| Hydro Thunder | Nintendo GameCube | 1999 | Midway Games |
| Hyper Fighters | Wii | 2011 | Team6 Game Studios |
| Hyper Iria | Super Nintendo Entertainment System | 1995 | TamTam Co., Ltd. |
| Hyper Lode Runner | Game Boy | 1989 | Bandai |
| Hyper Sports | Nintendo Entertainment System | 1984 | Konami |
| Hyper Zone | Super Nintendo Entertainment System | 1991 | HAL Laboratory |
| Hyrule Warriors Legends | Nintendo 3DS | 2016 | Team Ninja, Omega Force |
| Hysteria Hospital: Emergency Ward | Wii | 2009 | GameInvest |
| I Love Softball | Nintendo Entertainment System | 1989 | Marionette Co., Ltd. |
| I Spy Spooky Mansion | Wii | 1999 | Scholastic Corporation |
| I-Ninja | Nintendo GameCube | 2003 | Argonaut Games |
| I.F.O | Nintendo 3DS | 2017 | — |
| ICarly | Wii | 2009 | Blitz Games |
| ICarly 2: iJoin the Click! | Wii | 2010 | Big Blue Bubble |
| Ice Age 2: The Meltdown | Nintendo GameCube, Wii | 2006 | Eurocom |
| Ice Age: Continental Drift – Arctic Games | Nintendo 3DS, Wii | 2012 | Behaviour Interactive |
| Ice Age: Dawn of the Dinosaurs | Wii | 2009 | Eurocom |
| Ice Climber | Nintendo Entertainment System | 1985 | Nintendo Research & Development 1 |
| Ice Cream Surfer | PlayStation Vita, Nintendo 3DS | 2014 | Dolores Entertainment |
| Ice Hockey | Nintendo Entertainment System | 1988 | Nintendo Entertainment Analysis & Development, Nintendo Research & Development 2 |
| Ice Station Z | Nintendo 3DS | 2016 | Wobbly Tooth |
| Idea no Hi | Super Nintendo Entertainment System | 1994 | Office Koukan |
| Idol Hakkenden | Nintendo Entertainment System | 1989 | Winning Entertainment Group |
| Idol Janshi Suchie-Pai | Super Nintendo Entertainment System | 1993 | — |
| Igor: The Game | Wii | 2008 | Santa Cruz Games |
| Ihatovo Monogatari | Super Nintendo Entertainment System | 1993 | Hect |
| Ikari III: The Rescue | Nintendo Entertainment System | 1989 | SNK, SNK |
| Ikari Warriors | Nintendo Entertainment System | 1986 | SNK |
| Ikaruga | Nintendo GameCube | 2001 | Treasure |
| Ikenie no Yoru | Wii | 2011 | Marvelous Entertainment |
| Ikinari Musician | Nintendo Entertainment System | 1987 | Tokyo Shoseki |
| Ikki | Nintendo Entertainment System | 1985 | Tose Co. |
| Illuminated | Game Boy | 2023 | — |
| Illusion of Gaia | Super Nintendo Entertainment System | 1993 | Quintet |
| Illvelo | Wii | 2008 | Milestone |
| Imabikisō | Wii | 2007 | Chunsoft |
| Image Fight | Nintendo Entertainment System | 1990 | Irem |
| Imagine Babies 3D | Nintendo 3DS | 2012 | — |
| Imagine Babyz | Nintendo 3DS | 2007 | Ubisoft |
| Imagine Champion Rider 3D | Nintendo 3DS | 2013 | Neko Entertainment |
| Imagine Fashion Party | Wii | 2009 | Lexis Numérique |
| Imagine Fashion World 3D | Nintendo 3DS | 2012 | — |
| Imagine: Champion Rider | Wii | 2008 | Phoenix Studio |
| Imagine: Fashion Designer 3D | Nintendo 3DS | 2007 | — |
| Imperium | Super Nintendo Entertainment System | 1992 | Tokai Communications |
| Impossible Mission | Wii | 2007 | System 3 |
| Impossible Mission II | Nintendo Entertainment System | 1988 | Appaloosa Interactive |
| Inazuma Eleven | Nintendo 3DS | 2008 | Level-5 |
| Inazuma Eleven 1-2-3!! Endō Mamoru densetsu | Nintendo 3DS | 2012 | Level-5 |
| Inazuma Eleven 3 | Nintendo 3DS | 2010 | Level-5 |
| Inazuma Eleven GO | Nintendo 3DS | 2011 | Level-5 |
| Inazuma Eleven GO 2: Chrono Stone | Nintendo 3DS | 2012 | Level-5 |
| Inazuma Eleven GO 3: Galaxy | Nintendo 3DS | 2013 | Level-5 |
| Inazuma Eleven GO Strikers 2013 | Wii | 2012 | Level-5 |
| Inazuma Eleven Strikers | Wii | 2011 | Level-5 |
| Inazuma Eleven Strikers 2012 Xtreme | Wii | 2011 | Level-5 |
| Incantation | Super Nintendo Entertainment System | 1996 | Titus Interactive |
| Incoming! | Wii | 2009 | JV Games |
| Indiana Jones and the Last Crusade | Nintendo Entertainment System | 1991 | Taito |
| Indiana Jones and the Last Crusade: The Action Game | Nintendo Entertainment System | 1989 | Tiertex Design Studios |