| Super Strike Eagle | Super Nintendo Entertainment System | 1993 | MicroProse |
| Super Swing Golf | Wii | 2006 | Ntreev Soft |
| Super Swing Golf: Season 2 | Wii | 2007 | Tecmo |
| Super SWIV | Super Nintendo Entertainment System | 1992 | Eidos Interactive |
| Super Team Games | Nintendo Entertainment System | 1986 | Human Entertainment |
| Super Tennis | Super Nintendo Entertainment System | 1991 | Tokyo Shoseki |
| Super Tetris 3 | Super Nintendo Entertainment System | 1994 | — |
| Super Tilt Bro. | Nintendo Entertainment System | 2024 | — |
| Super Troll Islands | Super Nintendo Entertainment System | 1994 | — |
| Super Turrican | Nintendo Entertainment System | 1992 | Rainbow Arts |
| Super Turrican | Super Nintendo Entertainment System | 1993 | Factor 5 |
| Super Turrican 2 | Super Nintendo Entertainment System | 1995 | Factor 5 |
| Super Ultra Baseball 2 | Super Nintendo Entertainment System | 1994 | Culture Brain |
| Super Valis IV | Super Nintendo Entertainment System | 1992 | — |
| Super Wagan Land | Super Nintendo Entertainment System | 1991 | — |
| Super Widget | Super Nintendo Entertainment System | 1993 | — |
| Super Wrestle Angels | Super Nintendo Entertainment System | 1994 | — |
| Super Xevious: GAMP no Nazo | Nintendo Entertainment System | 1986 | Tose Co. |
| Super Ōzumō: Netsusen Daiichiban | Super Nintendo Entertainment System | 1992 | Namco |
| Superman | Nintendo Entertainment System | 1987 | Kemco |
| Superman: Shadow of Apokolips | Nintendo GameCube | 2002 | Gremlin Interactive |
| Supremacy: Your Will Be Done | Nintendo Entertainment System | 1990 | Acclaim Studios London |
| Surf's Up | Nintendo GameCube, Wii | 2007 | Ubisoft Montreal |
| Survival Kids | Game Boy | 1999 | Konami |
| Sutobasu Yarō Shō | Super Nintendo Entertainment System | 1994 | KID |
| Sutte Hakkun | Super Nintendo Entertainment System | 1997 | Nintendo Research & Development 2 |
| Suzuka 8 Hours | Super Nintendo Entertainment System | 1992 | Arc System Works |
| Swamp Thing | Nintendo Entertainment System, Game Boy | 1992 | Imagineering |
| SWAT Kats: The Radical Squadron | Super Nintendo Entertainment System | 1995 | Fortyfive |
| Swingerz Golf | Nintendo GameCube | 2002 | Telenet Japan |
| SWIV | Super Nintendo Entertainment System | 1991 | — |
| Sword Master | Nintendo Entertainment System | 1990 | Athena |
| Sword World SFC | Super Nintendo Entertainment System | 1993 | — |
| Swords & Soldiers | Nintendo 3DS, Wii | 2009 | Ronimo Games |
| Swords and Serpents | Nintendo Entertainment System | 1990 | Interplay Entertainment |
| SX Superstar | Nintendo GameCube | 2003 | Climax Studios |
| Syndicate | Super Nintendo Entertainment System | 1993 | Bullfrog Productions |
| Syvalion | Super Nintendo Entertainment System | 1988 | Taito |
| Taboo: The Sixth Sense | Nintendo Entertainment System | 1989 | Rare Ltd. |
| Tactical Soccer | Super Nintendo Entertainment System | 1995 | — |
| Tactics Ogre: Let Us Cling Together | Super Nintendo Entertainment System | 1995 | Quest |
| Tadaima Yuusha Boshuuchuu Okawari | Super Nintendo Entertainment System | 1994 | Human Entertainment |
| Taekwon-Do | Super Nintendo Entertainment System | 1994 | — |
| Tag Team Match: MUSCLE | Nintendo Entertainment System | 1985 | Tose Co. |
| Tag Team Wrestling | Nintendo Entertainment System | 1983 | Technōs Japan |
| Taiko no Tatsujin Wii | Wii | 2008 | Namco |
| Taiko no Tatsujin Wii: Do Don to Nidaime | Wii | 2009 | Namco |
| Taiko no Tatsujin Wii: Kettei-Ban | Wii | 2011 | Namco |
| Taiko no Tatsujin Wii: Minna de Party Sandaime | Wii | 2010 | Namco |
| Taiko no Tatsujin: Don to Katsu no Jikū Daibōken | Nintendo 3DS | 2014 | Namco |
| Taiko Risshiden | Super Nintendo Entertainment System | 1992 | Koei |
| Tail 'Gator | Game Boy | 1992 | Winning Entertainment Group |
| Tails Adventure | Nintendo 3DS | 1995 | Aspect |
| Taito Grand Prix: Eikou heno License | Nintendo Entertainment System | 1987 | Now Production |
| Tak 2: The Staff of Dreams | Nintendo GameCube | 2004 | Avalanche Software |
| Tak and the Guardians of Gross | Wii | 2008 | Blitz Games |
| Tak and the Power of Juju | Nintendo GameCube | 2003 | Avalanche Software |
| Tak: The Great Juju Challenge | Nintendo GameCube | 2005 | Avalanche Software |
| Takahashi Meijin no Bug-tte Honey | Nintendo Entertainment System | 1987 | Hudson Soft |
| Take Yutaka G1 Memory | Super Nintendo Entertainment System | 1995 | Gaps |