| Shin Megami Tensei II | Super Nintendo Entertainment System | 1994 | Atlus |
| Shin Megami Tensei IV | Nintendo 3DS | 2013 | Atlus |
| Shin Megami Tensei IV: Apocalypse | Nintendo 3DS | 2016 | Atlus |
| Shin Megami Tensei: Devil Survivor 2 Record Breaker | Nintendo 3DS | 2015 | — |
| Shin Megami Tensei: Devil Survivor Overclocked | Nintendo 3DS | 2011 | — |
| Shin Megami Tensei: Strange Journey Redux | Nintendo 3DS | 2017 | Atlus |
| Shin Momotaro Densetsu | Super Nintendo Entertainment System | 1993 | — |
| Shin Nekketsu Kōha: Kunio-tachi no Banka | Super Nintendo Entertainment System | 1994 | Givro |
| Shin Onigashima | Super Nintendo Entertainment System | 1987 | Nintendo Entertainment Analysis & Development, Pax Softnica |
| Shin SD Gundam Gaiden | Game Boy | 1994 | — |
| Shin SD Gundam Gaiden: Knight Gundam Monogatari | Game Boy | 1994 | Bandai |
| Shin SD Sengokuden: Daishōgun Retsuden | Super Nintendo Entertainment System | — | Bandai |
| Shin Seikoku: La Wares | Super Nintendo Entertainment System | 1995 | — |
| Shingen the Ruler | Nintendo Entertainment System | 1989 | Another |
| Shinobi | Nintendo Entertainment System | 1987 | Sega |
| Shinobi | Nintendo 3DS | 2011 | Griptonite Games |
| Shinseiki GPX Cyber Formula: Road to the Evolution | Nintendo GameCube | 2004 | Sunrise Interactive |
| Shinseiki Odysselya | Super Nintendo Entertainment System | 1993 | — |
| Shinseiki Odysselya II | Super Nintendo Entertainment System | 1995 | — |
| Shippū! Iron Leaguer | Game Boy | 1994 | — |
| Shiren the Wanderer | Wii | 2008 | Chunsoft |
| Shiroi Ringu he | Super Nintendo Entertainment System | 1995 | — |
| Shockwave | Nintendo Entertainment System | 1990 | American Game Cartridges |
| Shodai Nekketsu Kouha Kunio-Kun | Super Nintendo Entertainment System | 1992 | — |
| Shoot the Ball | Nintendo 3DS | 2016 | RCMADIAX |
| Shooting Range | Nintendo Entertainment System | 1989 | Tose Co. |
| Short Order / Eggsplode! | Nintendo Entertainment System | 1989 | Tose Co. |
| Shovel Knight | PlayStation Vita, Nintendo 3DS | 2014 | Yacht Club Games |
| Shovel Knight: Specter of Torment | Nintendo 3DS | 2017 | Yacht Club Games |
| Shovel Knight: Treasure Trove | PlayStation Vita, Nintendo 3DS | 2014 | Yacht Club Games |
| Showtime Championship Boxing | Wii | 2007 | Nikitova Games |
| Shrek | Nintendo GameCube | 2001 | DICE |
| Shrek 2 | Nintendo GameCube | 2004 | KnowWonder |
| Shrek Extra Large | Nintendo GameCube | 2002 | DICE |
| Shrek Forever After | Wii | 2010 | XPEC Entertainment |
| Shrek Smash n' Crash Racing | Nintendo GameCube | 2006 | Torus Games |
| Shrek Super Party | Nintendo GameCube | 2002 | Mass Media Inc. |
| Shrek SuperSlam | Nintendo GameCube | 2005 | 7 Studios, Shaba Games |
| Shrek the Third | Wii | 2007 | Shaba Games |
| Shrek's Carnival Craze | Wii | 2008 | Nordcurrent |
| Shuffle Fight | Nintendo Entertainment System | 1992 | Pandora Box |
| Shufflepuck Café | Nintendo Entertainment System | 1989 | Broderbund |
| Shutokō Battle '94: Drift King Tsuchiya Keiichi & Bandō Masaaki | Super Nintendo Entertainment System | 1994 | Genki |
| Shuyaku Sentai Irem Fighter | Game Boy | 1993 | Irem |
| Shōgi Saikyō | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Shōnin yo Taishi wo Idake!! | Super Nintendo Entertainment System | 1995 | Fortyfive |
| Sid Meier's Pirates! | Wii | 2004 | Firaxis Games |
| Sid Meier's Pirates! | Nintendo Entertainment System, Apple II series | 1987 | MicroProse |
| Side Pocket | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1986 | Data East |
| Silent Assault | Nintendo Entertainment System | 1990 | Thin Chen Enterprise |
| Silent Hill: Shattered Memories | Wii | 2009 | Climax Studios |
| Silent Service | Nintendo Entertainment System | 1985 | MicroProse |
| Silk Worm | Nintendo Entertainment System | 1988 | Tecmo |
| Silva Saga II: The Legend of Light and Darkness | Super Nintendo Entertainment System | 1993 | SETA Corporation |
| Silver Star Chess | Wii | 2008 | Agetec |
| Silver Star Reversi | Wii | 2008 | Agetec |
| Silver Surfer | Nintendo Entertainment System | 1990 | Software Creations |
| Sim City | Nintendo Entertainment System, Super Nintendo Entertainment System, Wii | 1991 | Electronic Arts |
| SimAnimals | Wii | 2009 | Electronic Arts |
| SimAnt | Super Nintendo Entertainment System | 1991 | Maxis |