| Side Pocket | 1986 | Data East |
| Skate or Die: Bad 'N Rad | — | Konami |
| Skate or Die: Tour de Thrash | 1991 | Electronic Arts |
| Slam Dunk | 1994 | Tose Co. |
| Slam Dunk 2: IH Yosen Kanzenban!! | 1995 | — |
| Small Soldiers | 1998 | — |
| Sneaky Snakes | — | Rare Ltd. |
| Snoopy's Magic Show | 1990 | Kemco |
| Snow Bros.: Nick and Tom | 1990 | Toaplan |
| Soccer | 1991 | Tose Co. |
| Soccer Mania | 1990 | — |
| Solar Striker | 1990 | Nintendo Research & Development 1 |
| Soldam | 1992 | Jaleco |
| Solomon's Club | 1991 | — |
| Space Invaders | 1978 | Taito |
| Spanky's Quest | 1991 | Winning Entertainment Group |
| Speedball | 1988 | The Bitmap Brothers |
| Speedy Gonzales | 1993 | — |
| Speedy Gonzales: Aztec Adventure | 1999 | Sunsoft |
| Spider-Man 3: Invasion of the Spider-Slayers | 1993 | Bits Studios |
| Spider-Man and the X-Men in Arcade's Revenge | 1993 | Software Creations |
| Sports Collection | 1996 | Tose Co. |
| Spot: The Cool Adventure | 1994 | Visual Concepts |
| Spot: The Video Game | 1990 | Visual Concepts, Virgin Interactive |
| Spud's Adventure | 1991 | Atlus |
| Spy vs. Spy | 1984 | Aackosoft, First Star Software |
| Square Deal: The Game of Two Dimensional Poker | 1990 | Human Engineered Software, Hect |
| Star Trek Prodigy: Supernova | 2022 | Tessera Studios |
| Star Trek: 25th Anniversary | 1992 | Visual Concepts |
| Star Trek: Tactical Assault | 2006 | Quicksilver Software |
| Star Trek: The Next Generation | 1993 | Absolute Entertainment |
| Star Wars | 1991 | Lucasfilm Games, Krome Studios Melbourne, NMS Software, Tiertex Design Studios |
| Star Wars: The Empire Strikes Back | 1992 | Lucasfilm Games, Sculptured Software |
| Stargate | 1994 | — |
| Starsweep | 1997 | — |
| Stop That Roach! | 1994 | — |
| Storm Chaser: Tornado Alley | 2018 | Skunk Software |
| Street Fighter II | 1991 | Capcom |
| Street Racer | 1994 | — |
| Sumo Fighter: Tōkaidō Basho | 1991 | KID |
| Sunsoft Grand Prix | 1990 | — |
| Super Bombliss | 1995 | — |
| Super Chinese Fighter GB | 1996 | Culture Brain |
| Super Chinese Land 1-2-3 Dash | 1995 | Culture Brain |
| Super Chinese Land 3 | 1995 | Culture Brain |
| Super Hunchback | 1992 | Ocean Software |
| Super JetPak DX | 2023 | — |
| Super Mario Land | 1989 | Nintendo Entertainment Analysis & Development |
| Super Mario Land 2: 6 Golden Coins | 1992 | Nintendo Research & Development 1 |
| Super R.C. Pro-Am | 1992 | Rare Ltd. |
| Super Robot Wars | 1991 | — |
| Super Star Wars: Return of the Jedi | 1994 | Realtime Associates, Sculptured Software |
| Survival Kids | 1999 | Konami |
| Swamp Thing | 1992 | Imagineering |
| Tail 'Gator | 1992 | Winning Entertainment Group |
| Takeda Nobuhiro no Ace Striker | 1994 | Tose Co. |
| Talespin | 1991 | Capcom |
| Tamagotchi | 1997 | — |
| Tarzan: Lord of the Jungle | 1994 | Eurocom |
| Taz-Mania | 1992 | NuFX |