| Castlevania | Nintendo Entertainment System | 1986 | Konami |
| Castlevania II: Belmont's Revenge | Game Boy | 1991 | Konami |
| Castlevania II: Simon's Quest | Nintendo Entertainment System | 1987 | Konami |
| Castlevania III: Dracula's Curse | Nintendo Entertainment System | 1989 | Konami |
| Castlevania Judgment | Wii | 2008 | Eighting |
| Castlevania Legends | Game Boy | 1997 | Konami |
| Castlevania: Dracula X | Super Nintendo Entertainment System | 1995 | Konami |
| Castlevania: Lords of Shadow – Mirror of Fate | Nintendo 3DS | 2013 | MercurySteam |
| Castlevania: Rondo of Blood | Super Nintendo Entertainment System, Wii | 1993 | Konami |
| Castlevania: The Adventure | Game Boy | 1989 | Konami |
| Castlevania: The Adventure ReBirth | Wii | 2009 | M2 |
| Castleween | Nintendo GameCube | 2002 | Kalisto Entertainment |
| Cate West: The Vanishing Files | Wii | 2008 | Gamenauts |
| Catrap | Game Boy | 1990 | Asmik Ace Entertainment |
| Catwoman | Nintendo GameCube | 2004 | Magic Pockets |
| Cave Noire | Game Boy | 1991 | Konami |
| Cave Story | Nintendo 3DS, Wii | 2004 | Daisuke Amaya |
| Cave Story 3D | Nintendo 3DS | — | Nicalis |
| Caveman Ughlympics | Nintendo Entertainment System | 1988 | Dynamix |
| CB Chara Wars: Ushinawareta Gag | Super Nintendo Entertainment System | 1992 | — |
| Cel Damage | Nintendo GameCube | 2001 | Pseudo Interactive |
| Celebrity Sports Showdown | Wii | 2008 | EA Vancouver |
| Centipede | Game Boy, PlayStation Vita | 1981 | Atari, Inc. |
| Centipede: Infestation | Nintendo 3DS, Wii | 2011 | WayForward Technologies |
| Chack'n Pop | Nintendo Entertainment System | 1983 | Taito |
| Challenge of the Dragon | Nintendo Entertainment System | 1990 | Color Dreams |
| Challenger | Nintendo Entertainment System | 1985 | Hudson Soft |
| Chalvo 55 | Game Boy | 1997 | — |
| Champion Jockey: G1 Jockey & Gallop Racer | Wii | 2011 | Koei |
| Champions World Class Soccer | Super Nintendo Entertainment System | 1993 | Park Place Productions |
| Championship Bowling | Nintendo Entertainment System | 1989 | Athena |
| Championship Foosball | Wii | 2008 | 505 Games |
| Championship Lode Runner | Nintendo Entertainment System | 1985 | Hudson Soft |
| Championship Pool | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1993 | Bitmasters |
| Championship Rally | Nintendo Entertainment System | 1991 | Human Entertainment |
| Changeable Guardian Estique | Nintendo Entertainment System | 2024 | — |
| Chaos Field | Nintendo GameCube | 2004 | Milestone |
| Chaos Seed | Super Nintendo Entertainment System | 1996 | Neverland |
| Chaos World | Nintendo Entertainment System | 1991 | Winning Entertainment Group |
| Chaotic: Shadow Warriors | Wii | 2009 | — |
| Charinko Hero | Nintendo GameCube | 2003 | Banpresto |
| Charlie and the Chocolate Factory | Nintendo GameCube | 2005 | High Voltage Software |
| Charlie's Angels | Nintendo GameCube | 2003 | Neko Entertainment |
| Charm Girls Club: Pajama Party | Wii | 2009 | Electronic Arts |
| Chase H.Q. | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy, Wii | 1988 | Taito |
| Chase: Cold Case Investigations – Distant Memories | Nintendo 3DS | 2016 | Arc System Works |
| Check vs. Mate | Wii | 2011 | Targem Games |
| Cheetahmen II | Nintendo Entertainment System | — | Active Enterprises |
| Cheggers Party Quiz | Wii | 2007 | Oxygen Games |
| Chess Crusade | Wii | 2008 | Slam Games |
| Chester Cheetah: Too Cool to Fool | Super Nintendo Entertainment System | 1992 | Kaneko |
| Chester Cheetah: Wild Wild Quest | Super Nintendo Entertainment System | 1993 | Kaneko |
| Chevrolet Camaro: Wild Ride | Nintendo 3DS, Wii | 2010 | Visual Impact |
| Chibi Devi! | Nintendo 3DS | 2012 | Alchemist |
| Chibi Maruko-chan: Harikiri 365-Nichi no Maki | Super Nintendo Entertainment System | 1991 | — |
| Chibi Maruko-chan: Mezase! Minami no Island!! | Super Nintendo Entertainment System | 1995 | Konami |
| Chibi-Robo! | Nintendo GameCube, Wii | 2006 | skip Ltd. |
| Chibi-Robo! Photo Finder | Nintendo 3DS | 2013 | skip Ltd. |
| Chibi-Robo! Zip Lash | Nintendo 3DS | 2015 | — |
| Chick Chick Boom | Wii | 2007 | Extra Toxic |