| Style Savvy: Fashion Forward | Nintendo 3DS | 2015 | Syn Sophia |
| Style Savvy: Styling Star | Nintendo 3DS | 2017 | Syn Sophia |
| Style Savvy: Trendsetters | Nintendo 3DS | 2012 | Syn Sophia |
| Sudoku Challenge! | Wii | 2008 | Digital Leisure |
| Sudokuball Detective | Wii | 2009 | White Bear BV, CreaVate |
| Sugoi Hebereke | Super Nintendo Entertainment System | 1994 | Sunsoft, OLM, Inc. |
| Sugoro Quest++: Dicenics | Super Nintendo Entertainment System | 1994 | — |
| Sugoro Quest: Dice Heroes | Nintendo Entertainment System | 1991 | Technōs Japan |
| Sugoroku Ginga Senki | Super Nintendo Entertainment System | 1996 | Bottom Up |
| Sukeban Shachou Rena | Wii | 2009 | Jorudan |
| Summer Athletics | Wii | 2008 | 49Games |
| Summer Athletics 2009 | Wii | 2009 | 49Games |
| Summer Sports: Paradise Island | Wii | 2008 | Destineer |
| Summoner 2 | Nintendo GameCube | 2002 | Volition |
| Sumo Fighter: Tōkaidō Basho | Game Boy | 1991 | KID |
| Sunday Funday | Nintendo Entertainment System | 1995 | Color Dreams |
| Sunman | Nintendo Entertainment System | 1992 | EIM |
| Sunny Garcia Surfing | Nintendo GameCube | 2001 | Krome Studios |
| Sunset Riders | Super Nintendo Entertainment System | 1991 | Konami |
| Sunsoft Grand Prix | Game Boy | 1990 | — |
| Super 3D Noah's Ark | Super Nintendo Entertainment System | 1994 | Wisdom Tree |
| Super Adventure Island | Super Nintendo Entertainment System | 1992 | Produce! |
| Super Adventure Island II | Super Nintendo Entertainment System | 1994 | Hudson Soft |
| Super Air Diver | Super Nintendo Entertainment System | 1993 | — |
| Super Back to the Future Part II | Super Nintendo Entertainment System | 1993 | GameFAQs |
| Super Baseball Simulator 1.000 | Super Nintendo Entertainment System | 1991 | Culture Brain |
| Super Bases Loaded | Super Nintendo Entertainment System | 1991 | Tose Co. |
| Super Bases Loaded 2 | Super Nintendo Entertainment System | 1993 | Tose Co. |
| Super Bases Loaded 3 | Super Nintendo Entertainment System | 1994 | Tose Co. |
| Super Batter Up | Super Nintendo Entertainment System | 1992 | — |
| Super Battleship | Super Nintendo Entertainment System | 1993 | — |
| Super Battletank | Super Nintendo Entertainment System | 1992 | Imagineering |
| Super Battletank 2 | Super Nintendo Entertainment System | 1994 | Imagineering |
| Super Bikkuriman | Super Nintendo Entertainment System | 1993 | Bandai |
| Super Birdie Rush | Super Nintendo Entertainment System | 1992 | — |
| Super Bomberman | Super Nintendo Entertainment System | 1993 | Hudson Soft |
| Super Bomberman 2 | Super Nintendo Entertainment System | 1994 | Hudson Soft |
| Super Bomberman 3 | Super Nintendo Entertainment System | 1995 | Hudson Soft |
| Super Bomberman 4 | Super Nintendo Entertainment System | 1996 | Produce! |
| Super Bomberman 5 | Super Nintendo Entertainment System | 1997 | Hudson Soft |
| Super Bomberman: Panic Bomber W | Super Nintendo Entertainment System | 1995 | — |
| Super Bombliss | Super Nintendo Entertainment System, Game Boy | 1995 | — |
| Super Bonk | Super Nintendo Entertainment System | 1994 | Red Entertainment |
| Super Bowling | Super Nintendo Entertainment System | 1992 | KID |
| Super Bubble Pop | Nintendo GameCube | 2002 | Zombie Studios |
| Super Buster Bros. | Super Nintendo Entertainment System | 1990 | Capcom |
| Super Caesars Palace | Super Nintendo Entertainment System | 1993 | Majesco Entertainment |
| Super Cars | Nintendo Entertainment System | 1990 | Gremlin Interactive |
| Super Casino 2 | Super Nintendo Entertainment System | 1994 | — |
| Super Castlevania IV | Super Nintendo Entertainment System | 1991 | Konami |
| Super Chase H.Q. | Super Nintendo Entertainment System | 1992 | Taito |
| Super Chinese 3 | Nintendo Entertainment System | 1991 | Culture Brain |
| Super Chinese Fighter | Super Nintendo Entertainment System | 1995 | Culture Brain |
| Super Chinese Fighter GB | Game Boy | 1996 | Culture Brain |
| Super Chinese Land 1-2-3 Dash | Game Boy | 1995 | Culture Brain |
| Super Chinese Land 3 | Game Boy | 1995 | Culture Brain |
| Super Chinese World 2 | Super Nintendo Entertainment System | 1993 | Culture Brain |
| Super Chinese World 3 | Super Nintendo Entertainment System | 1995 | Culture Brain |
| Super Conflict | Super Nintendo Entertainment System | 1993 | EA Seattle |
| Super Contra | Nintendo Entertainment System | 1988 | Konami |