| Code Lyoko: Quest for Infinity | Wii | 2007 | Neko Entertainment |
| Code Name: S.T.E.A.M. | Nintendo 3DS | 2015 | Intelligent Systems |
| Code Name: Viper | Nintendo Entertainment System | 1990 | Capcom, Arc System Works |
| Code of Princess | Nintendo 3DS | 2012 | Bones |
| Codename: Kids Next Door – Operation: V.I.D.E.O.G.A.M.E. | Nintendo GameCube | 2005 | High Voltage Software |
| Cold Stone Creamery: Scoop It Up | Wii | 2009 | CyberPlanet Interactive |
| Colin McRae: Dirt 2 | Wii | 2009 | Codemasters |
| College Slam | Super Nintendo Entertainment System | 1996 | Acclaim Studios Austin |
| Color a Dinosaur | Nintendo Entertainment System | 1993 | FarSight Studios |
| Color Zen | Nintendo 3DS, Wii | 2013 | Cypronia, Large Animal Games |
| Color Zen Kids | Nintendo 3DS | 2014 | Cypronia, Large Animal Games |
| Colorful Dragon | Nintendo Entertainment System | — | Thin Chen Enterprise |
| ColorZ | Wii | 2009 | Exkee |
| Columns | Super Nintendo Entertainment System | 1990 | Sega |
| Combat of Giants: Dinosaurs 3D | Nintendo 3DS | 2011 | Ubisoft Quebec |
| Combat of Giants: Dinosaurs Strike | Wii | 2010 | Ubisoft Quebec |
| Commando | Nintendo Entertainment System | 1985 | Capcom |
| Computer Nouryoku Kaiseki: Ultra Baken | Super Nintendo Entertainment System | 1995 | Culture Brain |
| Conan | Nintendo GameCube | 2004 | Cauldron |
| Conan: The Mysteries of Time | Nintendo Entertainment System | 1991 | System 3, Mindscape |
| Conception 2: Children of the Seven Stars | PlayStation Vita, Nintendo 3DS | 2013 | Spike Chunsoft |
| Conduit 2 | Wii | 2011 | High Voltage Software |
| Conflict | Nintendo Entertainment System | 1989 | Tokai Communications |
| Conflict: Desert Storm | Nintendo GameCube | 2002 | Pivotal Games |
| Conflict: Desert Storm II | Nintendo GameCube | 2003 | Pivotal Games |
| Congo's Caper | Super Nintendo Entertainment System | 1992 | Data East |
| Conker's Other Bad Fur Day | Nintendo GameCube | — | Rare Ltd. |
| Conquest of the Crystal Palace | Nintendo Entertainment System | 1990 | Quest |
| Contra | Nintendo Entertainment System | 1987 | Konami |
| Contra Force | Nintendo Entertainment System | 1992 | Konami |
| Contra III: The Alien Wars | Super Nintendo Entertainment System, Game Boy | 1992 | Konami |
| Contra ReBirth | Wii | 2009 | M2 |
| Cook Wars | Wii | 2009 | Virtual Toys |
| Cooking Mama 4: Kitchen Magic | Nintendo 3DS | 2011 | Cooking Mama Limited |
| Cooking Mama 5: Bon Appétit! | Nintendo 3DS | 2013 | Cooking Mama Limited |
| Cooking Mama: Cook Off | Wii | 2007 | Cooking Mama Limited |
| Cooking Mama: Sweet Shop | Nintendo 3DS | 2014 | Office Create |
| Cooking Mama: World Kitchen | Wii | 2008 | Cooking Mama Limited |
| Cool Spot | Super Nintendo Entertainment System, Game Boy | 1993 | Virgin Interactive |
| Cool World | Game Boy | 1992 | Twilight |
| Cool World | Nintendo Entertainment System | 1993 | Ocean Software |
| Cool World | Super Nintendo Entertainment System | 1993 | — |
| Coraline | Wii | 2009 | Papaya Studio |
| Coron Land | Super Nintendo Entertainment System | 1995 | — |
| Corpse Party: Blood Covered Repeated Fear | Nintendo 3DS | 2010 | — |
| Cosmic Epsilon | Nintendo Entertainment System | 1989 | Magical Company |
| Cosmic Family | Wii | 2007 | Ubisoft |
| Cosmic Wars | Nintendo Entertainment System | 1989 | Konami |
| Cosmo Gang the Puzzle | Super Nintendo Entertainment System, Wii | 1992 | Namco |
| Cosmo Gang the Video | Super Nintendo Entertainment System | 1992 | Namco |
| Cosmo Police Galivan | Nintendo Entertainment System | 1988 | Nichibutsu |
| Cosmo Police Galivan II: Arrow of Justice | Super Nintendo Entertainment System | 1993 | — |
| Cosmo Tank | Game Boy | 1990 | — |
| Counter Force | Wii | 2007 | HyperDevbox Japan |
| Cowboy Kid | Nintendo Entertainment System | 1991 | Daisuke Amaya |
| Crackout | Nintendo Entertainment System | 1986 | Konami |
| Cradle of Rome | Wii | 2008 | Awem |
| Cranium Kabookii | Wii | 2007 | Ubisoft Quebec |
| Crash 'n' the Boys: Street Challenge | Nintendo Entertainment System, Game Boy, Nintendo 3DS | 1992 | Technōs Japan |
| Crash Bandicoot: The Wrath of Cortex | Nintendo GameCube | 2001 | Traveller's Tales |