| Ys II | Nintendo Entertainment System | 1988 | Nihon Falcom |
| Ys III: Wanderers from Ys | Nintendo Entertainment System, Super Nintendo Entertainment System | 1989 | Nihon Falcom |
| Ys IV: Mask of the Sun | Super Nintendo Entertainment System | 1993 | Tonkin House |
| Ys V: Lost Kefin, Kingdom of Sand | Super Nintendo Entertainment System | 1995 | Nihon Falcom |
| Yu Yu Hakusho | Game Boy | 1993 | — |
| Yu Yu Hakusho | Super Nintendo Entertainment System | 1993 | — |
| Yu-Gi-Oh! 5D's Duel Transer | Wii | 2010 | Konami Digital Entertainment |
| Yu-Gi-Oh! 5D's Wheelie Breakers | Wii | 2009 | Konami |
| Yu-Gi-Oh! The Falsebound Kingdom | Nintendo GameCube | 2002 | Konami |
| Yu-Gi-Oh! Zexal: World Duel Carnival | Nintendo 3DS | 2014 | — |
| Yume Penguin Monogatari | Nintendo Entertainment System | 1991 | Konami |
| Yummy Yummy Cooking Jam | Wii | 2008 | Virtual Toys |
| Yuujin no Furi Furi Girls | Super Nintendo Entertainment System | 1994 | — |
| Yū Yū Hakusho Final | Super Nintendo Entertainment System | 1995 | Tose Co. |
| Yūyu no Quiz de Go! Go! | Super Nintendo Entertainment System | 1991 | — |
| Zack & Wiki: Quest for Barbaros' Treasure | Wii | 2007 | Capcom |
| Zakuro no Aji | Super Nintendo Entertainment System | 1995 | — |
| Zan II: Spirits | Super Nintendo Entertainment System | 1992 | Namco Tales Studio |
| Zanac | Nintendo Entertainment System | 1986 | Compile |
| Zangeki no Reginleiv | Wii | 2010 | Sandlot |
| Zapper: One Wicked Cricket | Nintendo GameCube | 2002 | Blitz Games |
| Zatch Bell! Mamodo Battles | Nintendo GameCube | 2005 | Eighting |
| Zatch Bell! Mamodo Fury | Nintendo GameCube | 2005 | — |
| Zelda II: The Adventure of Link | Nintendo Entertainment System | 1987 | Nintendo Entertainment Analysis & Development |
| Zen the Intergalactic Ninja | Game Boy | 1992 | — |
| Zen the Intergalactic Ninja | Nintendo Entertainment System | 1993 | — |
| Zen-Nippon GT Senshuken | Super Nintendo Entertainment System | 1995 | — |
| Zen-Nippon Pro Wrestling | Super Nintendo Entertainment System | 1993 | — |
| Zen: Intergalactic Ninja | Nintendo Entertainment System, Game Boy | 1993 | Konami |
| Zenkoku Kōkō Soccer | Super Nintendo Entertainment System | 1994 | — |
| Zenkoku Kōkō Soccer 2 | Super Nintendo Entertainment System | 1995 | — |
| Zenkoku Kōkō Soccer Senshuken '96 | Super Nintendo Entertainment System | 1996 | — |
| Zero Escape: Virtue's Last Reward | PlayStation Vita, Nintendo 3DS | 2012 | Chunsoft |
| Zero the Kamikaze Squirrel | Super Nintendo Entertainment System | 1994 | Acclaim Studios Austin |
| Zero Time Dilemma | PlayStation Vita, Nintendo 3DS | 2016 | Spike Chunsoft |
| Zero4 Champ: RR | Super Nintendo Entertainment System | 1994 | Media Rings |
| Zero4 Champ: RR-Z | Super Nintendo Entertainment System | 1995 | Media Rings |
| Zeus Quest Remastered | Nintendo 3DS | 2016 | — |
| Zico Soccer | Super Nintendo Entertainment System | 1994 | — |
| Zig Zag Cat: Dachō Club mo Oosawagi da | Super Nintendo Entertainment System | 1994 | — |
| Zoda's Revenge: StarTropics II | Nintendo Entertainment System | 1994 | Nintendo development teams |
| Zoids Densetsu | Game Boy, Nintendo 3DS | 1990 | — |
| Zoids: Mokushiroku | Nintendo Entertainment System | 1990 | Tomy |
| Zombie Nation | Nintendo Entertainment System | 1990 | Empty Clip Studios, KAZe |
| Zombie Panic in Wonderland | Wii | 2010 | Akaoni Studio |
| Zombies Ate My Neighbors | Super Nintendo Entertainment System | 1993 | Lucasfilm Games |
| Zoo Disc Golf | Wii | 2010 | Sonalysts (United States) |
| Zoo Hospital | Wii | 2008 | Torus Games |
| Zoo Keeper | Nintendo 3DS | 2002 | Success, KITERETSU, Robot Communications |
| Zoo Resort 3D | Nintendo 3DS | 2011 | AQ Interactive |
| ZooCube | Nintendo GameCube | 2002 | — |
| Zool | Super Nintendo Entertainment System | 1992 | Gremlin Interactive |
| Zoop | Super Nintendo Entertainment System | 1995 | — |
| Zumba Fitness | Wii | 2010 | Pipeworks Software |
| Zumba Fitness 2 | Wii | 2011 | Zoë Mode |
| Zumba Fitness Core | Wii | 2012 | Zoë Mode |
| Zumba Fitness: World Party | Wii | 2013 | Zoë Mode |
| Zumba Kids | Wii | 2013 | Zoë Mode |
| Zunō Senkan Galg | Nintendo Entertainment System | 1985 | Team Bioteckers |
| Ōgon no Kizuna | Wii | 2009 | CAVE |