| Logos Panic | Super Nintendo Entertainment System | 1995 | — |
| London Taxi: Rush Hour | Wii | 2008 | Data Design Interactive |
| Looney Tunes | Game Boy | 1992 | Sunsoft |
| Looney Tunes B-Ball | Super Nintendo Entertainment System | 1995 | Sculptured Software |
| Looney Tunes: Acme Arsenal | Wii | 2007 | Redtribe |
| Looney Tunes: Back in Action | Nintendo GameCube | 2003 | Warner Bros. Games |
| Loopz | Nintendo Entertainment System | 1990 | Milestone S.r.l., Audiogenic |
| Lord Monarch | Super Nintendo Entertainment System | 1992 | Nihon Falcom |
| Lord of Magna: Maiden Heaven | Nintendo 3DS | 2014 | Marvelous |
| Lost Heroes 2 | Nintendo 3DS | 2015 | — |
| Lost in Blue: Shipwrecked | Wii | 2008 | Hudson Soft |
| Lost in Shadow | Wii | 2010 | Hudson Soft |
| Lost Kingdoms | Nintendo GameCube | 2002 | FromSoftware |
| Lost Kingdoms II | Nintendo GameCube | 2003 | FromSoftware |
| Lost Word of Jenny | Nintendo Entertainment System | 1987 | Tose Co. |
| LostWinds | Wii | 2008 | Frontier Developments |
| LostWinds 2: Winter of the Melodias | Wii | 2009 | Frontier Developments |
| Lot Lot | Nintendo Entertainment System | 1985 | Irem |
| Lotus Challenge | Nintendo GameCube | 2001 | Kuju Ltd. |
| Love Quest | Super Nintendo Entertainment System | 1995 | — |
| Low G Man: The Low Gravity Man | Nintendo Entertainment System | 1990 | KID |
| Lucha Libre AAA: Héroes del Ring | Wii | 2010 | Immersion Games |
| Lucky Luke | Game Boy | 1996 | VD-dev |
| Lucky Luke | Super Nintendo Entertainment System | 1997 | Infogrames |
| Lufia & the Fortress of Doom | Super Nintendo Entertainment System | 1993 | Neverland |
| Lufia II: Rise of the Sinistrals | Super Nintendo Entertainment System | 1995 | Neverland |
| Luigi's Mansion | Nintendo GameCube | 2001 | Grezzo, Nintendo Entertainment Analysis & Development |
| Luigi's Mansion | Nintendo 3DS | 2018 | Grezzo |
| Luigi's Mansion: Dark Moon | Nintendo 3DS | 2013 | Next Level Games |
| Lunar Lander | Game Boy | 1990 | Pack-In-Video |
| Lunar Pool | Nintendo Entertainment System | 1985 | Compile |
| Lupin III: Densetsu no Hihō o Oe! | Super Nintendo Entertainment System | 1994 | — |
| Lupin III: Pandora no Isan | Nintendo Entertainment System | 1987 | Tose Co. |
| Lupin the 3rd: Lost Treasure Under the Sea | Nintendo GameCube | 2003 | Asmik Ace Entertainment |
| Luv Me Buddies Wonderland | Nintendo 3DS | 2014 | — |
| Luxor 2 | Wii | 2006 | MumboJumbo |
| Luxor 3 | Wii | 2007 | MumboJumbo |
| M&M's Adventure | Wii | 2008 | Nikitova Games |
| M&M's Beach Party | Wii | 2009 | Digital Embryo |
| M&M's Kart Racing | Wii | 2007 | FrontLine Studios |
| M.C. Kids | Nintendo Entertainment System, Game Boy | 1992 | Visual Concepts, Virgin Interactive, Arc Developments |
| M.U.L.E. | Nintendo Entertainment System | 1983 | Ozark Softscape |
| MaBoShi: The Three Shape Arcade | Wii | 2008 | Mindware Corp. |
| Mach Rider | Nintendo Entertainment System | 1985 | Nintendo Research & Development 2 |
| Machine Knight | Nintendo 3DS | 2012 | — |
| Mad Dog II: The Lost Gold | Wii | 1992 | American Laser Games |
| Mad Dog McCree | Wii | 1993 | American Laser Games |
| Mad Max | Nintendo Entertainment System | 1990 | Mindscape |
| Mad Tracks | Wii | 2007 | Load Inc. |
| Madagascar | Nintendo GameCube | 2005 | Toys for Bob |
| Madagascar 3: The Video Game | Nintendo 3DS, Wii | 2012 | Monkey Bar Games |
| Madagascar Kartz | Wii | 2009 | Sidhe |
| Madagascar: Escape 2 Africa | Wii | 2008 | Toys for Bob |
| Madden NFL '94 | Super Nintendo Entertainment System | 1993 | EA Orlando |
| Madden NFL '95 | Super Nintendo Entertainment System, Game Boy | 1994 | Electronic Arts |
| Madden NFL '96 | Super Nintendo Entertainment System | 1995 | EA Orlando |
| Madden NFL 06 | Nintendo GameCube | 2005 | EA Orlando |
| Madden NFL 07 | Nintendo GameCube, Wii | 2006 | EA Orlando |
| Madden NFL 08 | Nintendo GameCube, Wii | 2007 | EA Orlando |
| Madden NFL 09 | Wii | 2008 | EA Orlando |