| Cyraid | Game Boy | 1990 | — |
| D-Force | Super Nintendo Entertainment System | 1991 | Asmik Ace Entertainment |
| D-Pad Hero | Nintendo Entertainment System | 2009 | Destructoid |
| Daedalian Opus | Game Boy | 1990 | Tokai Communications |
| Daffy Duck | Game Boy | 1994 | Sunsoft |
| Daffy Duck: The Marvin Missions | Super Nintendo Entertainment System | 1994 | ICOM Simulations |
| Daibakushou!! Jinsei Gekijou | Super Nintendo Entertainment System | 1992 | — |
| Daibakushou!! Jinsei Gekijou: Dokidoki Seishun Hen | Super Nintendo Entertainment System | 1993 | — |
| Daibakushou!! Jinsei Gekijou: Ooedo Nikki | Super Nintendo Entertainment System | 1994 | — |
| Daibakushou!! Jinsei Gekijou: Zukkoke Salaryman Hen | Super Nintendo Entertainment System | 1995 | — |
| Daikaijuu Battle: Ultra Coliseum | Wii | 2008 | Bandai Namco Entertainment |
| Daikaijū Monogatari | Super Nintendo Entertainment System | 1994 | Birthday |
| Daikaijū Monogatari II | Super Nintendo Entertainment System | 1996 | Birthday |
| Daisenryaku | Nintendo Entertainment System | 1988 | Quest |
| Daisenryaku | Super Nintendo Entertainment System | 1991 | Sega, Genki, SystemSoft Alpha |
| Daisy Fuentes Pilates | Wii | 2009 | Collision Studios |
| Daiva Story 6: Imperial of Nirsartia | Nintendo Entertainment System | 1986 | D Wonderland Inc. |
| Dakar 2: The World's Ultimate Rally | Nintendo GameCube | 2003 | Acclaim Studios London |
| Danball Senki Wars | Nintendo 3DS | 2013 | Level-5 |
| Dance Aerobics | Nintendo Entertainment System | 1987 | Human Entertainment |
| Dance Dance Revolution | Wii | 2010 | Konami |
| Dance Dance Revolution Disney Grooves | Wii | 2009 | Konami |
| Dance Dance Revolution Hottest Party | Wii | 2007 | Konami |
| Dance Dance Revolution Hottest Party 2 | Wii | 2008 | Konami |
| Dance Dance Revolution Hottest Party 3 | Wii | 2009 | Konami |
| Dance Dance Revolution II | Wii | 2011 | Konami |
| Dance Dance Revolution Winx Club | Wii | 2009 | Konami |
| Dance Dance Revolution: Mario Mix | Nintendo GameCube | 2005 | Konami |
| Dance on Broadway | Wii | 2010 | Ubisoft Halifax |
| Dance Sensation! | Wii | 2010 | Alpine Studios |
| Dance! It's Your Stage | Wii | 2010 | Sproing Interactive Media |
| Dancing with the Stars | Wii | 2007 | Zoë Mode |
| Dancing with the Stars: We Dance! | Wii | 2008 | Zoë Mode |
| Dangan GB2 | Game Boy | 2023 | — |
| Dangeresque 3: The Criminal Projective | Wii | 2008 | Telltale Games |
| Dangerous Road | Nintendo 3DS | 2023 | — |
| Danny Sullivan's Indy Heat | Nintendo Entertainment System | 1991 | Leland Corporation |
| Darius | Game Boy | 1987 | Taito |
| Darius Force | Super Nintendo Entertainment System | 1993 | Taito |
| Darius Twin | Super Nintendo Entertainment System | 1991 | Taito |
| Dark Half | Super Nintendo Entertainment System | 1996 | — |
| Dark Kingdom | Super Nintendo Entertainment System | 1994 | — |
| Dark Law: Meaning of Death | Super Nintendo Entertainment System | 1997 | — |
| Dark Lord | Nintendo Entertainment System | 1991 | Data East |
| Dark Summit | Nintendo GameCube | 2001 | Radical Entertainment |
| Darkened Skye | Nintendo GameCube | 2002 | Simon & Schuster, Boston Animation |
| Darkman | Nintendo Entertainment System | 1991 | Painting by Numbers, Ltd. |
| Darkman | Game Boy | 1991 | Ocean Software, Twilight |
| Darkwing Duck | Nintendo Entertainment System, Game Boy | 1992 | Capcom |
| Darts Up 3D | Nintendo 3DS | 2013 | EnjoyUp |
| Dash Galaxy in the Alien Asylum | Nintendo Entertainment System | 1990 | Krome Studios Melbourne |
| Dasshutsu Adventure: Noroi no Sūretsu | Nintendo 3DS | 2015 | Intense Limited |
| Dastardly and Muttley | Game Boy | 1992 | — |
| Data East Arcade Classics | Wii | 2010 | G1M2 |
| Datach | Nintendo Entertainment System | 1992 | Bandai |
| Date Kimiko no Virtual Tennis | Super Nintendo Entertainment System | 1994 | Jorudan |
| Dave Mirra BMX Challenge | Wii | 2006 | Left Field Productions |
| Dave Mirra Freestyle BMX 2 | Nintendo GameCube | 2001 | Underground Development |
| David Crane's Amazing Tennis | Super Nintendo Entertainment System | 1992 | Absolute Entertainment |
| Day Dreamin' Davey | Nintendo Entertainment System | 1992 | Sculptured Software |