| SimCity | Super Nintendo Entertainment System, Wii | 1989 | Nintendo Entertainment Analysis & Development, Maxis |
| SimCity 2000 | Super Nintendo Entertainment System | 1993 | Maxis, Full Fat |
| SimCity Creator | Wii | 2008 | Hudson Soft |
| SimEarth | Super Nintendo Entertainment System, Wii | 1990 | Maxis |
| Simple Series Vol. 4: The Misshitsu kara no Dasshutsu | Wii | 2009 | INTENSE |
| SimTown | Super Nintendo Entertainment System | 1995 | Maxis |
| Simulation Pro Yakyū | Super Nintendo Entertainment System | 1995 | Hect |
| Sin & Punishment: Star Successor | Wii | 2009 | Treasure |
| Sink or Swim | Super Nintendo Entertainment System | 1993 | Eutechnyx |
| Sir Ababol | Nintendo Entertainment System | 2012 | — |
| Skate It | Wii | 2008 | EA Montreal |
| Skate or Die 2: The Search for Double Trouble | Nintendo Entertainment System | 1990 | Electronic Arts |
| Skate or Die! | Nintendo Entertainment System | 1987 | Electronic Arts |
| Skate or Die: Bad 'N Rad | Game Boy | — | Konami |
| Skate or Die: Tour de Thrash | Game Boy | 1991 | Electronic Arts |
| Ski or Die | Nintendo Entertainment System | 1990 | Electronic Arts |
| Ski-Doo: Snowmobile Challenge | Wii | 2009 | Coldwood Interactive |
| Skies of Arcadia | Nintendo GameCube | 2000 | Sega Wow |
| Skull & Crossbones | Nintendo Entertainment System | 1987 | Atari Games |
| Sky Destroyer | Nintendo Entertainment System | 1985 | Magical Company |
| Sky Kid | Nintendo Entertainment System | 1985 | Namco |
| Sky Mission | Super Nintendo Entertainment System | 1992 | — |
| Skyblazer | Super Nintendo Entertainment System | 1994 | Ukiyotei |
| Skylanders: Giants | Nintendo 3DS, Wii | 2012 | Toys for Bob |
| Skylanders: Spyro's Adventure | Nintendo 3DS, Wii | 2011 | Toys for Bob |
| Skylanders: Swap Force | Nintendo 3DS, Wii | 2013 | Blizzard Albany |
| Skylanders: Trap Team | Nintendo 3DS | 2014 | Toys for Bob |
| Sküljagger: Revolt of the Westicans | Super Nintendo Entertainment System | 1992 | ASC Games |
| Slalom | Nintendo Entertainment System | 1987 | Rare Ltd. |
| Slam Dunk | Super Nintendo Entertainment System, Game Boy | 1994 | Tose Co. |
| Slam Dunk 2: IH Yosen Kanzenban!! | Super Nintendo Entertainment System, Game Boy | 1995 | — |
| Slayers | Super Nintendo Entertainment System | 1994 | — |
| Sled Shred featuring the Jamaican Bobsled Team | Wii | 2010 | — |
| Slice It! | Nintendo 3DS | — | Com2uS |
| Slime Mori Mori Dragon Quest 3 | Nintendo 3DS | 2011 | Square Enix |
| Small Soldiers | Game Boy | 1998 | — |
| Smart Ball | Super Nintendo Entertainment System | 1991 | Game Freak |
| Smarty Pants | Wii | 2007 | Planet Moon Studios |
| Smash Tennis | Super Nintendo Entertainment System | 1993 | Namco |
| Smash TV | Nintendo Entertainment System, Super Nintendo Entertainment System | 1990 | WMS Industries |
| Smashing Drive | Nintendo GameCube | 2002 | Gaelco |
| Smuggler's Run | Nintendo GameCube | 2000 | Rebellion Developments, Rockstar San Diego |
| Smuggler's Run: Warzones | Nintendo GameCube | 2002 | Rockstar San Diego |
| Snake Rattle 'n' Roll | Nintendo Entertainment System | 1990 | Rare Ltd. |
| Snake's Revenge | Nintendo Entertainment System | 1990 | Konami |
| Sneaky Snakes | Game Boy | — | Rare Ltd. |
| Sniper Elite | Wii | 2005 | Rebellion Developments |
| SNK Arcade Classics Vol. 1 | Wii | 2008 | Terminal Reality |
| Snoopy Concert | Super Nintendo Entertainment System | 1995 | Pax Softnica |
| Snoopy's Magic Show | Game Boy | 1990 | Kemco |
| Snoopy's Silly Sports Spectacular | Nintendo Entertainment System | 1988 | Kemco |
| Snow Bros.: Nick and Tom | Nintendo Entertainment System, Game Boy | 1990 | Toaplan |
| Snow White: Happily Ever After | Super Nintendo Entertainment System | 1994 | ASC Games |
| Snowboard Riot | Wii | 2009 | Hudson Soft |
| Snowpack Park | Wii | 2010 | skip Ltd. |
| So Blonde | Wii | 2008 | Wizarbox |
| So Blonde: Back to the Island | Wii | 2010 | Wizarbox |
| Soccer | Nintendo Entertainment System | 1985 | Intelligent Systems |
| Soccer | Game Boy | 1991 | Tose Co. |
| Soccer Kid | Super Nintendo Entertainment System | 1993 | Krisalis Software |