| Flying Hero | Nintendo Entertainment System | 1989 | Aicom |
| Flying Hero | Super Nintendo Entertainment System | 1992 | Sting |
| Flying Shark | Nintendo Entertainment System | 1987 | Bitwave Games, Toaplan, Software Creations |
| Flying Warriors | Nintendo Entertainment System | 1991 | Culture Brain |
| Food Network: Cook or Be Cooked | Wii | 2009 | Red Fly Studio |
| Football Champ | Super Nintendo Entertainment System | 1990 | Taito |
| Football Fury | Super Nintendo Entertainment System | 1992 | — |
| Foreman For Real | Super Nintendo Entertainment System, Game Boy | 1995 | Software Creations |
| Formation Z | Nintendo Entertainment System | 1984 | Jaleco |
| Formula One: Built to Win | Nintendo Entertainment System | 1990 | Winkysoft |
| Fort Boyard: The Game | Wii | 2006 | Dream On Studio, Mindscape, Mad Monkey Studio |
| Fortified Zone | Game Boy | 1991 | Jaleco |
| Fortune Street | Wii | 2011 | Marvelous |
| Fossil Fighters: Frontier | Nintendo 3DS | 2015 | Spike Chunsoft |
| Fractured Soul | Nintendo 3DS | 2012 | Endgame Studios |
| Fragile Dreams: Farewell Ruins of the Moon | Wii | 2009 | Namco |
| Frank Thomas' Big Hurt Baseball | Super Nintendo Entertainment System | 1995 | Acclaim Studios Austin |
| Frankenstein: The Monster Returns | Nintendo Entertainment System | 1991 | Tose Co. |
| Franklin: A Birthday Surprise | Nintendo GameCube | 2006 | — |
| Frantic Flea | Super Nintendo Entertainment System | 1996 | — |
| Freaky Flyers | Nintendo GameCube | 2003 | Midway Games |
| Freakyforms: Your Creations, Alive! | Nintendo 3DS | 2011 | — |
| Free Running | Wii | 2007 | Rebellion Developments |
| Freedom Fighters | Nintendo GameCube | 2003 | IO Interactive |
| Freedom Force | Nintendo Entertainment System | 1988 | Sunsoft |
| Freekstyle | Nintendo GameCube | 2002 | Page 44 Studios |
| Freestyle MetalX | Nintendo GameCube | 2003 | — |
| Freestyle Street Soccer | Nintendo GameCube | 2004 | Silicon Dreams |
| Friday the 13th | Nintendo Entertainment System | 1989 | Pack-In-Video |
| Fritz Chess | Wii | 2009 | Freedom Factory Studios |
| Frobot | Wii | 2010 | Fugazo |
| Frog Feast | Super Nintendo Entertainment System | 2005 | — |
| Frogger | Super Nintendo Entertainment System, Game Boy | 1981 | Konami |
| Frogger 3D | Nintendo 3DS | 2011 | — |
| Frogger Beyond | Nintendo GameCube | 2002 | Konami |
| Frogger's Adventures: The Rescue | Nintendo GameCube | 2003 | Konami |
| Frogger: Ancient Shadow | Nintendo GameCube | 2005 | Hudson Soft |
| Frogger: Hyper Arcade Edition | Wii | 2012 | Zombie Studios |
| FROM BELOW - A Real NES Game! | Nintendo Entertainment System | 2020 | — |
| From Russia with Love | Nintendo GameCube | 2005 | Visceral Games |
| From TV animation - Slam Dunk SD Heat Up!! | Super Nintendo Entertainment System | 1995 | — |
| Front Line | Nintendo Entertainment System | 1982 | Taito |
| Front Mission | Super Nintendo Entertainment System | 1995 | G-Craft |
| Front Mission Series: Gun Hazard | Super Nintendo Entertainment System | 1996 | — |
| Frozen: Olaf's Quest | Nintendo 3DS | 2013 | 1st Playable Productions |
| Fujiko F. Fujio Characters: Daishuugou! SF Dotabata Party!! | Nintendo 3DS | 2014 | — |
| Full Pipe | Nintendo GameCube | 2003 | — |
| Full Throttle: All-American Racing | Super Nintendo Entertainment System | 1994 | Gremlin Interactive |
| Fullmetal Alchemist: Akatsuki No Ouji | Wii | 2009 | Square Enix |
| Fullmetal Alchemist: Tasogare no Shoujo | Wii | 2009 | Square Enix |
| Fun 'n Games | Super Nintendo Entertainment System | 1993 | Leland Interactive Media |
| Fun House | Nintendo Entertainment System | 1991 | Realtime Associates |
| Fun! Fun! Minigolf | Wii | 2008 | Shin'en Multimedia |
| Funaki Masakatsu: Hybrid Wrestler | Super Nintendo Entertainment System | 1994 | — |
| Funky Barn | Nintendo 3DS | 2012 | Tantalus Media |
| Furu Furu Park | Wii | 2007 | Taito |
| Furuta Atsuya no Simulation Pro Yakyuu 2 | Super Nintendo Entertainment System | 1996 | Hect |
| Future Basketball | Super Nintendo Entertainment System | 1991 | Hudson Soft |
| Future GPX Cyber Formula | Game Boy | 1992 | — |
| Future Tactics: The Uprising | Nintendo GameCube | 2004 | — |