| Star Wars | Nintendo Entertainment System, Game Boy | 1991 | Lucasfilm Games, Krome Studios Melbourne, NMS Software, Tiertex Design Studios |
| Star Wars Jedi Knight II: Jedi Outcast | Nintendo GameCube | 2002 | Raven Software |
| Star Wars Rogue Squadron II: Rogue Leader | Nintendo GameCube | 2001 | Factor 5 |
| Star Wars Rogue Squadron III: Rebel Strike | Nintendo GameCube | 2003 | Factor 5 |
| Star Wars: Bounty Hunter | Nintendo GameCube | 2002 | Lucasfilm Games |
| Star Wars: The Clone Wars | Nintendo GameCube | 2002 | Pandemic Studios |
| Star Wars: The Clone Wars – Lightsaber Duels | Wii | 2008 | Krome Studios |
| Star Wars: The Clone Wars – Republic Heroes | Wii | 2009 | Krome Studios |
| Star Wars: The Empire Strikes Back | Nintendo Entertainment System, Game Boy | 1992 | Lucasfilm Games, Sculptured Software |
| Star Wars: The Force Unleashed | Wii | 2008 | Lucasfilm Games |
| Star Wars: The Force Unleashed II | Wii | 2010 | Lucasfilm Games |
| Stardew Valley | PlayStation Vita, Nintendo 3DS | 2016 | ConcernedApe LLC, Eric Barone |
| Stargate | Super Nintendo Entertainment System | 1994 | Acclaim Studios London |
| Stargate | Nintendo Entertainment System | 1981 | Vid Kidz |
| Stargate | Game Boy | 1994 | — |
| Starship Hector | Nintendo Entertainment System | 1987 | Hudson Soft |
| Starsky & Hutch | Nintendo GameCube | 2003 | Mind's Eye Productions |
| Starsweep | Game Boy | 1997 | — |
| StarTropics | Nintendo Entertainment System | 1990 | Nintendo Integrated Research & Development |
| Stealth | Super Nintendo Entertainment System | 1992 | — |
| Stealth ATF | Nintendo Entertainment System | 1989 | Imagineering |
| SteamWorld Dig | PlayStation Vita, Nintendo 3DS | 2013 | Image & Form |
| SteamWorld Dig 2 | Nintendo 3DS | 2017 | Image & Form |
| SteamWorld Heist | PlayStation Vita, Nintendo 3DS | 2015 | Image & Form |
| Steel Diver | Nintendo 3DS | 2011 | Nintendo Entertainment Analysis & Development |
| Steel Diver: Sub Wars | Nintendo 3DS | 2014 | Nintendo |
| Steel Talons | Super Nintendo Entertainment System | 1991 | Atari Games |
| Stella Glow | Nintendo 3DS | 2015 | Imageepoch |
| Sterling Sharpe: End 2 End | Super Nintendo Entertainment System | 1995 | Tose Co. |
| Stinger | Nintendo Entertainment System | 1986 | Konami |
| Stone Protectors | Super Nintendo Entertainment System | 1994 | Eurocom |
| Stop That Roach! | Game Boy | 1994 | — |
| Storm Chaser: Tornado Alley | Game Boy, Nintendo 3DS | 2018 | Skunk Software |
| Story of Seasons | Nintendo 3DS | 2014 | Marvelous |
| Story of Seasons: Trio of Towns | Nintendo 3DS | 2016 | Marvelous |
| Streemerz | Nintendo Entertainment System | 2010 | — |
| Street Cop | Nintendo Entertainment System | 1987 | Human Entertainment |
| Street Fighter 2010: The Final Fight | Nintendo Entertainment System, Nintendo 3DS | 1990 | Capcom |
| Street Fighter Alpha 2 | Super Nintendo Entertainment System | 1996 | Capcom |
| Street Fighter II | Super Nintendo Entertainment System, Game Boy, Wii | 1991 | Capcom |
| Street Fighter II Turbo | Super Nintendo Entertainment System | 1992 | Capcom |
| Street Fighter II: Champion Edition | Super Nintendo Entertainment System | 1992 | Capcom |
| Street Football 2 | Wii | 2009 | Dehon Games |
| Street Hockey '95 | Super Nintendo Entertainment System | 1994 | GTE Interactive Media |
| Street Hoops | Nintendo GameCube | 2002 | Black Ops Entertainment |
| Street Racer | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Street Racing Syndicate | Nintendo GameCube | 2004 | Eutechnyx |
| StreetPass Mii Plaza | Nintendo 3DS | 2011 | Nintendo Software Planning & Development |
| Stretchmo | Nintendo 3DS | 2015 | Intelligent Systems |
| Strider | Wii | 1989 | Capcom |
| Strider | Nintendo Entertainment System | 1989 | Capcom |
| Strike Force Bowling | Nintendo GameCube | 2004 | — |
| Strike Gunner S.T.G | Super Nintendo Entertainment System | 1992 | Athena |
| Striker | Super Nintendo Entertainment System | 1992 | Rage Games |
| Strong Bad's Cool Game for Attractive People: Season 1 | Wii | 2008 | Telltale Games |
| Strong Badia the Free | Wii | 2008 | Telltale Games |
| Stubbs the Zombie in Rebel Without a Pulse | Wii | 2005 | Wideload Games |
| Stunt Flyer: Hero of the Skies | Wii | 2010 | Nice Ideas |
| Stunt Kids | Nintendo Entertainment System | — | Codemasters |
| Stunt Race FX | Super Nintendo Entertainment System | 1994 | Nintendo Entertainment Analysis & Development |