| Soccer Mania | Game Boy | 1990 | — |
| Socks the Cat Rocks the Hill | Super Nintendo Entertainment System | 1993 | Kaneko |
| Solar Jetman | Nintendo Entertainment System | 1990 | Zippo Games |
| Solar Striker | Game Boy | 1990 | Nintendo Research & Development 1 |
| Soldam | Game Boy | 1992 | Jaleco |
| Solid Runner | Super Nintendo Entertainment System | 1997 | Sting |
| Solomon's Club | Game Boy | 1991 | — |
| Solomon's Key | Nintendo Entertainment System | 1986 | Tecmo |
| Solomon's Key 2 | Nintendo Entertainment System | 1992 | Tecmo |
| Solstice | Nintendo Entertainment System | 1990 | Software Creations |
| Solvalou | Wii | 1991 | Namco |
| Somari | Nintendo Entertainment System | 1994 | Hummer Team, Dendy |
| Song Master | Super Nintendo Entertainment System | 1992 | Japan Art Media |
| Sonic & All-Stars Racing Transformed | PlayStation Vita, Nintendo 3DS | 2012 | Sumo Digital |
| Sonic & Knuckles | Nintendo GameCube, Wii | 1994 | Sonic Team |
| Sonic & Sega All-Stars Racing | Wii | 2010 | Sumo Digital |
| Sonic 3 & Knuckles | Nintendo GameCube | 1994 | Sonic Team |
| Sonic Adventure | Nintendo GameCube | 1998 | Sonic Team, Now Production |
| Sonic Adventure 2 | Nintendo GameCube | 2001 | Sonic Team |
| Sonic Adventure 2: Battle | Nintendo GameCube | 2002 | Sonic Team |
| Sonic Adventure DX: Director's Cut | Nintendo GameCube | 2003 | Sonic Team |
| Sonic and the Black Knight | Wii | 2009 | Sonic Team |
| Sonic and the Secret Rings | Wii | 2007 | Sonic Team |
| Sonic Blast Man | Super Nintendo Entertainment System | 1992 | Taito |
| Sonic Blast Man II | Super Nintendo Entertainment System | 1994 | — |
| Sonic Boom | Nintendo 3DS | 2014 | — |
| Sonic Boom: Fire & Ice | Nintendo 3DS | 2016 | Sanzaru Games |
| Sonic Boom: Shattered Crystal | Nintendo 3DS | 2014 | Sanzaru Games |
| Sonic Colors | Wii | 2010 | Sonic Team |
| Sonic Gems Collection | Nintendo GameCube | 2005 | Sonic Team |
| Sonic Generations | Nintendo 3DS | 2011 | Sonic Team, Dimps |
| Sonic Heroes | Nintendo GameCube | 2003 | Sonic Team |
| Sonic Lost World | Nintendo 3DS | 2013 | Sonic Team |
| Sonic Mega Collection | Nintendo GameCube | 2002 | Sonic Team |
| Sonic Riders | Nintendo GameCube | 2006 | Sonic Team |
| Sonic Riders: Zero Gravity | Wii | 2008 | Sonic Team |
| Sonic the Fighters | Nintendo GameCube | 1996 | Sega AM2 |
| Sonic the Hedgehog | Nintendo GameCube, Nintendo 3DS, Wii | 1991 | Sonic Team, Konami |
| Sonic the Hedgehog 2 | Nintendo GameCube, Nintendo 3DS | 1992 | Sonic Team |
| Sonic the Hedgehog 3 | Nintendo 3DS | 1994 | Sonic Team |
| Sonic the Hedgehog 4 | Super Nintendo Entertainment System | 1996 | — |
| Sonic the Hedgehog 4: Episode I | Wii | 2010 | Sonic Team |
| Sonic the Hedgehog CD | Nintendo GameCube | 1993 | Sonic Team |
| Sonic Unleashed | Wii | 2008 | Sonic Team |
| SonSon | Nintendo Entertainment System | 1984 | Capcom |
| Sorcerian | Wii | 1987 | Aeria, Nihon Falcom, Sega, G-Mode |
| Sorcery Blade | Wii | 2008 | WorldWideSoftware |
| Soreyuke Ebisumaru Karakuri: Meiro Kieta Goemon no Nazo | Super Nintendo Entertainment System | 1996 | — |
| SOS | Super Nintendo Entertainment System | 1993 | Human Entertainment |
| Sougou Kakutougi Rings: Astral Bout 3 | Super Nintendo Entertainment System | 1995 | — |
| Sougou Kakutougi: Astral Bout 2 - The Total Fighters | Super Nintendo Entertainment System | 1994 | — |
| Soukou Kihei Votoms: The Battling Road | Super Nintendo Entertainment System | 1993 | — |
| Soul & Sword | Super Nintendo Entertainment System | 1993 | — |
| Soul Blazer | Super Nintendo Entertainment System | 1992 | Quintet |
| Soul Eater: Monotone Princess | Wii | 2008 | Square Enix |
| Soulcalibur II | Nintendo GameCube | 2002 | Project Soul |
| Soulcalibur Legends | Wii | 2007 | Project Soul |
| Sound Fantasy | Super Nintendo Entertainment System | — | Nintendo |
| Sound Novel Tsukūru | Super Nintendo Entertainment System | 1996 | Success, ASCII Corporation |
| Space Ace | Super Nintendo Entertainment System | 1984 | RDI Video Systems |