| Days of Thunder | Nintendo Entertainment System, Game Boy | 1990 | Krome Studios Melbourne, Argonaut Games, Creative Materials, Tiertex Design Studios |
| Daze Before Christmas | Super Nintendo Entertainment System | 1994 | Funcom |
| De Blob | Wii | 2006 | THQ Nordic, Universomo, Ronimo Games, Blue Tongue Entertainment |
| De Blob 2 | Wii | 2011 | Blue Tongue Entertainment |
| Dead Heat Scramble | Game Boy | 1990 | — |
| Dead Names | Game Boy | 2024 | — |
| Dead or Alive: Dimensions | Nintendo 3DS | 2011 | Team Ninja |
| Dead Rising | Wii | 2006 | Capcom |
| Dead Rising: Chop Till You Drop | Wii | 2009 | Tose Co. |
| Dead Space: Extraction | Wii | 2009 | Visceral Games |
| Dead to Rights | Nintendo GameCube | 2002 | Namco |
| Deadeus | Game Boy | 2019 | — |
| Deadliest Catch: Sea of Chaos | Wii | 2010 | Crave Entertainment |
| Deadly Creatures | Wii | 2009 | THQ |
| Deadly Towers | Nintendo Entertainment System | 1986 | Lenar |
| Deal or No Deal | Wii | 2006 | Cat Daddy Games, Imagination Games, Black Lantern Studios, Inc., Vimukti Technologies |
| Deal or No Deal: Special Edition | Wii | 2010 | Mad Monkey Studio |
| Death Jr. II: Root of Evil | Wii | 2006 | Backbone Entertainment |
| Death Race | Nintendo Entertainment System | 1990 | — |
| Deathbots | Nintendo Entertainment System | 1990 | Odyssey Software |
| Deca Sports | Wii | 2008 | Hudson Soft |
| Deca Sports 2 | Wii | 2009 | Hudson Soft |
| Deca Sports 3 | Wii | 2010 | Hudson Soft |
| Deca Sports Extreme | Nintendo 3DS | 2011 | Hudson Soft |
| Decathlon | Nintendo Entertainment System | 1992 | C&E |
| Dedede's Drum Dash Deluxe | Nintendo 3DS | 2014 | HAL Laboratory |
| Deep Dungeon III: Yūshi e no Tabi | Nintendo Entertainment System | 1988 | Hummingbird Soft |
| Deep Dungeon IV: Kuro no Yōjutsushi | Nintendo Entertainment System | 1990 | Hummingbird Soft |
| Deer Drive Legends | Nintendo 3DS, Wii | 2012 | Raylight Games |
| Deer hunting king | Nintendo 3DS | 2013 | Arc System Works |
| Def Jam Rapstar | Wii | 2010 | 4mm Games |
| Def Jam Vendetta | Nintendo GameCube | 2003 | Syn Sophia |
| Def Jam: Fight for NY | Nintendo GameCube | 2004 | Syn Sophia |
| Defend Your Castle | Wii | 2008 | XGen Studios |
| Defender | Nintendo GameCube | 1981 | WMS Industries |
| Defender | Nintendo GameCube | 2002 | WMS Industries |
| Defender of the Crown | Nintendo Entertainment System | 1986 | Cinemaware |
| Defenders of Dynatron City | Nintendo Entertainment System | 1992 | Lucasfilm Games |
| Defenders of Law, Inc.: Crime in Willburg | Wii | — | Gameinvest, S.A. |
| Defendin' de Penguin | Wii | 2008 | Hijinx Studios, Brain Toys |
| Dekitate High School | Super Nintendo Entertainment System | 1995 | — |
| Dementium Remastered | Nintendo 3DS | 2015 | — |
| Demolition Man | Super Nintendo Entertainment System | 1994 | Virgin Interactive, Acclaim Entertainment |
| Demon Sword | Nintendo Entertainment System | 1988 | Tose Co. |
| Demon's Crest | Super Nintendo Entertainment System | 1994 | Capcom |
| Denjinmakai | Super Nintendo Entertainment System | 1993 | Winkysoft |
| Dennis the Menace | Super Nintendo Entertainment System | 1993 | Ocean Software |
| Desert Commander | Nintendo Entertainment System | 1988 | Kemco |
| Desert Strike | Super Nintendo Entertainment System, Game Boy | 1992 | Electronic Arts |
| Despicable Me: The Game | Wii | 2010 | Vicious Cycle Software |
| Destination Earthstar | Nintendo Entertainment System | 1990 | Imagineering |
| Destiny of an Emperor | Nintendo Entertainment System | 1989 | Capcom |
| Destroy All Humans! Big Willy Unleashed | Wii | 2008 | Locomotive Games |
| Detective Conan: Marionette Symphony | Nintendo 3DS | 2013 | Spike Chunsoft |
| Detective Conan: Phantom Rhapsody | Nintendo 3DS | 2014 | Spike Chunsoft |
| Detective Conan: The Suspicious Gorgeous Train | Game Boy | 1998 | Tom Create |
| Detective Pikachu | Nintendo 3DS | 2018 | Creatures |
| Devil Summoner: Soul Hackers | Nintendo 3DS | 1997 | Atlus |
| Devil World | Nintendo Entertainment System | 1984 | Nintendo |
| Dewy's Adventure | Wii | 2007 | Konami |