| Night at the Museum: Battle of the Smithsonian | Wii | 2009 | Amaze Entertainment |
| Nightmare Busters | Super Nintendo Entertainment System | 2013 | — |
| Nights: Journey of Dreams | Wii | 2007 | Sonic Team |
| Nightshade | Nintendo Entertainment System | 1992 | Krome Studios Melbourne |
| NightSky | Nintendo 3DS, Wii | 2013 | Nicalis |
| Niji no Silkroad | Nintendo Entertainment System | 1991 | NHK |
| Niki – Rock 'n' Ball | Wii | 2008 | Bplus |
| Nikoli's Pencil Puzzle | Nintendo 3DS | 2011 | — |
| Ninja Boy | Game Boy | 1990 | Culture Brain |
| Ninja Boy II | Game Boy | 1991 | Culture Brain |
| Ninja Crusaders | Nintendo Entertainment System | 1990 | NMK |
| Ninja Gaiden | Nintendo Entertainment System, Super Nintendo Entertainment System | 1988 | Tecmo |
| Ninja Gaiden II: The Dark Sword of Chaos | Nintendo Entertainment System | 1990 | Tecmo |
| Ninja Gaiden III: The Ancient Ship of Doom | Nintendo Entertainment System | 1991 | Tecmo |
| Ninja Gaiden Shadow | Game Boy | 1991 | Tecmo |
| Ninja Gaiden Trilogy | Super Nintendo Entertainment System | 1995 | Team Ninja |
| Ninja Hattori-kun | Nintendo Entertainment System | 1986 | Hudson Soft |
| Ninja JaJaMaru-kun | Nintendo Entertainment System | 1985 | Tose Co. |
| Ninja Kid | Nintendo Entertainment System | 1986 | Tose Co. |
| Ninja Kid | Super Nintendo Entertainment System | 1993 | Bandai |
| Ninja Reflex | Wii | 2008 | Sanzaru Games |
| Ninja Taro | Game Boy | 1991 | — |
| Ninja Twins | Game Boy | 2023 | — |
| Ninja-Kid | Nintendo Entertainment System | 1984 | Universal Entertainment, UPL |
| Ninjabread Man | Wii | 2005 | Data Design Interactive |
| Ninku | Game Boy | 1995 | — |
| Nintendo 3DS Guide: Louvre | Nintendo 3DS | 2012 | indieszero |
| Nintendo Badge Arcade | Nintendo 3DS | 2014 | Nintendo |
| Nintendo Campus Challenge 1991 | Nintendo Entertainment System | 1991 | Nintendo |
| Nintendo Campus Challenge 1992 | Nintendo Entertainment System | 1992 | Nintendo |
| Nintendo PowerFest '94 | Super Nintendo Entertainment System | 1994 | — |
| Nintendo Puzzle Collection | Nintendo GameCube | 2003 | Nintendo Research & Development 1 |
| Nintendo World Cup | Nintendo Entertainment System, Game Boy | 1990 | Technōs Japan |
| Nintendogs + Cats | Nintendo 3DS | 2011 | Nintendo Entertainment Analysis & Development |
| Nitrobike | Wii | 2008 | Left Field Productions |
| No Escape | Super Nintendo Entertainment System | 1994 | Bits Studios |
| No More Heroes | Wii | 2007 | Grasshopper Manufacture |
| No More Heroes 2: Desperate Struggle | Wii | 2010 | Grasshopper Manufacture |
| Noah's Ark | Nintendo Entertainment System | 1992 | Source Research & Development |
| Nobunaga's Ambition | Nintendo Entertainment System, Super Nintendo Entertainment System | 1986 | Koei Tecmo Games |
| Nobunaga's Ambition: Haouden | Super Nintendo Entertainment System | 1992 | Koei |
| Nobunaga's Ambition: Lord of Darkness | Super Nintendo Entertainment System | 1995 | — |
| Nodame Cantabile: Dream Orchestra | Wii | 2007 | Bandai Namco Entertainment |
| NOeSIS | Nintendo 3DS | 2011 | — |
| Nolan Ryan's Baseball | Super Nintendo Entertainment System | 1991 | Affect |
| Nontan to Issho: KuruKuru Puzzle | Super Nintendo Entertainment System, Game Boy | 1994 | Game Freak |
| North & South | Nintendo Entertainment System | 1989 | Infogrames |
| North American Hunting Extravaganza | Wii | 2008 | Arcade Moon |
| North American Hunting Extravaganza 2 | Wii | 2010 | Destineer |
| Nosferatu | Super Nintendo Entertainment System | 1994 | SETA Corporation |
| Now I Know My ABCs 2 | Nintendo 3DS | 2016 | Skunk Software |
| NPPL Championship Paintball 2009 | Wii | 2008 | Modus Studios Bucharest |
| Numan Athletics | Wii | 1993 | Namco |
| Nurikabe by Nikoli | Nintendo 3DS | 2012 | — |
| Nuts & Milk | Nintendo Entertainment System | 1984 | Hudson Soft |
| Nyoki Nyoki: Tabidachi Hen | Nintendo 3DS | 2016 | Compile Maru |
| NyxQuest: Kindred Spirits | Wii | 2009 | Over the Top Games |
| O-Chan no Oekaki Logic | Super Nintendo Entertainment System | 1995 | — |
| Obitus | Super Nintendo Entertainment System | 1991 | — |
| ObsCure II | Wii | 2007 | Mighty Rocket Studio |