| SpongeBob SquarePants: Revenge of the Flying Dutchman | Nintendo GameCube | 2002 | Blizzard Albany |
| SpongeBob SquigglePants | Nintendo 3DS, Wii | 2011 | WayForward Technologies |
| SpongeBob's Atlantis SquarePantis | Wii | 2007 | Blitz Games |
| SpongeBob's Boating Bash | Wii | 2010 | Firebrand Games |
| SpongeBob's Truth or Square | Wii | 2009 | Heavy Iron Studios |
| Spore Hero | Wii | 2009 | EA Montreal |
| Sports Collection | Game Boy | 1996 | Tose Co. |
| Sports Illustrated: Championship Football & Baseball | Super Nintendo Entertainment System | 1993 | Malibu Comics |
| Sports Island 3D | Nintendo 3DS | 2011 | — |
| Spot: The Cool Adventure | Game Boy | 1994 | Visual Concepts |
| Spot: The Video Game | Nintendo Entertainment System, Game Boy | 1990 | Visual Concepts, Virgin Interactive |
| SPRay | Wii | 2008 | Eko Software |
| Spriggan Powered | Super Nintendo Entertainment System | 1996 | Micronics |
| Springdale: Riding Adventures | Wii | 2010 | Pixel Tales, Hidden Entertainment |
| Sprinter Monogatari: Mezase!! Ikkaku Senkin | Super Nintendo Entertainment System | 1995 | VAP Inc. |
| Spud's Adventure | Game Boy | 1991 | Atlus |
| Spy Fox in "Dry Cereal" | Wii | 1997 | Humongous Entertainment |
| Spy Games: Elevator Mission | Wii | 2007 | Dreams Co., Ltd. |
| Spy Hunter | Nintendo Entertainment System, Nintendo GameCube | 1983 | Midway Games |
| Spy Hunter | Nintendo GameCube | 2001 | Paradigm Entertainment |
| Spy Hunter | PlayStation Vita, Nintendo 3DS | 2012 | TT Fusion |
| Spy vs. Spy | Nintendo Entertainment System, Game Boy | 1984 | Aackosoft, First Star Software |
| Spy vs. Spy: The Island Caper | Nintendo Entertainment System | 1985 | Aackosoft |
| Spyborgs | Wii | 2009 | Bionic Games |
| Spyro: A Hero's Tail | Nintendo GameCube | 2004 | Eurocom |
| Spyro: Enter the Dragonfly | Nintendo GameCube | 2002 | — |
| Sqoon | Nintendo Entertainment System | 1986 | Magical Company |
| Square Deal: The Game of Two Dimensional Poker | Nintendo Entertainment System, Game Boy | 1990 | Human Engineered Software, Hect |
| Square's Tom Sawyer | Nintendo Entertainment System | 1989 | Square |
| Squids Odyssey | Nintendo 3DS | 2014 | The Game Bakers |
| SSX 3 | Nintendo GameCube | 2003 | EA Vancouver |
| SSX Blur | Wii | 2007 | EA Montreal |
| SSX On Tour | Nintendo GameCube | 2005 | EA Vancouver |
| SSX Tricky | Nintendo GameCube | 2001 | EA Vancouver |
| St Andrews: Eikō to Rekishi no Old Course | Super Nintendo Entertainment System | 1995 | — |
| Stack-Up | Nintendo Entertainment System | 1985 | Nintendo Research & Development 1 |
| Stadium Events | Nintendo Entertainment System | 1986 | Bandai |
| Stanley: The Search for Dr. Livingston | Nintendo Entertainment System | 1992 | Sculptured Software |
| Star Force | Nintendo Entertainment System | 1984 | Koei Tecmo Holdings |
| Star Fox | Super Nintendo Entertainment System | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| Star Fox 2 | Super Nintendo Entertainment System | 2017 | Nintendo |
| Star Fox 64 | Wii | 1997 | Nintendo Entertainment Analysis & Development |
| Star Fox 64 3D | Nintendo 3DS | 2011 | Q-Games, Nintendo Entertainment Analysis & Development |
| Star Fox Adventures | Nintendo GameCube | 2002 | Rare Ltd. |
| Star Fox: Assault | Nintendo GameCube | 2005 | Bandai Namco Entertainment |
| Star Fox: Super Weekend | Super Nintendo Entertainment System | 1993 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| Star Luster | Nintendo Entertainment System | 1985 | Namco |
| Star Ocean | Super Nintendo Entertainment System | 1996 | tri-Ace |
| Star Soldier | Nintendo Entertainment System | 1986 | Hudson Soft |
| Star Trek Prodigy: Supernova | Game Boy | 2022 | Tessera Studios |
| Star Trek: 25th Anniversary | Nintendo Entertainment System | 1991 | Interplay Entertainment |
| Star Trek: 25th Anniversary | Game Boy | 1992 | Visual Concepts |
| Star Trek: Conquest | Wii | 2007 | 4J Studios |
| Star Trek: Deep Space Nine – Crossroads of Time | Super Nintendo Entertainment System | 1995 | Appaloosa Interactive |
| Star Trek: Starfleet Academy – Starship Bridge Simulator | Super Nintendo Entertainment System | 1994 | High Voltage Software |
| Star Trek: Tactical Assault | Game Boy | 2006 | Quicksilver Software |
| Star Trek: The Next Generation | Nintendo Entertainment System, Game Boy | 1993 | Absolute Entertainment |
| Star Trek: The Next Generation: Future's Past | Super Nintendo Entertainment System | 1994 | Spectrum HoloByte |
| Star Voyager | Nintendo Entertainment System | 1986 | ASCII Corporation |
| Star Wars | Nintendo Entertainment System | 1987 | Namco |