interactive |
| Edo no Kiba | Super Nintendo Entertainment System | 1993 | Riot |
| Eduardo the Samurai Toaster | Wii | 2009 | Semnat Studios |
| Eek! The Cat | Super Nintendo Entertainment System | 1994 | — |
| Egg Mania: Eggstreme Madness | Nintendo GameCube | 2002 | HotGen |
| Eggerland – Revival of the Labyrinth | Nintendo Entertainment System | 1988 | HAL Laboratory |
| Egypt | Nintendo Entertainment System | 1991 | Human Entertainment |
| Eisei Meijin VI | Nintendo GameCube | 2002 | Konami |
| El Chavo | Wii | 2012 | Kaxan Games |
| Elebits | Wii | 2006 | Konami |
| Elevator Action | Nintendo Entertainment System, Game Boy | 1983 | Taito |
| Elfaria | Super Nintendo Entertainment System | 1993 | Hudson Soft, Red Entertainment |
| Elfaria II: The Quest of the Meld | Super Nintendo Entertainment System | 1995 | — |
| Eliminator Boat Duel | Nintendo Entertainment System | 1991 | Sculptured Software |
| Elite | Nintendo Entertainment System | 1984 | David Braben, Ian Bell |
| Elite Soccer | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Elite Soccer | Game Boy | 1994 | — |
| Elminage Original | Nintendo 3DS | 2012 | — |
| Emerald Dragon | Super Nintendo Entertainment System | 1995 | Alfa System |
| Emeraldia | Wii | 1993 | Namco |
| Emergency Heroes | Wii | 2008 | Ubisoft Reflections |
| Emergency Mayhem | Wii | 2008 | Supersonic Software |
| Emit | Super Nintendo Entertainment System | 1994 | Koei |
| Emmitt Smith Football | Super Nintendo Entertainment System | 1995 | — |