| Universal Studios Theme Parks Adventure | Nintendo GameCube | 2001 | Kemco |
| Up | Wii | 2009 | Heavy Iron Studios |
| Urban Champion | Nintendo Entertainment System | 1984 | Nintendo Research & Development 1 |
| Urban Extreme: Street Rage | Wii | 2008 | Data Design Interactive |
| Urban Strike | Super Nintendo Entertainment System, Game Boy | 1994 | — |
| Urban Trial Freestyle | PlayStation Vita, Nintendo 3DS | 2013 | Tate Multimedia |
| Urbanix | Wii | 2011 | Nordcurrent |
| Ushio to Tora: Shin'en no Daiyō | Nintendo Entertainment System | 1993 | Pixel |
| Utopia: The Creation of a Nation | Super Nintendo Entertainment System | 1991 | — |
| Utsurun Desu.: Kawauso Hawaii e Iku!!! | Nintendo Entertainment System | 1992 | Tomy |
| V-Rally 3 | Nintendo GameCube | 2002 | Eden Games |
| V.I.P. Casino: Blackjack | Wii | 2008 | High Voltage Software |
| Vacation Adventures: Park Ranger | Nintendo 3DS | 2014 | Casual Arts |
| Valhalla Knights: Eldar Saga | Wii | 2009 | K2 |
| Valis: The Fantasm Soldier | Nintendo Entertainment System | 1987 | Telenet Japan |
| Valkyrie no Bōken: Toki no Kagi Densetsu | Nintendo Entertainment System | 1986 | Namco |
| Vectorman | Wii | 1995 | BlueSky Software |
| Vegas Connection: Casino Kara Ai wo Komete | Nintendo Entertainment System | 1989 | Graphic Research Co., Ltd. |
| Vegas Dream | Nintendo Entertainment System | 1988 | HAL Laboratory |
| Vegas Stakes | Super Nintendo Entertainment System | 1993 | HAL Laboratory |
| Venice Beach Volleyball | Nintendo Entertainment System | 1991 | — |
| Venom/Spider-Man: Separation Anxiety | Super Nintendo Entertainment System | 1995 | Software Creations |
| Venus Redemption | Wii | — | nDreams |
| Verne World | Super Nintendo Entertainment System | 1995 | — |
| Vertigo | Wii | 2008 | Super Icon |
| Vexed | Game Boy | 2023 | — |
| Vexx | Nintendo GameCube | 2003 | Acclaim Studios Austin |
| Vice: Project Doom | Nintendo Entertainment System | 1991 | Aicom |
| Victorious Boxers: Revolution | Wii | 2007 | Cavia |
| Victorious: Taking the Lead | Wii | 2012 | High Voltage Software |
| Victory Road | Nintendo Entertainment System | 1986 | SNK |
| Videomation | Nintendo Entertainment System | 1991 | FarSight Studios |
| Viewtiful Joe | Nintendo GameCube | 2003 | Clover Studio |
| Viewtiful Joe 2 | Nintendo GameCube | 2004 | Clover Studio |
| Viewtiful Joe: Red Hot Rumble | Nintendo GameCube | 2005 | Clover Studio |
| Vindicators | Nintendo Entertainment System | 1988 | Tengen |
| Virtua Quest | Nintendo GameCube | 2004 | Sega AM2 |
| Virtua Striker 3 | Nintendo GameCube | 2001 | — |
| Virtua Tennis 2009 | Wii | 2009 | Sumo Digital |
| Virtua Tennis 4 | PlayStation Vita, Wii | 2011 | Sega AM3 |
| Virtual Bart | Super Nintendo Entertainment System | 1994 | Sculptured Software |
| Virtual Soccer | Super Nintendo Entertainment System | 1994 | Acclaim Studios London |
| Volguard II | Nintendo Entertainment System | 1985 | dB-SOFT |
| Volleyball | Nintendo Entertainment System | 1986 | Nintendo Research & Development 1 |
| Vortex | Super Nintendo Entertainment System | 1994 | Argonaut Games |
| VVVVVV | PlayStation Vita, Nintendo 3DS | 2010 | Terry Cavanagh |
| Wacky Races | Nintendo Entertainment System | 1991 | Fumariaceae, Atlus |
| Wacky Races: Crash and Dash | Wii | 2008 | Eidos Interactive |
| Wacky World of Sports | Wii | 2009 | Tabot |
| Wagamama Fashion: Girls Mode - Yokubari Sengen! Tokimeki Up! | Nintendo 3DS | 2014 | — |
| Wagan Land | Nintendo Entertainment System | 1989 | Now Production |
| Wagan Paradise | Super Nintendo Entertainment System | 1994 | — |
| Wai Wai World 2: SOS!! Parsley Jō | Nintendo Entertainment System | 1991 | Konami |
| Waka Taka Ōzumō: Brothers Dream Match | Super Nintendo Entertainment System | 1993 | — |
| Waku Waku 7 | Super Nintendo Entertainment System, Nintendo 3DS | 1996 | Sunsoft |
| Waku Waku Ski Wonder Spur | Super Nintendo Entertainment System | 1995 | — |
| Wall Street Kid | Nintendo Entertainment System | 1989 | SOFEL |
| WALL-E | Wii | 2008 | Heavy Iron Studios |
| Wallace & Gromit in Project Zoo | Nintendo GameCube | 2003 | Frontier Developments |
| Wally Bear and the NO! Gang | Nintendo Entertainment System | 1992 | American Game Cartridges |