| Alvin and the Chipmunks: Chipwrecked | Wii | 2011 | Behaviour Interactive |
| Alvin and the Chipmunks: The Squeakquel | Wii | 2009 | ImaginEngine |
| Amagon | Nintendo Entertainment System | 1988 | Aicom |
| Amazing Island | Nintendo GameCube | 2004 | Sega AM3 |
| Amazing Penguin | Game Boy | 1990 | Winning Entertainment Group |
| Amazing Tater | Game Boy | 1991 | Atlus |
| Ambition of the Slimes | PlayStation Vita, Nintendo 3DS | 2014 | — |
| America Daitōryō Senkyo | Nintendo Entertainment System | 1988 | Hect |
| America Ōdan Ultra Quiz | Super Nintendo Entertainment System | 1992 | — |
| America's Next Top Model | Wii | 2010 | Neopica |
| American Battle Dome | Super Nintendo Entertainment System | 1995 | — |
| American Chopper 2: Full Throttle | Nintendo GameCube | 2005 | Creat Studios |
| American Dream | Nintendo Entertainment System | 1989 | C-Dream |
| American Gladiators | Nintendo Entertainment System, Super Nintendo Entertainment System | 1991 | Incredible Technologies |
| American Mensa Academy | Wii | 2012 | Silverball Studios |
| AMF Bowling Pinbusters! | Wii | 2007 | Atomic Planet Entertainment |
| AMF Bowling World Lanes | Wii | 2008 | Vir2L Studios |
| Amida | Game Boy | 1990 | — |
| An American Tail: Fievel Goes West | Super Nintendo Entertainment System | 1994 | Hudson Soft |
| Ancient Magic: Bazoe! Mahou Sekai | Super Nintendo Entertainment System | 1993 | — |
| And Yet It Moves | Wii | 2009 | Broken Rules |
| And-Kensaku | Wii | 2010 | Shift |
| Andre Agassi Tennis | Super Nintendo Entertainment System | 1994 | — |
| Angelique | Super Nintendo Entertainment System | 1994 | Koei Tecmo Holdings |
| Angler's Club: Ultimate Bass Fishing 3D | Nintendo 3DS | 2011 | — |
| Angry Birds | Nintendo 3DS, Wii | 2009 | Rovio Entertainment |
| Angry Birds Star Wars | PlayStation Vita, Nintendo 3DS, Wii | 2012 | Rovio Entertainment |
| Angry Birds Trilogy | PlayStation Vita, Wii | 2012 | Rovio Entertainment |
| Angry Bunnies: Colossal Carrot Crusade | Nintendo 3DS | 2014 | Cypronia |
| Angry Video Game Nerd 8-bit | Nintendo Entertainment System | 2025 | Mega Cat Studios |
| Animal Crossing | Nintendo GameCube | 2001 | Nintendo Entertainment Analysis & Development |
| Animal Crossing e+ | Nintendo GameCube | 2003 | — |
| Animal Crossing: City Folk | Wii | 2008 | Nintendo Entertainment Analysis & Development |
| Animal Crossing: Happy Home Designer | Nintendo 3DS | 2015 | Nintendo Entertainment Analysis & Development |
| Animal Crossing: New Leaf | Nintendo 3DS | 2012 | Monolith Soft Inc., Nintendo Entertainment Analysis & Development |
| Animal Kingdom: Wildlife Expedition | Wii | 2008 | Success |
| Animal Planet: Vet Life | Wii | 2009 | Big Blue Bubble, SilverBirch Studios |
| Animaniacs | Super Nintendo Entertainment System, Game Boy | 1994 | Konami |
| Animaniacs: The Great Edgar Hunt | Nintendo GameCube | 2005 | Warthog Games |
| Anime Slot Revolution: Pachi-Slot Kidō Senshi Gundam II - Ai Senshi Hen | Wii | 2007 | Yamasa |
| Anno: Create A New World | Wii | 2009 | Keen Games |
| ANNO: Mutationem | Nintendo 3DS | 2022 | — |
| Another Bible | Game Boy | 1995 | — |
| Another Code: R – A Journey into Lost Memories | Wii | 2009 | Cing |
| Another World | Super Nintendo Entertainment System | 1991 | Delphine Software International, Éric Chahi |
| Ant Nation | Wii | 2009 | Konami |
| Antarctic Adventure | Nintendo Entertainment System | 1983 | Konami |
| Anticipation | Nintendo Entertainment System | 1988 | Rare Ltd. |
| Anubis II | Wii | 2005 | Data Design Interactive |
| Aoki Densetsu Shoot! | Super Nintendo Entertainment System | 1994 | Affect |
| Apollo Justice: Ace Attorney | Nintendo 3DS | 2007 | Capcom |
| Appleseed | Super Nintendo Entertainment System | 1994 | — |
| Aqua Panic! | Wii | 2008 | Eko Software |
| Aquaman: Battle for Atlantis | Nintendo GameCube | 2003 | Lucky Chicken Games |
| Aquatic Tales | Wii | — | GameInvest, S.A., Activision |
| AR Games | Nintendo 3DS | 2011 | Nintendo |
| Arabian | Nintendo Entertainment System | 1983 | Sunsoft |
| Arabian Nights: Sabaku no Seirei-ō | Super Nintendo Entertainment System | 1996 | — |
| Arc Rise Fantasia | Wii | 2009 | Imageepoch |
| Arcade Classic | Game Boy | 1995 | WMS Industries, Backbone Entertainment |