| WWII Aces | Wii | 2008 | Arcade Moon |
| X | Game Boy | 1992 | Nintendo Entertainment Analysis & Development, Argonaut Games |
| X-Kaliber 2097 | Super Nintendo Entertainment System | 1994 | — |
| X-Men Legends | Nintendo GameCube | 2004 | Raven Software, Barking Lizards Technologies |
| X-Men Legends II: Rise of Apocalypse | Nintendo GameCube | 2005 | Raven Software |
| X-Men Origins: Wolverine | Wii | 2009 | Raven Software |
| X-Men: Destiny | Wii | 2011 | Silicon Knights |
| X-Men: Mutant Apocalypse | Super Nintendo Entertainment System | 1994 | Capcom |
| X-Men: Next Dimension | Nintendo GameCube | 2002 | Midway Studios – Los Angeles |
| X-Men: The Official Game | Nintendo GameCube | 2006 | Underground Development |
| X-Zone | Super Nintendo Entertainment System | 1992 | Kemco |
| X2: Wolverine's Revenge | Nintendo GameCube | 2003 | — |
| Xak: The Art of Visual Stage | Super Nintendo Entertainment System | 1992 | Microcabin |
| Xandra no Daibōken: Valkyrie to no Deai | Super Nintendo Entertainment System | 1992 | — |
| Xardion | Super Nintendo Entertainment System | 1992 | Jorudan |
| Xeno Crisis | Nintendo GameCube | 2019 | Bitmap Bureau |
| Xenoblade Chronicles | Wii | 2010 | Monolith Soft Inc. |
| Xenoblade Chronicles 3D | Nintendo 3DS | 2015 | — |
| Xenophobe | Nintendo Entertainment System | 1987 | Midway Games, Sunsoft |
| Xevious | Nintendo Entertainment System | 1982 | Namco |
| Xexyz | Nintendo Entertainment System | 1988 | Hudson Soft |
| XGRA: Extreme G Racing Association | Nintendo GameCube | 2003 | Acclaim Studios London |
| XIII | Nintendo GameCube | 2003 | Ubisoft Paris |
| Yadamon - Wonderland Dreams | Super Nintendo Entertainment System | 1993 | — |
| Yae | Super Nintendo Entertainment System | 1996 | Konami |
| Yakuman | Game Boy | 1989 | Intelligent Systems |
| Yakuman Houou | Nintendo 3DS | 2015 | Lancarse, Nintendo |
| Yakōchū | Super Nintendo Entertainment System | 1995 | Athena |
| Yamaha Supercross | Wii | 2008 | Beyond Reality Games |
| Yeti3DS | Nintendo 3DS | — | smealum |
| Yie Ar Kung-Fu | Nintendo Entertainment System | 1985 | Konami |
| Yo! Noid | Nintendo Entertainment System | 1990 | Now Production |
| Yo-kai Watch | Nintendo 3DS | 2013 | Level-5 |
| Yo-kai Watch 2 | Nintendo 3DS | 2014 | Level-5 |
| Yo-kai Watch 2: Bony Spirits | Nintendo 3DS | 2014 | Level-5 |
| Yo-kai Watch 2: Fleshy Souls | Nintendo 3DS | 2014 | Level-5 |
| Yo-kai Watch 2: Psychic Specters | Nintendo 3DS | 2014 | Level-5 |
| Yo-kai Watch 3 | Nintendo 3DS | 2016 | Level-5 |
| Yo-kai Watch Blasters | Nintendo 3DS | 2015 | Level-5 |
| Yo-kai Watch Blasters 2 | Nintendo 3DS | 2017 | Level-5 |
| Yoga Wii | Wii | 2009 | Trine Games |
| Yogi Bear's Gold Rush | Game Boy | 1994 | — |
| Yogi Bear: The Video Game | Wii | 2010 | Vicious Cycle Software |
| Yokai Club | Nintendo Entertainment System | 1987 | Tose Co. |
| Yokai Dochuki | Nintendo Entertainment System | 1987 | Namco |
| Yokoyama Mitsuteru Sangokushi | Super Nintendo Entertainment System | 1992 | — |
| Yokozuna Monogatari | Super Nintendo Entertainment System | 1994 | — |
| Yoshi | Nintendo Entertainment System, Game Boy | 1991 | Game Freak |
| Yoshi no Cookie: Kuruppon Oven de Cookie | Super Nintendo Entertainment System | 1994 | — |
| Yoshi Racing | Super Nintendo Entertainment System | — | Argonaut Games |
| Yoshi's Cookie | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1992 | Bullet-Proof Software, Tose Co. |
| Yoshi's New Island | Nintendo 3DS | 2014 | Arzest |
| Yoshi's Safari | Super Nintendo Entertainment System | 1993 | Nintendo Research & Development 1 |
| Yoshi's Woolly World | Nintendo 3DS | 2015 | Good-Feel |
| You Don't Know Jack | Wii | 2011 | Jackbox Games |
| You, Me, and the Cubes | Wii | 2009 | D Wonderland Inc., fyto |
| Young Merlin | Super Nintendo Entertainment System | 1994 | Westwood Studios |
| Your Shape | Wii | 2009 | Ubisoft |
| Ys I | Nintendo Entertainment System | 1987 | Nihon Falcom |
| Ys I & II | Wii | 1989 | Nihon Falcom, Alfa System |