| Neko Tomo | Nintendo 3DS | — | Groove Box Japan |
| Nemesis | Game Boy | 1990 | Konami |
| Neopets Puzzle Adventure | Wii | 2008 | Griptonite Games |
| Nerf N-Strike | Wii | 2008 | EA Salt Lake |
| Nerf N-Strike Elite | Wii | 2009 | EA Salt Lake |
| NES Open Tournament Golf | Nintendo Entertainment System | 1991 | Nintendo Research & Development 2 |
| NES Play Action Football | Nintendo Entertainment System | 1990 | Tose Co. |
| NEScape! | Nintendo Entertainment System | 2019 | — |
| Neves | Wii | 2007 | Yuke's |
| New 3D Golf Simulation: Harukanaru Augusta | Super Nintendo Entertainment System | 1991 | D Wonderland Inc. |
| New Carnival Games | Wii | 2010 | Cat Daddy Games |
| New Ghostbusters II | Nintendo Entertainment System, Game Boy | 1990 | HAL Laboratory |
| New LovePlus | Nintendo 3DS | 2012 | — |
| New LovePlus+ | Nintendo 3DS | 2014 | — |
| New Super Mario Bros. 2 | Nintendo 3DS | 2012 | Nintendo Entertainment Analysis & Development |
| New Super Mario Bros. Wii | Wii | 2009 | Nintendo Entertainment Analysis & Development |
| New Yatterman: Nandai Kandai Yajirobee | Super Nintendo Entertainment System | 1996 | — |
| Newman/Haas IndyCar featuring Nigel Mansell | Super Nintendo Entertainment System | 1994 | Gremlin Interactive |
| NewU Fitness First Mind Body, Yoga & Pilates Workout | Wii | 2010 | Lightning Fish |
| NewU Fitness First: Personal Trainer | Wii | 2009 | Lightning Fish |
| NFL | Nintendo Entertainment System | 1989 | Atlus |
| NFL Blitz 20-02 | Nintendo GameCube | 2001 | — |
| NFL Football | Game Boy | 1990 | — |
| NFL Football | Super Nintendo Entertainment System | 1993 | — |
| NFL QB Club 2002 | Nintendo GameCube | 2001 | Acclaim Games |
| NFL Quarterback Club | Super Nintendo Entertainment System, Game Boy | 1994 | Acclaim Studios Austin |
| NFL Quarterback Club 96 | Super Nintendo Entertainment System | 1995 | Acclaim Studios Austin |
| NFL Street | Nintendo GameCube | 2004 | EA Orlando |
| NFL Street 2 | Nintendo GameCube | 2004 | EA Sports Big |
| NHK Kōhaku Quiz Gassen | Wii | 2009 | Nintendo Entertainment Analysis & Development |
| NHL '94 | Super Nintendo Entertainment System | 1993 | EA Vancouver |
| NHL 06 | Nintendo GameCube | 2005 | EA Vancouver |
| NHL 2003 | Nintendo GameCube | 2002 | EA Sports |
| NHL 2004 | Nintendo GameCube | 2003 | EA Jawbreaker |
| NHL 2005 | Nintendo GameCube | 2004 | EA Jawbreaker |
| NHL 2K10 | Wii | 2009 | Visual Concepts |
| NHL 2K11 | Wii | 2010 | Visual Concepts |
| NHL 2K3 | Nintendo GameCube | 2002 | Treyarch |
| NHL 2K9 | Wii | 2008 | Visual Concepts |
| NHL 95 | Super Nintendo Entertainment System | 1994 | Visual Concepts |
| NHL 96 | Super Nintendo Entertainment System | 1995 | EA Orlando |
| NHL 97 | Super Nintendo Entertainment System | 1996 | — |
| NHL 98 | Super Nintendo Entertainment System | 1997 | EA Vancouver |
| NHL Hitz 2002 | Nintendo GameCube | 2001 | EA Jawbreaker |
| NHL Hitz 2003 | Nintendo GameCube | 2002 | EA Jawbreaker |
| NHL Hitz Pro | Nintendo GameCube | 2003 | Next Level Games |
| NHL Slapshot | Wii | 2010 | EA Vancouver |
| NHL Stanley Cup | Super Nintendo Entertainment System | 1993 | Sculptured Software |
| NHLPA Hockey '93 | Super Nintendo Entertainment System | 1992 | Park Place Productions |
| Nice de Shot | Super Nintendo Entertainment System | 1994 | Magical Company |
| Nichibutsu Arcade Classics | Super Nintendo Entertainment System | 1995 | — |
| Nickelodeon Dance | Wii | 2011 | High Voltage Software |
| Nickelodeon Dance 2 | Wii | 2012 | High Voltage Software |
| Nickelodeon Fit | Wii | 2010 | High Voltage Software |
| Nickelodeon Party Blast | Nintendo GameCube | 2002 | Data Design Interactive |
| Nicktoons MLB | Wii | 2011 | High Voltage Software |
| Nicktoons Unite! | Nintendo GameCube | 2005 | Blue Tongue Entertainment |
| Nicktoons: Attack of the Toybots | Wii | 2007 | Blue Tongue Entertainment |
| Nicktoons: Battle for Volcano Island | Nintendo GameCube | 2006 | Blue Tongue Entertainment |
| Nigel Mansell's World Championship Racing | Nintendo Entertainment System, Super Nintendo Entertainment System, Game Boy | 1993 | Gremlin Interactive |