| Mega Man IV | 1993 | Capcom |
| Mega Man V | 1994 | Capcom |
| Mega Man: Dr. Wily's Revenge | 1991 | Capcom |
| Megalit | 1991 | ASCII Corporation |
| Megami Tensei Gaiden: Last Bible II | 1993 | — |
| Meitantei Conan - Chika yūenchi satsujin jiken | 1996 | — |
| Mercenary Force | 1990 | — |
| Metal Masters | 1993 | Bit Managers |
| Metroid II: Return of Samus | 1991 | Nintendo Research & Development 1 |
| Mickey Mouse: Magic Wands! | 1993 | Kemco |
| Mickey's Dangerous Chase | 1991 | Now Production |
| Micro Machines | 1991 | Codemasters |
| Micro Machines 2: Turbo Tournament | 1994 | Codemasters |
| MIDI Maze | 1987 | — |
| Mighty Morphin Power Rangers: The Movie | 1995 | Winning Entertainment Group |
| Mikeneko Homuzu no Kishido | 1991 | — |
| Milon's Secret Castle | 1986 | Hudson Soft |
| Miner 2049er | 1982 | Big Five Software |
| Missile Command | 1980 | Atari, Inc. |
| Mole Mania | 1996 | Nintendo Entertainment Analysis & Development |
| Monster Max | 1994 | Rare Ltd. |
| Monster Truck | 1990 | — |
| Monster Truck Wars | 1994 | — |
| Mortal Kombat | 1992 | Midway Games |
| Mortal Kombat 3 | 1995 | Midway Games |
| Mortal Kombat II | 1993 | Midway Games |
| Mortal Kombat: Deadly Alliance | 2002 | Midway Games |
| Motocross Maniacs | 1989 | Konami |
| Mouse Trap Hotel | 1992 | Imagineering |
| Mr. Chin's Gourmet Paradise | 1990 | Romstar |
| Mr. Do! | 1995 | Universal Entertainment |
| Ms. Pac-Man | 1982 | Midway Games |
| Mysterium | — | Maxis |
| Mystery Dungeon: Shiren the Wanderer | 1995 | Chunsoft |
| Mystical Ninja Starring Goemon | 1997 | Konami |
| Nail 'n' Scale | 1990 | Data East |
| NBA Live 96 | 1995 | EA Sports |
| Nemesis | 1990 | Konami |
| New Ghostbusters II | 1990 | HAL Laboratory |
| NFL Football | 1990 | — |
| NFL Quarterback Club | 1994 | Acclaim Studios Austin |
| Nigel Mansell's World Championship Racing | 1993 | Gremlin Interactive |
| Ninja Boy | 1990 | Culture Brain |
| Ninja Boy II | 1991 | Culture Brain |
| Ninja Gaiden Shadow | 1991 | Tecmo |
| Ninja Taro | 1991 | — |
| Ninja Twins | 2023 | — |
| Ninku | 1995 | — |
| Nintendo World Cup | 1990 | Technōs Japan |
| Nontan to Issho: KuruKuru Puzzle | 1994 | Game Freak |
| Oddworld: Abe's Oddysee | 1997 | Oddworld Inhabitants |
| Olympic Summer Games | 1996 | Silicon Dreams Studios, Tiertex Design Studios |
| Operation C | 1991 | Konami |
| Out of Gas | 1992 | Realtime Associates |
| Pac-In-Time | 1994 | Kalisto Entertainment |
| Painter Momopii | 1990 | — |
| Palamedes | 1990 | Taito |
| Panel Action Bingo | 1993 | — |
| Pang | 1989 | Capcom |
| Paperboy | 1985 | Atari Games |