| Crash Dummy Vs The Evil D-Troit | Wii | 2007 | Twelve Games |
| Crash Nitro Kart | Nintendo GameCube | 2003 | Blizzard Albany |
| Crash of the Titans | Wii | 2007 | Radical Entertainment |
| Crash Tag Team Racing | Nintendo GameCube | 2005 | Radical Entertainment |
| Crash: Mind over Mutant | Wii | 2008 | Radical Entertainment |
| Crashmo | Nintendo 3DS | 2012 | Intelligent Systems |
| Crayola: Colorful Journey | Wii | 2009 | StudioBlack Games |
| Crayon Shin-chan - Arashi o yobu enji | Super Nintendo Entertainment System | 1993 | — |
| Crayon Shin-chan - Nagagutsu Dobon!! | Super Nintendo Entertainment System | — | Fortyfive |
| Crayon Shin-chan 2 - Dai maō no gyakushū | Super Nintendo Entertainment System | 1994 | — |
| Crayon Shin-Chan: Ora to Poi Poi | Nintendo Entertainment System | 1993 | Tose Co. |
| Crayon Shin-chan: Saikyō Kazoku Kasukabe King Wii | Wii | 2006 | Banpresto |
| Crazy Chicken Tales | Wii | 2009 | Coreplay |
| Crazy Climber | Nintendo Entertainment System, Wii | 1980 | Nichibutsu, Jorudan |
| Crazy Machines | Wii | 2005 | Fakt Software |
| Crazy Taxi | Nintendo GameCube | 1999 | Sega AM3 |
| Create | Wii | 2010 | Electronic Arts |
| Creeping Terror | Nintendo 3DS | 2017 | — |
| Creepy Brawlers | Nintendo Entertainment System | 2017 | Mega Cat Studios |
| Crimson Shroud | Nintendo 3DS | 2012 | Nex Entertainment |
| Crisis Force | Nintendo Entertainment System | 1991 | Konami |
| Critter Round-Up | Wii | 2008 | Epicenter Studios |
| CrossFire | Nintendo Entertainment System | 1990 | Kyugo Trading, Sanritsu Denki |
| Crosswords Plus | Nintendo 3DS | 2012 | Nintendo Software Technology |
| Cruis'n | Wii | 2007 | Kung Fu Factory |
| Cruis'n USA | Wii | 1996 | Midway Games |
| Cruise Ship Vacation Games | Wii | 2009 | Frozen Codebase |
| Crystal Beans: From Dungeon Explorer | Super Nintendo Entertainment System | 1995 | — |
| Crystal Defenders | Wii | 2008 | Square Enix |
| Crystal Mines | Nintendo Entertainment System | 1989 | Color Dreams |
| Crystal Warriors | Nintendo 3DS | 1991 | Sega |
| Crystalis | Nintendo Entertainment System | 1990 | SNK |
| Crystareino | Nintendo 3DS | 2014 | — |
| CSI: Deadly Intent | Wii | 2009 | Telltale Games, Other Ocean |
| CSI: Fatal Conspiracy | Wii | 2010 | Telltale Games |
| CSI: Hard Evidence | Wii | 2007 | Telltale Games, Findev |
| Cube Creator 3D | Nintendo 3DS | 2015 | Big John Games |
| Cubello | Wii | 2008 | skip Ltd. |
| Cubic Ninja | Nintendo 3DS | 2011 | AQ Interactive |
| Cubivore: Survival of the Fittest | Nintendo GameCube | 2002 | Saru Brunei |
| Cubix Robots for Everyone: Showdown | Nintendo GameCube | 2003 | Blitz Games |
| Culdcept Revolt | Nintendo 3DS | 2016 | — |
| Cult County | Nintendo 3DS | — | Renegade Kid |
| Cult Jump | Game Boy | 1993 | — |
| Curious George | Nintendo GameCube | 2006 | Monkey Bar Games |
| Curling Super Championship | Nintendo 3DS | 2012 | Cypronia |
| Cursed Mountain | Wii | 2009 | Deep Silver Vienna |
| Custom Robo | Nintendo GameCube | 2004 | Noise |
| Cut the Rope | Nintendo 3DS | 2011 | ZeptoLab, Abstraction Games |
| Cut the Rope: Triple Treat | Nintendo 3DS | — | ZeptoLab |
| Cutthroat Island | Super Nintendo Entertainment System, Game Boy | 1995 | Software Creations |
| Cyber Citizen Shockman Zero | Super Nintendo Entertainment System | 1997 | Masaya |
| Cyber Knight | Super Nintendo Entertainment System | 1992 | Group SNE |
| Cyber Knight II: Chikyū Teikoku no Yabō | Super Nintendo Entertainment System | 1994 | — |
| Cyber Spin | Super Nintendo Entertainment System | 1992 | Arc System Works |
| Cyberball | Nintendo Entertainment System | 1988 | Atari Games |
| Cyberbike | Wii | 2010 | Eko Software |
| Cybernoid | Nintendo Entertainment System | 1989 | Raffaele Cecco |
| Cyborg 009 | Super Nintendo Entertainment System | 1993 | Riot Games |
| Cycle Race: Road Man | Nintendo Entertainment System | 1988 | Advance Communication |