| Agent Hugo: Hula Holiday | Wii | 2008 | Attractive Games Ltd. |
| Agent Hugo: Lemoon Twist | Wii | 2007 | Coyote Console |
| Aggressive Inline | Nintendo GameCube | 2002 | Underground Development |
| Aguri Suzuki F-1 Super Driving | Super Nintendo Entertainment System | 1992 | Genki |
| Ai Sensei no Oshiete: Watashi no Hoshi | Nintendo Entertainment System | 1993 | Irem |
| Aighina no Yogen: From the Legend of Balubalouk | Nintendo Entertainment System | 1986 | Tokai Communications |
| Aikatsu Stars! First Appeal | Nintendo 3DS | 2016 | h.a.n.d. |
| Aikatsu Stars! My Special Appeal | Nintendo 3DS | 2016 | h.a.n.d. |
| Aikatsu! 365 Idol Days | Nintendo 3DS | 2014 | — |
| Aikatsu! Both of my princesses | Nintendo 3DS | 2013 | — |
| Aikatsu! Cinderella Lesson | Nintendo 3DS | 2012 | — |
| Aikatsu! My No.1 Stage! | Nintendo 3DS | 2015 | — |
| Aim for the Ace! | Super Nintendo Entertainment System | 1993 | Telenet Japan |
| Air Cavalry | Super Nintendo Entertainment System | 1995 | Synergistic Software |
| Air Fortress | Nintendo Entertainment System | 1987 | HAL Laboratory |
| AiRace Speed | PlayStation Vita, Nintendo 3DS | 2013 | — |
| Airwolf | Nintendo Entertainment System | 1987 | Sanritsu Denki |
| Airwolf | Nintendo Entertainment System | 1988 | Krome Studios Melbourne |
| Akagawa Jirō no Yūrei Ressha | Nintendo Entertainment System | 1991 | Mighty Craft Co. |
| Akira | Nintendo Entertainment System | 1988 | Taito, Tose Co. |
| Akira | Super Nintendo Entertainment System, Game Boy | — | Black Pearl Software |
| Akuma-kun | Nintendo Entertainment System | 1989 | Tose Co. |
| Al Unser Jr.'s Road to the Top | Super Nintendo Entertainment System | 1994 | Radical Entertainment |
| Al Unser Jr.'s Turbo Racing | Nintendo Entertainment System | 1989 | Data East |
| Aladdin Magic Racer | Wii | 2010 | Mighty Rocket Studio |
| Alan Hansen's Sports Challenge | Wii | 2007 | The Code Monkeys, Oxygen Studios |
| Albert Odyssey | Super Nintendo Entertainment System | 1993 | Sunsoft |
| Albert Odyssey 2: Jashin no Taidou | Super Nintendo Entertainment System | — | Sunsoft |
| Albert Odyssey II: Jashin no Taidou | Super Nintendo Entertainment System | 1996 | — |
| Alcahest | Super Nintendo Entertainment System | 1993 | HAL Laboratory |
| Alchemic Dungeons | Nintendo 3DS | 2015 | — |
| Alentejo: The Tinto and The Ugly | Game Boy | — | Loading Studios |
| Alentejo: Tinto's Law | Game Boy | 2024 | — |
| Alfred Chicken | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1993 | Twilight |
| Alice in Wonderland | Wii | 2010 | Étranges Libellules |
| Alice no Paint Adventure | Super Nintendo Entertainment System | 1995 | — |
| Alien 3 | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1992 | Acclaim Studios London, Bits Studios |
| Alien Crush Returns | Wii | 2008 | Tamsoft |
| Alien Hominid | Nintendo GameCube | 2004 | The Behemoth |
| Alien Syndrome | Nintendo Entertainment System | 1987 | Sega |
| Alien Syndrome | Wii | 2007 | Totally Games |
| Alien vs Predator: The Last of His Clan | Game Boy | 1993 | — |
| Alien vs. Predator | Super Nintendo Entertainment System | 1993 | — |
| Aliens in the Attic | Wii | 2009 | Revistronic |
| All Kamen Rider: Rider Revolution | Nintendo 3DS | 2016 | — |
| All Round Hunter | Wii | 2010 | SIMS Co., Ltd. |
| All Star Cheer Squad 2 | Wii | 2009 | Gorilla Systems |
| All Star Karate | Wii | 2010 | Blitz Games |
| All-Pro Basketball | Nintendo Entertainment System | 1989 | Aicom |
| All-Star Baseball 2002 | Nintendo GameCube | 2001 | — |
| All-Star Baseball 2003 | Nintendo GameCube | 2002 | Acclaim Studios Austin, Software Creations |
| All-Star Cheer Squad | Wii | 2008 | Gorilla Systems |
| Alleyway | Game Boy | 1989 | Nintendo Research & Development 1 |
| Almost Hero | Nintendo Entertainment System | 2016 | Mega Cat Studios |
| Alone in the Dark | Wii | 2008 | Eden Games |
| Alpha Mission | Nintendo Entertainment System | 1986 | SNK |
| Alphadia | Nintendo 3DS | 2011 | Exe-Create |
| Altered Beast | Nintendo Entertainment System | 1988 | Sega |
| Altered Space | Game Boy | 1991 | Software Creations |
| Alvin and the Chipmunks | Wii | 2007 | Sensory Sweep Studios |