| The Sims 3 (Wii) | Wii | 2010 | Maxis |
| The Sims 3: Pets | Nintendo 3DS | 2011 | Maxis |
| The Sims Bustin' Out | Nintendo GameCube | 2003 | Maxis, Griptonite Games |
| The Sky Crawlers: Innocent Aces | Wii | 2008 | Access Games |
| The Smurfs 2 | Wii | 2013 | WayForward Technologies |
| The Smurfs Dance Party | Wii | 2011 | Land Ho! |
| The Smurfs Travel the World | Super Nintendo Entertainment System | 1994 | Infogrames |
| The Smurfs' Nightmare | Game Boy | 1997 | VD-dev |
| The Spiderwick Chronicles | Wii | 2008 | Stormfront Studios |
| The SpongeBob SquarePants Movie | Nintendo GameCube | 2004 | Heavy Iron Studios |
| The Starship Damrey | Nintendo 3DS | 2013 | Level-5 |
| The Sum of All Fears | Nintendo GameCube | 2002 | Red Storm Entertainment |
| The Super Dimension Fortress Macross | Nintendo Entertainment System | 1985 | Namco |
| The Super Spy | Wii | 1990 | SNK, SNK |
| The Sword of Hope | Game Boy | 1989 | Kemco |
| The Sword of Hope II | Game Boy | 1992 | Kemco |
| The Tale of Despereaux | Wii | 2008 | Brash Entertainment |
| The Terminator | Nintendo Entertainment System | 1992 | Radical Entertainment |
| The Thieves and the 1000 Pokémon | Nintendo 3DS | 2014 | Marvelous |
| The Three Musketeers: One for all! | Wii | 2009 | Legendo Entertainment AB |
| The Three Stooges | Nintendo Entertainment System | 1987 | Beam Software |
| The Tick | Super Nintendo Entertainment System | 1994 | Software Creations |
| The Tower of Druaga | Nintendo Entertainment System | 1984 | Namco |
| The Transformers: Mystery of Convoy | Nintendo Entertainment System | 1986 | ISCO |
| The Triathron | Nintendo Entertainment System | 1988 | K. Amusement Leasing Co. |
| The Twisted Tales of Spike McFang | Super Nintendo Entertainment System | 1993 | Blue Planet Software |
| The Ultimate Stuntman | Nintendo Entertainment System | — | Codemasters |
| The Uncanny X-Men | Nintendo Entertainment System | 1989 | LJN |
| The Untouchables | Nintendo Entertainment System | 1989 | Special FX Software |
| The Untouchables | Super Nintendo Entertainment System | 1994 | — |
| The Urbz: Sims in the City | Nintendo GameCube | 2004 | Maxis |
| The Uwaki Kareshi | Nintendo 3DS | 2012 | — |
| The Wing of Madoola | Nintendo Entertainment System | 1986 | Sunsoft |
| The Wizard of Oz | Super Nintendo Entertainment System | 1993 | Electronic Arts |
| The World of Golden Eggs | Wii | 2008 | Artoon |
| The Young Indiana Jones Chronicles | Nintendo Entertainment System | 1992 | Gray Matter Inc. |
| Theatrhythm Dragon Quest | Nintendo 3DS | 2015 | indieszero |
| Theatrhythm Final Fantasy | Nintendo 3DS | 2012 | indieszero |
| Theatrhythm Final Fantasy: Curtain Call | Nintendo 3DS | 2014 | indieszero |
| Theme Park | Super Nintendo Entertainment System | 1995 | Bullfrog Productions |
| Thexder | Nintendo Entertainment System | 1985 | Game Arts |
| Thomas the Tank Engine & Friends | Super Nintendo Entertainment System | 1993 | Software Creations |
| Thor: God of Thunder | Wii | 2011 | Liquid Entertainment |
| Thoroughbred Breeder II | Super Nintendo Entertainment System | 1994 | — |
| Thoroughbred Breeder III | Super Nintendo Entertainment System | 1996 | — |
| Thrillville: Off the Rails | Wii | 2007 | Frontier Developments |
| ThruSpace | Wii | 2010 | Keys Factory |
| Thunderbirds | Nintendo Entertainment System | 1989 | Pack-In-Video |
| Thundercade | Nintendo Entertainment System | 1987 | SETA Corporation |
| Tiger Woods PGA Tour 06 | Nintendo GameCube | 2005 | EA Sports |
| Tiger Woods PGA Tour 07 | Wii | 2006 | EA Sports |
| Tiger Woods PGA Tour 08 | Wii | 2007 | EA Orlando |
| Tiger Woods PGA Tour 09 | Wii | 2007 | EA Orlando |
| Tiger Woods PGA Tour 10 | Wii | 2009 | EA Orlando |
| Tiger Woods PGA Tour 11 | Wii | 2010 | EA Orlando |
| Tiger Woods PGA Tour 12 | Wii | 2011 | EA Orlando |
| Tiger Woods PGA Tour 2003 | Nintendo GameCube | 2002 | EA Sports |
| Tiger Woods PGA Tour 2004 | Nintendo GameCube | 2003 | EA Sports |
| Tiger Woods PGA Tour 2005 | Nintendo GameCube | 2004 | EA Sports |
| Tiger-Heli | Nintendo Entertainment System | 1985 | Bitwave Games, Toaplan, Micronics |