| Indiana Jones and the Staff of Kings | Wii | 2009 | Behaviour Interactive |
| Indiana Jones and the Temple of Doom | Nintendo Entertainment System | 1988 | Atari Games |
| Indiana Jones' Greatest Adventures | Super Nintendo Entertainment System | 1994 | Lucasfilm Games, Factor 5 |
| Indianapolis 500 Legends | Wii | 2007 | Torus Games |
| Infiltrator | Nintendo Entertainment System, Apple II series | 1985 | Aackosoft, Gray Matter Inc. |
| Inindo: Way of the Ninja | Super Nintendo Entertainment System | 1991 | Koei |
| Initial D: Perfect Shift Online | Nintendo 3DS | 2014 | — |
| Inkub | Wii | 2010 | Cosmonaut Games |
| Inmost | Nintendo 3DS | 2020 | — |
| Insect Planet TD | Nintendo 3DS | 2018 | RandomSpin Games |
| Insector X | Nintendo Entertainment System | 1988 | Taito |
| Inspector Gadget | Super Nintendo Entertainment System | 1993 | Fortyfive |
| Intellivision Lives! | Nintendo GameCube | 1998 | Realtime Associates |
| International Cricket | Nintendo Entertainment System | 1992 | Krome Studios Melbourne |
| International Sensible Soccer | Super Nintendo Entertainment System | 1993 | — |
| International Superstar Soccer | Super Nintendo Entertainment System | 1994 | Konami |
| International Superstar Soccer | Game Boy | 1998 | — |
| International Superstar Soccer 2 | Nintendo GameCube | 2002 | Konami |
| International Superstar Soccer 3 | Nintendo GameCube | 2003 | Konami |
| International Superstar Soccer Deluxe | Super Nintendo Entertainment System | 1995 | Konami |
| International Tennis Tour | Super Nintendo Entertainment System | 1993 | — |
| Intervilles | Wii | 2007 | Belle Productions |
| Ippatsu Gyakuten: Keiba Keirin Kyōtei | Super Nintendo Entertainment System | 1996 | — |
| Iron Chef America: Supreme Cuisine | Wii | 2008 | Black Lantern Studios, Inc. |
| Iron Combat: War in the Air | Nintendo 3DS | 2013 | Amzy |
| Iron Commando | Super Nintendo Entertainment System | 1995 | Arcade Zone |
| Iron Man | Wii | 2008 | Sega Studios San Francisco |
| Iron Man 2 | Wii | 2010 | Sega Studios San Francisco |
| Iron Tank | Nintendo Entertainment System | 1988 | SNK, SNK |
| IronFall: Invasion | Nintendo 3DS | 2015 | — |
| Ironsword: Wizards & Warriors II | Nintendo Entertainment System | 1989 | Rare Ltd. |
| Island Days | Nintendo 3DS | 2014 | Overflow, Klon |
| Isolated Warrior | Nintendo Entertainment System | 1991 | KID |
| Isozuri: Ritou Hen | Super Nintendo Entertainment System | 1996 | — |
| Itadaki Street 2: Neon Sign wa Bara Iro ni | Super Nintendo Entertainment System | 1994 | ASCII Corporation |
| Itadaki Street: Watashi no Omise ni Yottette | Nintendo Entertainment System | 1991 | Game Studio |
| Itoi Shigesato no Bass Tsuri No. 1 | Super Nintendo Entertainment System | 1997 | HAL Laboratory |
| Ivan 'Ironman' Stewart's Super Off Road | Nintendo Entertainment System, Super Nintendo Entertainment System | 1989 | Leland Corporation |
| Ivy the Kiwi? | Wii | 2009 | Prope |
| J-League Fighting Soccer | Nintendo Entertainment System, Game Boy | 1992 | International Games System |
| J-League Winning Goal | Nintendo Entertainment System, Game Boy | 1994 | Graphic Research Co., Ltd. |
| J. League Super Top Players | Nintendo Entertainment System | 1994 | Tose Co. |
| J.League Excite Stage | Super Nintendo Entertainment System | 1994 | — |
| J.League Soccer Prime Goal | Super Nintendo Entertainment System | 1993 | — |
| J.League Super Soccer '95 Jikkyō Stadium | Super Nintendo Entertainment System | 1995 | — |
| J.R.R. Tolkien's The Lord of the Rings, Vol. I | Super Nintendo Entertainment System | 1994 | Interplay Entertainment |
| Jack Nicklaus' Greatest 18 Holes of Major Championship Golf | Nintendo Entertainment System | 1988 | Sculptured Software |
| Jackal | Nintendo Entertainment System | 1988 | Konami |
| Jacked | Nintendo GameCube | 2006 | Sproing Interactive Media |
| Jackie Chan's Action Kung Fu | Nintendo Entertainment System | 1990 | Now Production |
| JaJaMaru Gekimaden: Maboroshi no Kinmajou | Nintendo Entertainment System | 1990 | Jaleco |
| JaJaMaru no Daibouken | Nintendo Entertainment System | 1986 | Jaleco |
| JaJaMaru: Ninpō Chō | Nintendo Entertainment System | 1989 | NMK |
| Jake Hunter Detective Story: Ghost of the Dusk | Nintendo 3DS | 2017 | Arc System Works |
| Jaki Crush | Super Nintendo Entertainment System | 1992 | Kaga Create |
| Jambo! Safari | Wii | 2009 | Sega AM2 |
| Jambo! Safari: Animal Rescue | Wii | 2009 | Full Fat |
| James Bond 007 | Game Boy | 1998 | Saffire |
| James Bond 007: Agent Under Fire | Nintendo GameCube | 2001 | Visceral Games, Electronic Arts |
| James Bond 007: Everything or Nothing | Nintendo GameCube | 2004 | Visceral Games |